Impact of QazVac vaccination on clinical manifestations and immune responses in post—COVID syndrome: a cross-sectional study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Introduction Post-COVID syndrome, also known as long COVID, has emerged a major public health concern, affecting substantial proportion of individuals recovering from SARS-CoV-2 infection. This condition is characterized by persistent symptoms lasting at least 2 months after acute infection, significantly impacting quality life and increasing healthcare burdens. In Kazakhstan, the recognition post- COVID syndrome in national clinical protocols highlights need for effective prevention management strategies. Vaccination been suggested key intervention to reduce severity prevalence symptoms, yet data on its effectiveness, particularly domestic QazVac vaccine, remain limited. The aim this study investigate impact vaccination with vaccine features humoral cellular immunity patients post-COVID conditions identify leading variants course. Methods We analyzed 90 vaccinated 217 non-vaccinated patients, examining sex, age, smoking status, BMI, comorbidities, manifestations. Results There were no significant differences between groups regard status. However, characteristics subjects indicated that was correlated lower diabetes mellitus (2.2% vs. 11.1%, p = 0.011) cardiovascular diseases (0.0% 10.1%, 0.047), higher hypertension among subjects. With presented decreased frequency neurological (51.1% 74.2%, 0.001), gastrointestinal (4.4% 15.2%, 0.008), respiratory (21.1% 36.4%, 0.009), rheumatological (26.7% 38.7%, 0.044), kidney 9.7%, 0.024). contrast, unvaccinated participants had more memory loss (49.8% 22.2%, < depression (31.3% 6.7%, joint pain (33.2% 14.4%, other psychopathological symptoms. Discussion A sharp decrease neurological, gastrointestinal, respiratory, recorded advocating protective role against COVID-19 sequelae. These findings highlight potential mitigate burden complications across various organ systems.

Language: Английский

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The Association Between the Ct Value of SARS-CoV-2 and the Risk of Death from COVID-19 in Amazonas, Peru, During the Circulation of the Lambda, Gamma, and Delta Variants

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 558 - 558

Published: April 12, 2025

This study aimed to assess the association between cycle threshold (Ct) values of SARS-CoV-2 and risk death from COVID-19 in adult patients Amazonas region Peru during circulation Lambda, Gamma, Delta variants. The population included both hospitalized outpatient patients, symptomatic asymptomatic, August 2020 2021. standardized Ct ORF1ab gene were categorized into low high groups based on median value (28.4). Mortality data within 60 days obtained Peruvian epidemiological surveillance system (Notiweb). was estimated using Cox regression, adjusting for relevant predictors potential confounding variables. Among no significant difference observed those with (adjusted hazard ratio [aHR] = 1.61; 95% confidence interval [CI], 0.97–2.67; p 0.067). However, had a significantly higher compared (aHR 1.82; CI, 1.06–3.12; 0.030). persisted after age, sex, occupational group, symptom duration, comorbidities, epidemic dynamics. In conclusion, while (both outpatient) are not associated 60-day mortality risk, is linked an increased patients.

Language: Английский

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Relationship between acute SARS-CoV-2 viral clearance with Long COVID Symptoms: a cohort study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

Abstract Introduction The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. Methods A total 7361 asymptomatic community-dwelling people enrolled in Test Us at Home parent study October 2021 February 2022. Participants self-collected anterior nasal swabs for RT-PCR testing every 24-48 hours 10-14 days, regardless symptom or status. who had no history COVID-19 enrollment were subsequently found to have ≥1 positive test recontacted August 2023 asked whether they experienced COVID, defined as new symptoms lasting 3 months longer following infection. Participant’s cycle threshold values converted into loads, slopes clearance modeled using post-nadir loads. Using a log binomial model with exposure, we calculated relative risk developing 1-2 symptoms, 3-4 5+ adjusting age, number variant. Adjusted (aRR) individual based on was also calculated. Results 172 participants eligible analyses, 59 (34.3%) reported experiencing COVID. increased by 2.44 times (aRR: 2.44; 95% CI: 0.88-6.82) 4.97 4.97; 1.90-13.0) per load slope-unit increase, respectively. developed significantly from peak disease than those never (8.65 [95% 8.28-9.01] vs. 10.0 9.25-10.8]). slope positively associated fatigue 2.86; 1.22-6.69), brain fog 4.94; 2.21-11.0), shortness breath 5.05; 1.24-20.6), gastrointestinal 5.46; 1.54-19.3). Discussion We observed that time RNA an Further, slower rates greater These findings suggest early viral-host are mechanistically important subsequent

