Noninvasive Ultra Low Intensity Light Photodynamic Treatment of Glioblastoma with Drug Augmentation: LoGlo PDT Regimen DOI Creative Commons
Richard E. Kast,

Anton Kast,

Jürgen Arnhold

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1164 - 1164

Published: Nov. 21, 2024

This paper presents the basis for LoGlo PDT, a new treatment glioblastoma. Glioblastoma is currently treated with maximal safe resection, temozolomide, and ionizing irradiation. Mortality in 2024 remains over 80% within several years from diagnosis. Oral 5-aminolevulinic acid (5-ALA) an FDA/EMA approved drug that selectively taken up by malignant cells, including In photodynamic of glioblastoma, intense intraoperative light causes glioblastoma tissue has 5-ALA to generate cytotoxic reactive oxygen species. The requirement flux restricted single one-hour session. We analyze here published data showing external light, illuminating entire intact scalp, can attain low μW/cm2 cm into brain would be sufficient mediate if are delivered continuously 24 h. At core PDT regimen dataset that, given fluence, as duration delivery goes down, intensity (flux) must go achieve same cell cytotoxicity weaker (lower flux) longer time. Thus, repetitive, noninvasive using source may possible. cellular physiology show three non-oncology drugs, ciprofloxacin, deferiprone, telmisartan, repurposed increase energy capture after 5-ALA, thereby increasing treatment’s cytotoxicity. approach uses both augmentation prolonged ultra-low transcranial

Language: Английский

The changing treatment landscape of EGFR-mutant non-small-cell lung cancer DOI
Fei Zhou, Haoyue Guo, Yang Xia

et al.

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

Citations

10
ALDH1A1 in breast cancer: A prospective target to overcome therapy resistance (Review) DOI Open Access
Lokman Varışlı,

Panagiotis Zoumpourlis,

Demetrios�� Spandidos

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(5), P. 1 - 17

Published: March 4, 2025

The expression of cytosolic aldehyde dehydrogenases (ALDHs), which mediate the last step in pathway synthesis all‑trans retinoic acid, is dysregulated various types human cancer, and has been associated with development cancer stem cells (CSCs) solid tumors hematological malignancies. CSCs are considered a minor fraction capacity to initiate neoplastic tumors. ALDH1A1 serves crucial role emergence CSC phenotype, induces malignant behavior promotes treatment resistance. Notably, ALDH1A1‑induced therapy resistance not exclusive just one group drugs, but affects diverse drugs that use different mechanisms kill cells. This diversity drug resistance‑inducing effects stemness‑supporting functions ALDH1A1. inhibition activity using chemicals or depletion via genetic approaches, such as small interfering RNA, can overcome pathways In context breast it critical only expected manifest stem‑like features, include increased From angle disease prognosis, extent association remains be determined through application cutting‑edge methods detect tracked biomarkers within

Language: Английский

Citations

1
Computational investigations of flavonoids as ALDH isoform inhibitors for treatment of cancer DOI
Magdi Awadalla Mohamed, Tilal Elsaman, Malik Suliman Mohamed

et al.

SAR and QSAR in environmental research, Journal Year: 2024, Volume and Issue: 35(10), P. 837 - 875

Published: Oct. 2, 2024

Human aldehyde dehydrogenases (ALDHs) are a group of 19 isoforms often overexpressed in cancer stem cells (CSCs). These enzymes play critical roles CSC protection, maintenance, progression, therapeutic resistance, and poor prognosis. Thus, targeting ALDH offers potential for innovative treatments. Flavonoids, known their ability to affect multiple cancer-related pathways, have shown anticancer activity by downregulating specific isoforms. This study aimed evaluate 830 flavonoids from the PubChem database against five (ALDH1A1, ALDH1A2, ALDH1A3, ALDH2, ALDH3A1) using computational methods identify potent inhibitors. Extra precision (XP) Glide docking MM-GBSA free binding energy calculations identified several with high affinities. MD simulation highlighted 1, 2, 18, 27, 42 as inhibitors each isoform, respectively. Flavonoid 10 showed affinities ALDH3A1, emerging multi-ALDH inhibitor. ADMET property evaluation indicated that promising hits acceptable drug-like profiles, but further optimization is needed enhance efficacy reduce toxicity, making them more effective future treatment.

Language: Английский

Citations

3
Applications of Molecular Docking Studies in SARS-CoV-2 Targeted Drug Discovery and the Gains Achieved through Molecular Docking DOI Creative Commons

Merve Yildirim,

İsmail Çeli̇k

Biomedical engineering, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

In this chapter, we delve into the pivotal role of molecular docking in realm computational biology and chemistry, focusing specifically on its application drug discovery targeting SARS-CoV-2. Molecular docking, a critical technique, has played significant predicting interactions bindings molecules, particularly concerning SARS-CoV-2’s main protease RNA polymerase. This chapter highlights synergy between virtual screening, emphasizing expedited identification evaluation potential candidates against Through comprehensive discussion, aim to provide nuanced understanding rapid advancements for SARS-CoV-2, accentuating indispensable value tools methods contemporary therapeutic development.

