Unlocking the therapeutic potential of edible mushrooms: Ganoderma and their secondary metabolites as novel antiviral agents for combating COVID-19 DOI
Samantha C. Karunarathna, Wenhua Lu,

Nimesha Patabedige

et al.

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 59

Published: Aug. 8, 2024

The global COVID-19 pandemic, caused by SARS-CoV-2, has created an urgent need for novel antiviral agents, as it led to a devastating loss of lives worldwide. In response, numerous vaccines were developed in 2022, with ongoing efforts more candidates. Despite significant progress, reports vaccine-related issues and side effects have emerged. effectiveness been challenged new viral variants, lack well-designed vivo experiments, randomised controlled trials. Currently, no clinically approved medications exist treating COVID-19. However, few broad-spectrum drugs shown promising outcomes clinical studies. Many scientists believe that natural compounds derived from herbal medicines mushrooms could offer substantial benefits patients. Ganoderma, known its traditional use promoting health longevity, rich history therapeutic applications dietary supplementation. Numerous epidemiological studies demonstrated Ganoderma derivatives can enhance innate adaptive immune responses against various pathogens, including viruses, laboratory settings living organisms. Therefore, the secondary metabolites such triterpenoids, polysaccharides, glycoproteins, hold potential developing drugs. These mechanisms, inhibition replication, modulation responses, direct virucidal effects. Given search effective treatments COVID-19, bioactive stand out candidates further research development. Their multifaceted mechanisms make them suitable exploration agents potentially contributing enhancing existing treatments.

Language: Английский

Plant polyphenols, terpenes, and terpenoids in oral health DOI Creative Commons
Vida Arzani, Mohsen Soleimani, Tilman Fritsch

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Abstract Introduction Herbal products are increasingly being used for their potential to promote oral health. Phytochemicals can act as scavengers of reactive or toxic chemicals, selective growth factors beneficial bacteria, fermentation substrates and inhibitors harmful microflora. Plant-derived secondary metabolites encompass a variety natural products, including alkaloids, polyphenols (including flavonoids tannins), terpenes, terpenoids, steroids, saponins, quinones, coumarins, glycosides, carotenoids. Objectives This review explores medicinal plant-based preventing treating diseases, offering updated insights into the scientific basis using herbs active ingredients in health care. Hence, we focused on: (1) phenolic compounds, most abundant common phytochemicals (2) terpenes diverse widely distributed group plant kingdom. Methods Several databases were queried acquire peer-reviewed studies focusing on major phytochemical compositions – terpenoids benefits. Results The lists numerous various forms applications dental caries, gingivitis, periodontitis. Conclusion evidence supporting health-promoting effects specific constituents with incorporation pharmaceutical formulations.

Language: Английский

Citations

1
Evaluation of anticancer and antibacterial activities of different strains of Ganoderma isolated from Caspian Hyrcanian forests DOI
Maliheh Safavi, Mahroo Seyed Jafari Olia,

Farzaneh Azizmohseni

et al.

New Zealand Journal of Botany, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 9, 2025

In the present study, extracts from 10 Ganoderma spp. isolates were tested for their cytotoxic effects on various human cancer cell lines. The MTT assay was used to quantify viability. Fluorescence microscopy and flow cytometry demonstrated apoptosis in treated antibacterial efficacy of examined against different gram-positive negative bacteria. ethyl acetate extract strain PTCC 6009 most effective agent MDA-MB-231 line, with an IC50 314.88 µg/mL. Cells incubated dose showed percentages early late at 24 h, values 43.6% 2.3%, respectively. methanol 6001 (at concentration 250 mg/mL) activity Bacillus subtilis (PTCC 1715) inhibition zone 21.28 mm. These findings indicate potential therapeutic properties isolated strains further pharmacological studies.

Language: Английский

Citations

0
Soybean hull polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed zebrafish DOI
Chen Chen, Hong Song, Lina Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141123 - 141123

Published: Feb. 1, 2025

Language: Английский

Citations

0
Artificial intelligence-driven innovation in Ganoderma spp.: potentialities of their bioactive compounds as functional foods DOI Creative Commons
Sonali Khanal, Aman Sharma,

M. Radhakrishna Pillai

et al.

Sustainable Food Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

AI significantly transforms the food business by optimizing production processes of therapeutic Ganoderma spp. and improving quality safety control based functional food.

