A physically cross-linked double network polysaccharides/Ca2+ hydrogel scaffold for skeletal muscle tissue engineering

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2023, Volume and Issue: 668, P. 131410 - 131410

Published: April 8, 2023

Language: Английский

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Non-Fourier Bioheat Transfer Analysis in Brain Tissue During Interstitial Laser Ablation: Analysis of Multiple Influential Factors

Annals of Biomedical Engineering, Journal Year: 2024, Volume and Issue: 52(4), P. 967 - 981

Published: Jan. 18, 2024

This work presents the dual-phase lag-based non-Fourier bioheat transfer model of brain tissue subjected to interstitial laser ablation. The finite element method has been utilized predict tissue's temperature distributions and ablation volumes. A sensitivity analysis conducted quantify effect variations in input power, treatment time, fiber diameter, wavelength, phase lags. Notably, this work, temperature-dependent thermal properties have considered. developed validated by comparing obtained from numerical ex vivo during further extended settings incorporating blood perfusion effects. results systematic highlight importance considering tissue, behavior, microvascular effects computational models for accurate predictions outcomes ablation, thereby minimizing damage surrounding healthy tissue. parametric reported study would assist a more precise prediction distribution, thus allowing optimize dosage therapy brain.

Language: Английский

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Intracellular Heat Transfer and Thermal Property Revealed by Kilohertz Temperature Imaging with a Genetically Encoded Nanothermometer

Nano Letters, Journal Year: 2022, Volume and Issue: 22(14), P. 5698 - 5707

Published: July 6, 2022

Despite improved sensitivity of nanothermometers, direct observation heat transport inside single cells has remained challenging for the lack high-speed temperature imaging techniques. Here, we identified insufficient resolution under short signal integration time and slow sensor kinetics as two major bottlenecks. To overcome limitations, developed B-gTEMP, a nanothermometer based on tandem fusion mNeonGreen tdTomato fluorescent proteins. We visualized propagation intracellular space by tracking temporal variation local at 155 μs 0.042 °C. By comparing fast in situ dynamics with computer-simulated diffusion, estimated thermal diffusivity live HeLa cells. The present was about 1/5.3 that water much smaller than values reported bulk tissues, which may account observations heterogeneous distributions.

Language: Английский

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Strong correlation between specific heat capacity and water content in human tissues suggests preferred heat deposition in malignant tumors upon electromagnetic irradiation

International Journal of Hyperthermia, Journal Year: 2022, Volume and Issue: 39(1), P. 987 - 997

Published: July 24, 2022

Tumor perfusion is considered to be the principal factor determining build-up of therapeutically effective thermal fields. This assumes that malignancies have lower perfusions than their homologous tissues. assumption, however, ignores fact several tumor types higher healthy counterparts. Additionally, flow changes upon hyperthermia (39-43 °C) are non-predictable and extremely heterogeneous. Therefore, modeling temperature distribution further requires a more robust parameter, different in tissues, i.e., water content (Cw), which highly determines properties electromagnetic irradiation.Systematic literature reviews Cw specific heat capacities (cp) were conducted up 28 February 2022, providing an updated, comprehensive data overview based on original manuscripts, databases.Cw- cp-values cancers corresponding tissues presented. Strong correlations between these two parameters described. In general, malignant tumors distinctly values With increasing low-water-content normal (<70 wt.%), cp rises exponentially from 1.5 3.3 J·g-1·K-1. high-water-content (≥70 increases linearly 3.5 3.8 (>80 3.6 3.9 Cancers contain 27% origin must as 'high-capacitance-tissues'.Hyperhydration result cp-values, causing better reservoirs irradiation. Reliable, tissue-/cancer-specific when distributions hyperthermic treatment.

Language: Английский

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Temperature Dependence of Thermal Properties of Ex Vivo Porcine Heart and Lung in Hyperthermia and Ablative Temperature Ranges

Annals of Biomedical Engineering, Journal Year: 2023, Volume and Issue: 51(6), P. 1181 - 1198

Published: Jan. 19, 2023

This work proposes the characterization of temperature dependence thermal properties heart and lung tissues from room up to > 90 °C. The diffusivity (α), conductivity (k), volumetric heat capacity (Cv) ex vivo porcine hearts deflated lungs were measured with a dual-needle sensor technique. α k associated tissue remained almost constant until ~ 70 80 °C, accordingly. Above more substantial variation in these was registered: at 94 respectively experienced 2.3- 1.5- fold increase compared their nominal values, showing average values 0.346 mm2/s 0.828 W/(m·K), Conversely, Cv 55 °C decreased afterward (e.g., = 2.42 MJ/(m3·K) °C). Concerning tissue, both its characterized by an exponential temperature, marked increment supraphysiological ablative temperatures (at 91 equal 2.120 2.721 respectively, i.e., 13.7- 13.1-fold higher baseline values). Regression analysis performed attain best-fit curves interpolating data, thus providing models investigated properties. These can be useful for increasing accuracy simulation-based preplanning frameworks interventional procedures, realization tissue-mimicking materials.

