Anticancer Properties of Macroalgae: A Comprehensive Review DOI Creative Commons
Sara Frazzini, Luciana Rossi

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 70 - 70

Published: Feb. 7, 2025

In recent years, the exploration of bioactive molecules derived from natural sources has gained interest in several application fields. Among these, macroalgae have garnered significant attention due to their functional properties, which make them interesting therapeutic applications, including cancer treatment. Cancer constitutes a global health burden, and side effects existing treatment modalities underscore necessity for novel models that, line with goal reducing drug treatments, take advantage compounds. This review explores anticancer properties macroalgae, focusing on compounds mechanisms action. The key findings suggest that possess rich array compounds, polysaccharides (e.g., fucoidans alginates), polyphenols phlorotannins), terpenoids, exhibit diverse activities, such as inhibition cell proliferation, angiogenesis, induction apoptosis, modulation immune system. provides an overview current understanding macroalgae’s potential, highlighting most promising While preclinical studies shown results, further research is necessary translate these into effective clinical applications.

Language: Английский

Seaweeds as Nutraceutical Elements and Drugs for Diabetes Mellitus: Future Perspectives DOI Creative Commons
João Cotas, Silvia Lomartire, Leonel Pereira

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 168 - 168

Published: April 10, 2024

Diabetes mellitus is a chronic metabolic condition marked by high blood glucose levels caused inadequate insulin synthesis or poor use. This affects millions of individuals worldwide and linked to variety consequences, including cardiovascular disease, neuropathy, nephropathy, retinopathy. therapy now focuses on controlling through lifestyle changes, oral medicines, injections. However, these therapies have limits may not successfully prevent treat diabetic problems. Several marine-derived chemicals previously demonstrated promising findings as possible antidiabetic medicines in preclinical investigations. Peptides, polyphenols, polysaccharides extracted from seaweeds, sponges, other marine species are among them. As result, natural products the potential be rich source innovative multitargeted medications for diabetes prevention treatment, well associated complications. Future research should focus chemical creatures mechanisms action order find new maximize their therapeutic potential. Based investigations, this review next step seaweed applications diabetes, highlighting bioactivities seaweeds treatment illness.

Language: Английский

Citations

7

Algal carbohydrates: Sources, biosynthetic pathway, production, and applications DOI
Pradip Sarkar, Tarun Kanti Bandyopadhyay,

K. Gopikrishna

et al.

Bioresource Technology, Journal Year: 2024, Volume and Issue: unknown, P. 131489 - 131489

Published: Sept. 1, 2024

Language: Английский

Citations

7

An Overview of Biostimulants’ Effects in Saline Soils DOI Creative Commons

Abdelbasset Lakhdar,

Mohamed Trigui, Francesco Montemurro

et al.

Agronomy, Journal Year: 2023, Volume and Issue: 13(8), P. 2092 - 2092

Published: Aug. 9, 2023

The unsustainable use of natural resources and their overexploitation continue to be major threats global agriculture development. This practice increases the abiotic stresses, resulting both in crop yield losses soil degradation. Low productivity is often associated with salinized soil, which caused by toxic osmotic effects soluble salt accumulation and, consequently, lack organic matter. Conversely, there a need improve current meet increasing food demands. Among methodologies proposed increase plant resistance stress, utilization production biostimulants has been recently proposed. These are products mainly based on algae, microorganisms, fulvic humic acids, proteins, amino acids that physiological performance, leading increased productivity. positive benefits, application can also reduce usage conventional chemical fertilizers. aim this work was present different saline conditions. In particular, review, we report critically discuss most recent research dealing growth salinity resistance.