Language: Английский

Citations

1
Unraveling new avenues in pancreatic cancer treatment: A comprehensive exploration of drug repurposing using transcriptomic data DOI

Naina Sunildutt,

Faheem Ahmed,

Abdul Rahim Chethikkattuveli Salih

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 185, P. 109481 - 109481

Published: Dec. 6, 2024

Language: Английский

Citations

1
The inhibitory activities of two compounds from Securidaca longepedunculata Fresen on the acetylcholinesterase from wheat pest Schizaphis graminum Rondani: in silico analysis DOI Creative Commons

Rasmané Guiré,

Pousbila Salo,

Eliasse Zongo

et al.

Plant Signaling & Behavior, Journal Year: 2024, Volume and Issue: 20(1)

Published: Dec. 19, 2024

Wheat is the third most widely consumed cereal in world, after maize and rice. However, it regularly attacked by wheat aphid (Schizaphis graminum), causing considerable damage to crops. The acetylcholinesterase enzyme, which plays a key role transmission of synaptic cholinergic signal, has emerged as promising target for development pest control strategies. Inhibition this enzyme leads paralysis or even death aphid. objective study identify bioactive compounds Securidaca longepedunculata (S. longepedunculata) that are capable interacting with from Schizaphis graminum inhibiting its activity. Furthermore, computer simulation these interaction protein was conducted. First, secondary metabolites S. were selected on basis GC-MS data available specific reference sources. Subsequently, subjected virtual screening based their docking scores order those inhibitory properties. highest molecular dynamics over 50 ns trajectory. MMGBSA free energy calculations results demonstrated eight exhibited properties, four (echimidine, populin, salidroside, farrerol) superior stabilizing effects proteins compared remaining compounds. In terms simulation, observed echimidine populin formed robust stable hydrogen bonds amino acids enzyme. This identifies attempts validate potential activities against acetylcholinesterase, view developing potent insecticides unique treatment

Language: Английский

Citations

1
Identification of Ajuga Iva Extracts as Potential Candidates for Antidysmenorrhea Targeting Human COX2 and PGE2S‐1 through In Vitro and In Silico Drug Repurposing Approach DOI
Farah Djelti,

A. Adda Berkane,

Hanan M. Alharbi

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(21)

Published: June 3, 2024

Abstract Ajuga Iva , renowned in ethnomedicine, possesses various pharmacological properties, attributed to its diverse phytochemical profile. Despite therapeutic potential, little research has examined the efficacy of treatment dysmenorrhea, a prevalent inflammatory disorder that affects significant number adult women around world, This study aims explore anti‐inflammatory properties context treating dysmenorrhea through combined vitro and silico drug repurposing approach. In assays evaluated plant extracts, revealing activity inhibiting protein denaturation heat‐induced haemolysis. Molecular docking studies identified potential bioactive phytochemicals, including Apigenin, Luteolin, Naringenin, Quercetin, interacting with COX‐2 PGES‐1, key enzymes dysmenorrhea‐associated pathways. dynamics simulations supported these interactions. methanolic extract exhibited activity, as shown by ability inhibit 80.68% at 1000 (μg/m) heat induced haemolysis 83.41% 2000 (μg/m). phytochemicals showed promising interactions suggesting their role plant's mechanism. underscores activities PGE2S‐1, offering valuable insights for future applications.

Language: Английский

Citations

0
Noninvasive Ultra Low Intensity Light Photodynamic Treatment of Glioblastoma with Drug Augmentation: LoGlo PDT Regimen DOI Creative Commons
Richard E. Kast,

Anton Kast,

Jürgen Arnhold

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1164 - 1164

Published: Nov. 21, 2024

This paper presents the basis for LoGlo PDT, a new treatment glioblastoma. Glioblastoma is currently treated with maximal safe resection, temozolomide, and ionizing irradiation. Mortality in 2024 remains over 80% within several years from diagnosis. Oral 5-aminolevulinic acid (5-ALA) an FDA/EMA approved drug that selectively taken up by malignant cells, including In photodynamic of glioblastoma, intense intraoperative light causes glioblastoma tissue has 5-ALA to generate cytotoxic reactive oxygen species. The requirement flux restricted single one-hour session. We analyze here published data showing external light, illuminating entire intact scalp, can attain low μW/cm2 cm into brain would be sufficient mediate if are delivered continuously 24 h. At core PDT regimen dataset that, given fluence, as duration delivery goes down, intensity (flux) must go achieve same cell cytotoxicity weaker (lower flux) longer time. Thus, repetitive, noninvasive using source may possible. cellular physiology show three non-oncology drugs, ciprofloxacin, deferiprone, telmisartan, repurposed increase energy capture after 5-ALA, thereby increasing treatment’s cytotoxicity. approach uses both augmentation prolonged ultra-low transcranial

Language: Английский

Citations

0