Language: Английский

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Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT)

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 25, 2023

Abstract Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve clinical efficiency and safety such minimally invasive therapies. We present a method automatically regulate in vivo increase LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution 1.4 mmx1.4 mm slice thickness 3 mm) proton-resonance frequency (PRF) shift technique. The laser output power is adjusted second feedback algorithm (proportional-integral-derivative controller) force maximal targeted region follow predefined temperature–time profile. root-mean-square difference between target measured ranged 0.5 °C °C, for increases + 5 30 above body long heating duration (up 15 min), showing excellent accuracy stability method. These results were obtained on 1.5 T MRI scanner, immediate application controller MR-guided LITT.

Language: Английский

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Incorporating temperature-dependent properties into the modeling of photo-thermo-mechanical interactions in cancer tissues

Thermal Science and Engineering Progress, Journal Year: 2023, Volume and Issue: 47, P. 102351 - 102351

Published: Dec. 21, 2023

Language: Английский

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Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

Functional Composite Materials, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 31, 2024

Abstract Heat-based local ablation techniques are effective treatments for specific oligometastatic and localized cancers being studied their potential to induce immunogenic cell death augment systemic immune responses immunotherapies. The diverse technologies associated with thermal therapy have an unmet need method development enable device-specific experimentation, optimization, calibration refinement of the parameter space optimize therapeutic intent while minimizing side effects or risk patient. Quality assurance, training, comparing dose among different modalities using animal models is time resource intensive. Therefore, application use tissue mimicking thermosensitive, thermochromic liquid crystal paint phantom may reduce costs hurdles use. Further, homogenous composition more precise assessment ablative techniques. This review utilized SciFinder, Web Science, PubMed EMBASE systematically evaluate literature describing background applications crystal, tissue-mimicking phantoms used characterize devices a focus on facilitating across medical device life cycle. Graphical

Language: Английский

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Near‐Infrared Nanoparticle‐Mediated Photothermal Cancer Therapy: A Comprehensive Review of Advances in Monitoring and Controlling Thermal Effects for Effective Cancer Treatment

Nano Select, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

ABSTRACT Photothermal therapy (PTT) has emerged as a promising alternative to conventional cancer treatments such radiation therapy, chemotherapy, and surgery. PTT uses light‐absorbing nanomaterials induce localized hyperthermia selectively eliminate cells, thus offering advantages over traditional interventions. This literature review focuses on nanoparticles for PTT, their heating properties, functions in theragnostic applications photothermal treatment. It highlights the fundamental principles, recent spectroscopic developments diagnosis treatment monitoring, clinical advancements near‐infrared (NIR) nanoparticle‐mediated emerging numerical methods preclinical planning of PTT.

Language: Английский

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Fiber Bragg Grating Thermometry and Post-Treatment Ablation Size Analysis of Radiofrequency Thermal Ablation on Ex Vivo Liver, Kidney and Lung

Sensors, Journal Year: 2025, Volume and Issue: 25(1), P. 245 - 245

Published: Jan. 3, 2025

Radiofrequency ablation (RFA) is a minimally invasive procedure that utilizes localized heat to treat tumors by inducing tissue thermal damage. The present study aimed evaluate the temperature evolution and spatial distribution, size, reproducibility of zones in ex vivo liver, kidney, lung using commercial device, i.e., Dophi™ R150E RFA system (Surgnova, Beijing, China), compare results with manufacturer’s specifications. Optical fibers embedding arrays fiber Bragg grating (FBG) sensors, characterized 0.1 °C accuracy 1.2 mm resolution, were employed for thermometry during procedures. Experiments conducted all organs two different configurations: single-electrode (200 W 12 min) double-electrode 9 min). Results demonstrated consistent reproducible across organ types, variations distribution size influenced characteristics settings. Higher temperatures achieved liver; conversely, exhibited smallest zone lowest maximum temperatures. found electrodes min produced larger, more rounded areas compared single electrode min. Our findings support efficacy highlight need tailored parameters based on type tumor properties. This research provides insights into characterization systems optimizing techniques underscores importance accurate precise procedural planning enhance clinical outcomes.

Language: Английский

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