Blood mitochondrial health markers cf-mtDNA and GDF15 in human aging

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Altered mitochondria biology can accelerate biological aging, but scalable biomarkers of mitochondrial health for population studies are lacking. We examined two potential candidates: 1) cell-free DNA (cf-mtDNA), a marker signaling elevated with disease states accessible as distinct entities from plasma or serum; and 2) growth differentiation factor 15 (GDF15), an established biomarker aging downstream energy transformation defects stress signaling. In cohort 430 participants aged 24-84 (54.2% women), we measured serum cf-mtDNA, GDF15 levels at timepoints 5 years apart, then assessed their associations age, BMI, diabetes, sex, health-related behaviors, psychosocial factors. As expected, showed positive, exponential association age (r=0.66, p<0.0001) increased by 33% over five years. cf-mtDNA was not correlated age. BMI sex were also related to nor GDF15. Type 2 diabetes only positively associated Exploring drivers systemic signaling, report novel linking higher education lower age-adjusted (r=-0.14, p<0.0034), both baseline the 5-year follow up, highlighting influence factors on health. Overall, our findings among adults spanning six decades lifespan establish between GDF15, emerging Further needed determine if blood metabolic be moderated behaviors.

Language: Английский

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A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(10), P. 884 - 901

Published: Oct. 1, 2024

Language: Английский

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Neurodegenerative disorders, metabolic icebergs, and mitohormesis

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 6, 2024

Language: Английский

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Mitochondrial respiratory activity and DNA damage in peripheral blood mononuclear cells in borderline personality disorder

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Alterations in the central and peripheral energy metabolism are increasingly recognized as key pathophysiological processes various psychiatric disorders. This case-control study investigates mitochondrial production oxidative DNA damage Borderline Personality Disorder (BPD). We compared respiration, density, blood mononuclear cells between women with acute BPD, remitted healthy controls ( n = 32, 15, 29), matched for age BMI. Acute BPD was characterized by reduced less efficient ATP to both (e.g., coupling efficiency: r x −0.36 −0.35, p adj ’s < .037). Decreased activity closely associated greater S −0.57, .001), although did not differ diagnostic groups. Our findings suggest promising sensitive biomarkers disorder severity clinical remission BPD.

Language: Английский

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A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Mitochondria are a diverse family of organelles that specialize to accomplish complimentary functions. All mitochondria share general features, but not all created equal.Here we develop quantitative pipeline define the degree molecular specialization among different mitochondrial phenotypes - or mitotypes. By distilling hundreds validated genes/proteins into 149 biologically interpretable MitoPathway scores (MitoCarta 3.0) simple mitotyping allows investigators quantify and interpret diversity plasticity from transcriptomics data across variety natural experimental contexts. We show mouse human multi-organ mitotypes segregate along two main axes specialization, contrasting anabolic (liver) catabolic (brain) tissues. In brain, cell-type-specific enrichment at single cell level. cultured primary fibroblasts exhibiting robust time-dependent treatment-induced metabolic plasticity, demonstrate how mitotype given type recalibrates i) over time in parallel with hallmarks aging, ii) response genetic, pharmacological, perturbations. Investigators can now use MitotypeExplorer.org associated code visualize, multivariate space biology.

Language: Английский

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Possible Anti-Aging and Anti-Stress Effects of Long-Term Transcendental Meditation Practice: Differences in Gene Expression, EEG Correlates of Cognitive Function, and Hair Steroids

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 317 - 317

Published: Feb. 20, 2025

Background: Our previous comparison of peripheral blood mononuclear cells (PBMCs) from long-term Transcendental Meditation® (TM®) practitioners and matched non-practitioner controls found 200 differentially expressed (DE) genes. Bioinformatics analyses these DE genes suggested a reduced risk diseases associated with stress aging in the TM group. Here we assessed additional signs aging. Methods: A sample 15 was studied using qPCR PBMCs 40-year (“Old TM”, n = 23) compared to “Young Control” group (n 19) an “Old 21) non-meditators. In three groups, plus 12-year practitioner 26), also EEG-based parameters cognitive function (the Brain Integration Scale (BIS), latency components event-related potential (ERP)). Finally, LC/MS/MS, persistent levels cortisol (F) its inactive congener, cortisone (E), hair. Results: analysis showed that 13 were more highly Old Controls than Young Controls. group, 7 lower Both groups had higher BIS scores their age-matched controls. The shorter N2, P3a, P3b latencies Control not longer Hair F/Hair E ratio control subgroups subgroups, F combined groups. Conclusions: These results are consistent reductions biomarkers chronic biological age meditators. They study suggesting practice lowers energy consumption or leads efficient metabolism.

Language: Английский

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From energy metabolism to mood regulation: The rise of lactate as a therapeutic target

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Disruption of cerebral energy metabolism is increasingly recognized as a key factor in the pathophysiology mood disorders. Lactate, beyond its role metabolic byproduct, now understood to be critical player brain homeostasis and modulator neuronal function. Recent advances understanding lactate shuttling between astrocytes neurons have opened new avenues for exploring multifaceted roles regulation. Exercise, known modulate levels, further underscores potential therapeutic target This review delves into alterations associated with disorders, emphasizing their implications dynamics signaling pathways. Additionally, we discuss particularly through capacity remodel We conclude by assessing promise exercise-induced production novel strategy disorder treatment. Alterations may contribute pathogenesis In several studies, not only substrate metabolism, but also molecule that triggers cascades. Specifically, involved regulation neurogenesis, neuroplasticity, endothelial cell function, microglia lysosomal acidification, therefore improving Meanwhile, exercise low-risk intervention can improve disorders Thus, evidence from this supports could disorder, contributing deeper intervention.

Language: Английский

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Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework

Psychiatry Research, Journal Year: 2024, Volume and Issue: 342, P. 116220 - 116220

Published: Oct. 2, 2024

Language: Английский

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Evaluation of mitochondrial activity via cellular interactions between adrenal and neuronal cells in a microfluidic coculture device

Biotechnology and Bioprocess Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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New insights into the relationship of mitochondrial metabolism and atherosclerosis

Cellular Signalling, Journal Year: 2024, Volume and Issue: 127, P. 111580 - 111580

Published: Dec. 27, 2024

Language: Английский

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