Mapping Global Causal Responses to Noninvasive Modulation of Genetically and Spatially Targeted Neural Populations with Sonogenetic-fPET DOI
Yaoheng Yang,

Charlotte Weixel,

Zhongtao Hu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Despite significant progress in brain circuit mapping over recent decades, a major challenge remains: no method currently allows for the noninvasive modulation of genetically and spatially defined neural populations while simultaneously monitoring their global effects throughout body. Here, we present sonogenetic-fPET, technique that integrates sonogenetics with [ 18 F]-2-fluoro-2-deoxy-D-glucose functional positron emission tomography (FDG-fPET) to overcome this challenge. Sonogenetics enables noninvasive, targeted neurons engineered express ultrasound-sensitive ion channel TRPV1, FDG-fPET captures glucose metabolic changes triggered by stimulation across We demonstrate effectiveness targeting dorsal striatum, showcasing its capability map network responses specific neuronal activation. Incorporating an acoustic hologram further flexible different regions within single mouse concurrently resulting activity. In summary, sonogenetic-fPET offers tool dissecting body populations.

Language: Английский

Airy-beam holographic sonogenetics for advancing neuromodulation precision and flexibility DOI Creative Commons
Zhongtao Hu, Yaoheng Yang, Leqi Yang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(26)

Published: June 17, 2024

Advancing our understanding of brain function and developing treatments for neurological diseases hinge on the ability to modulate neuronal groups in specific areas without invasive techniques. Here, we introduce Airy-beam holographic sonogenetics (AhSonogenetics) as an implant-free, cell type–specific, spatially precise, flexible neuromodulation approach freely moving mice. AhSonogenetics utilizes wearable ultrasound devices manufactured using 3D-printed metasurfaces. These are designed manipulate neurons genetically engineered express ultrasound-sensitive ion channels, enabling precise modulation populations. By dynamically steering focus Airy beams through frequency tuning, is capable modulating populations within subregions striatum. One notable feature its flexibly stimulate either left or right striatum a single mouse. This flexibility achieved by simply switching acoustic metasurface device, eliminating need multiple implants interventions. AhSonogentocs also integrates seamlessly with vivo calcium recording via fiber photometry, showcasing compatibility optical modalities cross talk. Moreover, can generate double foci bilateral stimulation alleviate motor deficits Parkinson’s disease advancement significant since many disorders, including disease, involve dysfunction regions. type–specific procedures, provides powerful tool investigating intact neural circuits offers promising interventions disorders.

Language: Английский

Citations

12
The future of transcranial ultrasound as a precision brain interface DOI Creative Commons

Keith E. Murphy,

Elsa Fouragnan

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(10), P. e3002884 - e3002884

Published: Oct. 29, 2024

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.

Language: Английский

Citations

5
High-Resolution Focused Ultrasound Neuromodulation of the Mouse Cortex Induces Lateralized Motor Responses in Awake Mice DOI
Jonas Bendig, Seongyeon Kim,

Samuel G. Blackman

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Editorial for Brain Sciences Special Issue “Advances in Restorative Neurotherapeutic Technologies” DOI Creative Commons
Trenton A. Line, Isabella S. Elkinbard, David Purger

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 273 - 273

Published: March 5, 2025

From Ramon y Cajal and Golgi’s histological techniques to single-cell RNA sequencing, technological innovations have long driven progress in neuroscience [...]

Language: Английский

Citations

0
Bidirectional Lambertian Scatterers Using Acoustic Holograms for the Simultaneous Control of Reflected and Transmitted Wavefronts DOI Open Access
Eric Ballestero, Josep Rodríguez-Sendra, Vicente Romero‐García

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Abstract Acoustic holography enables the creation of tailored spatiotemporal wavefield distributions. In this study, design acoustic holograms that simultaneously control both reflected and transmitted fields are presented. This is accomplished through use a bidirectional metasurface, which encodes phase desired wavefront in discrete spatial distribution monolithic sub‐elements. approach employed particular to an optimized hologram behaves as ideal Lambertian scatter for reflection transmission. The follows quadratic‐residue sequence, with theoretical results validated numerically experimentally. It observed kind structure produces uniform scattering response, high diffusion coefficient approximately 0.7 correlation 0.98 transmission reflection. demonstrates potential significantly reduce imaging artefacts ultrafast ultrasound techniques strongly reverberating environments, evidenced by examples.