Language: Английский

Citations

15

Nutritional and Antioxidative Benefits of Dietary Macroalgae Supplementation in Weaned Piglets DOI Creative Commons
Anna Czech,

Katarzyna Woś,

Siemowit Muszyński

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(4), P. 549 - 549

Published: Feb. 7, 2024

This study explores the effects of dietary brown macroalgae (Ascophyllum nodosum) inclusion on digestibility and blood biochemical indices redox markers in piglets fed diets with varying levels (0%, 0.6% 1%) from 18 to 64 days age. Macroalgae significantly influenced lipid profiles, reducing total cholesterol (quadratic contrast p = 0.001) demonstrating an increase high-density lipoprotein levels, particularly 1% (linear < 0.001), a decrease low-density both macroalgae-supplemented groups 0.001). Additionally, had positive impact activities antioxidative enzymes (ferric-reducing ability plasma, superoxide dismutase, reduced glutathione) peroxidation products (lipid hydroperoxide, malondialdehyde) blood, liver tissue, intestinal epithelium ileum, suggesting enhanced defense mechanisms. These changes were dose-dependent; they exhibited linear quadratic response, while tissues, response was primarily linear. crude fat observed highlighting their potential role improving nutrient absorption digestion. The findings emphasize health benefits natural, seaweed-based additives diets, managing oxidative stress highlight as natural supplement improve antioxidant systems metabolism piglets.

Language: Английский

Citations

5

Exploring the modulatory effects of brown seaweed meal and extracts on intestinal microbiota and morphology of broiler chickens challenged with heat stress DOI Creative Commons

Fisayo T. Akinyemi,

Deborah Adewole

Poultry Science, Journal Year: 2024, Volume and Issue: 103(4), P. 103562 - 103562

Published: Feb. 16, 2024

Brown seaweed (Ascophyllum nodosum) is known for its prebiotic roles and can improve animal intestinal health by enhancing the growth of beneficial microbes inhibiting pathogenic ones. However, gut health-modulatory brown on chickens challenged with heat stress (HS) are rarely studied. The current study examined effects meal (SWM) extract (SWE) ceca microbiota small morphology or unchallenged HS. Three hundred thirty-six 1-day-old Ross 308 broiler chicks were randomly assigned to either a thermoneutral (TN; 24 ± 1°C); HS room (HS; 32-34°C, 8 h/d from d 21 27). All birds in each allotted 4 treatments - control (CON), CON + 1 mL/L drinking water, 2 SWE 2% feed raised 28 d. On 14 28, 12 per treatment group, respectively, euthanized collect content analysis tissues morphological examination. 14, SWM increased (P = 0.047) relative abundance cecal Fecalibacterium all improved jejunal villus height (VH) VH:CD compared diet. significantly reduced < 0.05) ileal VH, VW, VH:CD, duodenal VH VH:CD. Among Lactobacillus, Sellimonas, Fournierella, fed had higher other treatments. In summary, enhanced among chickens. This implies that could potentially alleviate HS-induced impairment

Language: Английский

Citations

5

Effects of brown seaweed products on growth performance, plasma biochemistry, immune response, and antioxidant capacity of broiler chickens challenged with heat stress DOI Creative Commons

Fisayo T. Akinyemi,

Deborah Adewole

Poultry Science, Journal Year: 2022, Volume and Issue: 101(12), P. 102215 - 102215

Published: Sept. 30, 2022

Brown seaweed (Ascophyllum nodosum) is an exceptional bioactive substance known for its excellent antioxidant ability. Given the potential benefits of brown seaweed, current study was conducted to determine efficacy on growth performance, blood biochemistry, immunoglobulins (IgG and IgM), capacity broiler chickens challenged with heat stress (HS). A total 336 mixed-sex Ross 308 chicks (one-day-old) were randomly assigned into two groups; The thermoneutral group (TN, broilers raised at 24 ± 1°C); (HS; exposed 32°C 34°C, 8 h/d from day 21 27; temperature in remaining time same as TN group). All birds each allotted 4 dietary treatments—Negative control (NC) (without seaweed), NC + 1 mL extract (SWE) drinking water, 2 SWE 2% meal (SWM) feed. Each treatment six replicates 7 broilers/replicate. Average body weight gain (ABWG), average feed intake (AFI), water (AWI), conversion ratio (FCR), mortality determined weekly. On 28, male birds/cage euthanized collect immune organs subsequent biochemical, antioxidant, status analysis. Data analyzed a × factorial analysis variance using GLM procedure Minitab software. Overall, SWM inclusion significantly increased (P < 0.05) AFI, ABWG, AWI irrespective HS. HS reduced AFI bird's rectal temperature, plasma concentrations sodium, chloride, glucose, amylase, uric acid compared birds. serum IgM IgG decreased glutathione reductase peroxidase birds, while activity superoxide dismutase not affected by treatments. alanine aminotransferase gamma-glutamyl transferase heat-stressed broilers, respectively other Conclusively, supplementation improved performance may help reduce negative effects improving enzyme activities

