Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: molecular mechanisms and targeted therapies

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107588 - 107588

Published: Jan. 7, 2025

Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity involved in pathogenesis of atherosclerosis. With advance metabolomics epigenetics, metabolites/metabolic epigenetic modification such as DNA methylation, histone noncoding RNA, play crucial role polarization progression Herein, we provide comprehensive review essential metabolic regulation, well crosstalk between two regulating We also highlight potential therapeutic strategies via modifications for atherosclerosis, offer recommendations to our knowledge roles metabolic-epigenetic context Fundamental studies that elucidate mechanisms by which regulation influence atherosclerosis will pave way novel approaches.

Language: Английский

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Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity

Developmental Cell, Journal Year: 2024, Volume and Issue: 59(21), P. 2807 - 2817.e8

Published: Aug. 7, 2024

Language: Английский

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Immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors

Nature Cardiovascular Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Immune checkpoint inhibitor (ICI) therapies can increase the risk of cardiovascular events in survivors cancer by worsening atherosclerosis. Here we map expression immune checkpoints (ICs) within human carotid and coronary atherosclerotic plaques, revealing a network cell interactions that ICI treatments unintentionally target arteries. We identify population mature, regulatory CCR7+FSCN1+ dendritic cells, similar to those described tumors, as hub IC-mediated signaling plaques. Additionally, show type 2 diabetes lipid-lowering alter through PD-1, CTLA4, LAG3 other IC targets clinical development, impacting plaque inflammation. This comprehensive interactome healthy cardiometabolic disease states provides framework for understanding potential adverse beneficial impacts approved investigational ICIs on atherosclerosis, setting stage designing strategies minimize survivors. Barcia Durán, Dayasagar, et al. atherosclerosis examine influence understand how inhibitors worsen cancer.

Language: Английский

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Dissecting S-itaconation at host–pathogen interactions with chemical proteomics tools

Current Opinion in Microbiology, Journal Year: 2025, Volume and Issue: 83, P. 102579 - 102579

Published: Jan. 21, 2025

Language: Английский

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Preclinical insights into the potential of itaconate and its derivatives for liver disease therapy

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156152 - 156152

Published: Feb. 1, 2025

Language: Английский

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Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

To investigate the mechanisms behind worsening of acute lung injury (ALI) in obesity, transcriptomic sequencing is performed, and significantly reduced mRNA levels Aconitate Decarboxylase 1 (ACOD1) tissue high-fat diet (HFD) mice are found. Clinical samples collected, an ALI model established HFD mice, both human mouse analyzed, revealing a significant decrease ACOD1 expression alveolar macrophages obesity. Further vivo vitro experiments show that knockdown worsens injury, inflammation, oxidative stress, while overexpression alleviates these effects. Moreover, nuclear factor erythroid 2-related 2 (Nrf2) inhibition diminishes protective effects exacerbated by Additionally, context growth independent (GFI1) protein elevated macrophages, its leads to upregulated expression. Therefore, this study suggests downregulation key likely driven GFI1 upregulation.

Language: Английский

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Itaconate facilitates methane-induced Nrf2 pathway activation for mitigating liver ischemia and reperfusion injury

iLiver, Journal Year: 2025, Volume and Issue: unknown, P. 100144 - 100144

Published: Feb. 1, 2025

Language: Английский

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Insights into the itaconate family: immunomodulatory mechanisms and therapeutic potentials

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177542 - 177542

Published: March 1, 2025

Language: Английский

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Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Language: Английский

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Pathogen adaptation to lung metabolites

Current Opinion in Microbiology, Journal Year: 2025, Volume and Issue: 85, P. 102608 - 102608

Published: April 4, 2025

Language: Английский

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