Language: Английский

Citations

0
Acoustic Holograms Target Precise Brain Areas with Ultrasound DOI

Dan Hurley

Neurology Today, Journal Year: 2025, Volume and Issue: 25(6), P. 25 - 28

Published: March 20, 2025

Language: Английский

Citations

0
Engineered Living Energy Materials DOI Creative Commons
Xinyi Yuan, Haiyi Xu, Xingwu Liu

et al.

Interdisciplinary materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

ABSTRACT To foster sustainable development, a pivotal trend lies in harnessing energy supplies that propel modern economic and societal progress. Recent advancements living materials for applications have sparked groundbreaking research area: engineered (ELEMs), which seamlessly integrate biological artificial systems efficient conversion storage. consolidate this area, herein, we summarize delve into the evolution of ELEMs. Firstly, provide an overview structural features mechanisms employed by bio‐modules spanning proteins, organelles, entire organisms. They can be directly used as components constructing ELEMs or inspirations design such entities. Then, comprehensively review latest strides based on their distinct modes. Finally, discuss challenges confronting envision future trajectories. The progress holds immense potential to catalyze interdisciplinary endeavors encompassing medicine, environmental science, technologies.

Language: Английский

Citations

0
Transcranial focused ultrasound precise neuromodulation: a review of focal size regulation, treatment efficiency and mechanisms DOI Creative Commons
Jie Jin, Guangying Pei,

Zhenxiang Ji

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 5, 2024

Ultrasound is a mechanical wave that can non-invasively penetrate the skull to deep brain regions activate neurons. Transcranial focused ultrasound neuromodulation promising approach, with advantages of noninvasiveness, high-resolution, and penetration, which developed rapidly over past years. However, conventional transcranial ultrasound's spatial resolution low-precision hinders its use in precision neuromodulation. Here we focus on methods could increase resolution, gain modulation efficiency at focal spot, potential mechanisms In this paper, summarize strategies enhance stimulation, potentially improve technic.

Language: Английский

Citations

1
Simulation Analysis of Thermoacoustic Effect of CNT Film with Metasurface-Enhanced Acoustic Autofocusing DOI Creative Commons

Dalun Rong,

Zhe Li,

Qianshou Qi

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(18), P. 1481 - 1481

Published: Sept. 11, 2024

This study introduces a novel thermoacoustic (TA) focusing system enhanced by Airy beam-based acoustic metasurfaces, significantly improving and efficiency. The integrates TA emitter, fabricated from carbon nanotube (CNT) films, with binary metasurface capable of generating quasi-Airy beams. Through finite element simulations, the system's heat conduction, focusing, self-healing properties were thoroughly analyzed. results demonstrate that achieves superior sub-wavelength tunable focal length via frequency control, robust self-healing, even in presence obstacles. These findings address current limitations emitters suggest broader applications medical ultrasound advanced technology.

Language: Английский

Citations

0
Machine Learning-Enhanced Skull-Universal Acoustic Hologram for Efficient Transcranial Ultrasound Neuromodulation Across Varied Rodent Skulls DOI
Moon Hwan Lee, Kyungsu Lee,

Youngseung Yoo

et al.

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Journal Year: 2024, Volume and Issue: 72(1), P. 127 - 140

Published: Dec. 2, 2024

Ultrasound neuromodulation (UNM) has gained significant interest in brain science due to its non-invasive nature, precision, and deep stimulation capabilities. However, the skull poses challenges along acoustic path, leading beam distortion necessitating effective aberration correction. Acoustic holograms used with single-element ultrasound transducers offer a promising solution by enabling both correction multi-focal stimulation. A major limitation, however, is that hologram lenses designed for specific skulls may not perform well on other skulls, requiring multiple custom scaled studies. To address this, we introduce Skull-Universal Hologram (SUAH), which enables efficient transcranial UNM across various types. Our generation framework integrates physics-based hologram, differentiable simulation heterogeneous media, gradient accumulation technique. SUAH, trained range of rodent shapes, demonstrated remarkable generalizability robustness, even outperforming Skull-Specific (SSAH). Through comprehensive analyses, showed SUAH performs exceptionally well-even when smaller datasets-significantly training based individual skulls. In conclusion, shows promise as scalable, versatile, accurate tool neuromodulation, representing advancement over conventional single-skull lenses. Its ability adapt different types without need potential greatly facilitate research neuromodulation.

Language: Английский

Citations

0