Language: Английский

Citations

21

A systematic review of fucoxanthin as a promising bioactive compound in drug development DOI

HS Kumarasinghe,

Mdtl Gunathilaka

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 61, P. 52 - 65

Published: March 22, 2024

Language: Английский

Citations

4

Eco-friendly nutrient from ocean: Exploring Ulva seaweed potential as a sustainable food source DOI Creative Commons
Nida Tabassum Khan, K. Sudhakar, Rizalman Mamat

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 17, P. 101239 - 101239

Published: June 5, 2024

Growing environmental concerns and a desire for health-conscious food choices are driving consumer demand sustainable ethical sources. Ulva seaweed (genus Ulva, Phylum Chlorophyta) emerges as promising candidate due to its rich nutritional profile, which includes proteins, carbohydrates, lipids, antioxidants. This review explores the immense potential of an eco-friendly nutritious source with applications in industry. Focusing on viability solution, we explore Ulva's biochemical composition, health benefits beyond established nutrition, role product development. While challenges remain, including variability nutrient content, efficient harvesting processing methods, ensuring safety, minimal impact high value make it compelling alternative. Furthermore, recent studies reveal unique compounds possess impressive benefits, antioxidant, antimicrobial, antiviral properties, offer exciting possibilities human health. integration cultivation Integrated Multitrophic Aquaculture (IMTA) systems demonstrates feasibility large-scale production while enhancing sustainability. Additionally, seaweed's compounds, properties like effects, offering provides valuable insights researchers exploring seaweed, readily available natural resource that holds address global malnutrition without compromising ecosystem's

Language: Английский

Citations

4

Synergistic effect of green synthesis magnesium oxide nanoparticles and seaweed extract on improving water quality, health benefits, and disease resistance in Nile tilapia DOI Creative Commons
Mahmoud Radwan, Moussa Attia Moussa, Eman A. Manaa

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 280, P. 116522 - 116522

Published: June 5, 2024

This study aimed to evaluate the effect of adding liquid extract algae (Hypnea musciformis, Grateloupia acuminata, and Sargassum muticum) (HGS) Magnesium oxide nanoparticles (MgO NPs) using this rear water Oreochromis niloticus, on improving culture indices, growth performance, digestive enzyme, hemato-biochemical characters, immune, antioxidative responses, resistance after challenged by Aeromonas hydrophila with specific refer potential role mixture in vitro as against three strains bacteria (Aeromonas sobria, Pseudomonas fluorescens, P. aeruginosa) one parasite (Cichlidogyrus tilapia). The first group represented control, HGS0, whereas other group, HGS5, HGS10, HGS15 mL

Language: Английский

Citations

4

The Eliciting Effect of Aqueous Extracts from Ascophyllum nodosum Algae on the Cultivation of Arugula (Eruca sativa Mill.) Microgreens DOI Open Access
Barbara Drygaś, Tomasz Piechowiak, Maciej Balawejder

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(17), P. 7436 - 7436

Published: Aug. 28, 2024

This study showed the eliciting effect of aqueous extracts from Ascophyllum nodosum on development Eruca sativa microgreens in a quartz-based substrate. There is no information literature impact its use quality, bioactive compound content, and nutritional value arugula microgreens. Assays that have been made include following: total phenolic content (TPC), flavonoid (TFV), enzymes such as phenylalanine ammonia (PAL) polyphenol oxidase (PPO), involved scavenging reactive oxygen species catalase (CAT) superoxide dismutase (SOD). The antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) was also evaluated. increased significantly after an application A. to greatest increase (89%) (82%) observed at concentration 2.5%. highest CAT (68.2%), SOD (25%), PAL (13-fold), PPO (84.2%) with 5% extract. In conclusion, algae affects TPC TFV, activity, PAL, PPO, SOD, studied. By prioritising organic environmentally friendly extracts, growers can contribute more sustainable healthier food system, especially case production

Language: Английский

Citations

4