Language: Английский

Citations

0
Current perspectives on malnutrition and immunomodulators bridging nutritional deficiencies and immune health DOI Creative Commons
Ashish Majumdar,

Surendra Saraf,

Chandrashekhar Sahu

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 24, 2025

Abstract Background Malnutrition is still one of the most serious and prevalent worldwide health problems, especially found in low- middle-income countries, which impairs immune functions increases susceptibility to infection. This study investigates complex association between malnutrition dysfunction, role immunomodulators restoring function. analyzes different types malnutrition, including protein-energy micronutrient deficiencies, their consequences system through inhibited cytokine cell production. Main body Immunomodulators, include natural agents such as phytochemicals probiotics, well synthetic agents, may help reduce dysfunction related starvation. article categorizes these discusses mechanisms action, regulating inflammatory pathways, increasing generation cells, augmenting global response. In addition, therapeutic approaches utilizing immunomodulation conjunction with nutritional therapies, supplementation (vitamins A, C, D zinc) or immunomodulators, improve gastroenterological disease states are discussed. Case reports recent studies provided that provide evidence supporting effectiveness therapy clinical outcomes vulnerable populations. Conclusion While there a promise for safety, long-term efficacy, ethical issues address before they could widely be employed. Each step research calls applied, working example immunomodulatory medicine tailored programs internationally. The highlights vital treatment encourages holistic immunological worldwide.

Language: Английский

Citations

0
Ganodermataceae—current status, research, and development in Lower Mekong Basin DOI Creative Commons
Samantha C. Karunarathna, Nimesha M. Patabendige, Thatsanee Luangharn

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 12, 2025

The family Ganodermataceae encompasses several genera, including the widely studied Ganoderma , which is prominent in traditional medicine for its therapeutic properties. Species within this family, particularly lucidum have been valued centuries regions such as China, Korea, and Japan enhancing vitality, longevity, overall health. However, taxonomy of remains complex, with ongoing debates about species identification classification. Members are globally distributed, Lower Mekong Basin—comprising Laos, Thailand, Cambodia, Vietnam—offering optimal conditions their growth due to warm, humid climate. In Basin, significant medicinal applications treating bronchitis, hepatitis, diabetes, cancer. They also hold economic value, being used products like teas, dietary supplements, cosmetics. notable a high-value market product region. Recent research has revealed rich diversity region, highlighting ecological roles, properties, importance plant pathology, addressing diseases crops oil palm. These findings underscore need further into taxonomy, functions, potential species. Advancing our understanding will support sustainable utilization, conservation efforts, maximization commercial benefits.

Language: Английский

Citations

0
The Impact of Ganoderma lucidum (Curtis) P. Karst. Supplementation on the Technological, Chemical, and Quality Parameters of Wheat Bread DOI Creative Commons
Paulina Łysakowska, Aldona Sobota, Anna Wirkijowska

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3101 - 3101

Published: Sept. 28, 2024

This study explores the incorporation of Ganoderma lucidum (Curtis) P. Karst. (Reishi mushroom) into wheat bread to develop a functional food with enhanced nutritional value. Reishi powder was added formulations at levels 3%, 6%, 9%, and 12% assess its effects on physicochemical, nutritional, sensory properties. The supplementation resulted in twofold increase total dietary fibre (from 7.21 g 17.08 per 100 dry matter) significant (p < 0.05) elevations mineral content, particularly calcium (68%), iron (32%), manganese (61.9%). Carbohydrate content decreased markedly by 27%, contributing 19.33% reduction caloric addition improved yield reduced baking losses, enhancing production efficiency. However, higher negatively impacted volume, possibly due interference gluten network formation. An crumb moisture observed, extended freshness. Sensory evaluation revealed that loaves containing up 6% were acceptable consumers, whereas detrimentally affected flavour aroma. Therefore, Reishi-enriched bread, supplementation, presents promising alternative conventional optimising benefits while maintaining consumer acceptability.

Language: Английский

Citations

3
Unlocking the therapeutic potential of edible mushrooms: Ganoderma and their secondary metabolites as novel antiviral agents for combating COVID-19 DOI
Samantha C. Karunarathna, Wenhua Lu,

Nimesha Patabedige

et al.

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 59

Published: Aug. 8, 2024

The global COVID-19 pandemic, caused by SARS-CoV-2, has created an urgent need for novel antiviral agents, as it led to a devastating loss of lives worldwide. In response, numerous vaccines were developed in 2022, with ongoing efforts more candidates. Despite significant progress, reports vaccine-related issues and side effects have emerged. effectiveness been challenged new viral variants, lack well-designed vivo experiments, randomised controlled trials. Currently, no clinically approved medications exist treating COVID-19. However, few broad-spectrum drugs shown promising outcomes clinical studies. Many scientists believe that natural compounds derived from herbal medicines mushrooms could offer substantial benefits patients. Ganoderma, known its traditional use promoting health longevity, rich history therapeutic applications dietary supplementation. Numerous epidemiological studies demonstrated Ganoderma derivatives can enhance innate adaptive immune responses against various pathogens, including viruses, laboratory settings living organisms. Therefore, the secondary metabolites such triterpenoids, polysaccharides, glycoproteins, hold potential developing drugs. These mechanisms, inhibition replication, modulation responses, direct virucidal effects. Given search effective treatments COVID-19, bioactive stand out candidates further research development. Their multifaceted mechanisms make them suitable exploration agents potentially contributing enhancing existing treatments.

Language: Английский

Citations

1