Language: Английский

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Infectious Disease as a Modifiable Risk Factor for Dementia: A Narrative Review

Pathogens, Journal Year: 2024, Volume and Issue: 13(11), P. 974 - 974

Published: Nov. 7, 2024

This narrative review examines infectious diseases as modifiable risk factors for dementia, particularly in the context of an aging global population. As prevalence Alzheimer's disease and related dementias is expected to rise, prevention has become increasingly important due limited efficacy current treatments. Emerging evidence links specific increased dementia risk, possibly through mechanisms like neuroinflammation disruption normal cell function. Here, we findings on how viral bacterial infections contribute explore potentially preventive measures, including vaccinations antiviral Studies indicate that against influenza, herpes zoster, hepatitis, well treatments targeting human herpesvirus, could reduce incidence dementia. Additionally, non-pharmaceutical interventions during pandemics long-term care settings are highlighted effective strategies reducing spread diseases, lowering risk. Putative underlying protective effects these suggest systemic inflammation may be their efficacy. While currently available suggests at best association between some this emphasizes need incorporate into broader public health mitigate growing burden Further research required measures across diverse populations deepen our understanding biological involved.

Language: Английский

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Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104924 - 104924

Published: Dec. 18, 2023

BackgroundCOVID-19 vaccines used in humans are highly effective limiting disease and death caused by the SARS-CoV-2 virus, yet improved that provide greater protection at mucosal surfaces, which could reduce break-through infections subsequent transmission, still needed.MethodsHere we tested an intranasal (I.N.) vaccination with receptor binding domain of Spike antigen (S-RBD) combination adjuvant mastoparan-7 compared sub-cutaneous (S.C.) route, adjuvanted either M7 or gold-standard adjuvant, alum, mice, for immunological read-outs. The same formulation delivered I.N. S.C. was hamsters to assess efficacy.FindingsI.N. systemic T cell responses equivalent dose phenotypes induced vaccine administration included enhanced polyfunctionality (combined IFN-γ TNF expression) numbers central memory (TCM) cells. These were cell-intrinsic be recalled lungs and/or brachial LNs upon challenge after adoptive transfer naïve recipients. Furthermore, antibody similarly neutralising parental strain S-RBD its ACE2 receptor, but showed cross-neutralising capacity against multiple variants concern (VOC), vaccination. provided significant from lung pathology unvaccinated animals homologous heterologous strains a hamster model.InterpretationThese results highlight role nasal imprinting immune profile associated long-term retention diversified responses, applied improve COVID-19 other infectious diseases.FundingThis study funded Duke-NUS Medical School, Singapore Ministry Education, National Research Council DBT-BIRAC Grant.

Language: Английский

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Relationship Between Acute Severe Acute Respiratory Syndrome Coronavirus 2 Viral Clearance and Long Coronavirus 2019 (Long COVID) Symptoms: A Cohort Study

Clinical Infectious Diseases, Journal Year: 2024, Volume and Issue: 80(1), P. 82 - 90

Published: Dec. 18, 2024

The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral dynamics during infection and the development of long disease 2019 (COVID-19), or "long COVID," is largely unknown. Between October 2021 February 2022, 7361 people not known to have COVID-19 self-collected nasal swab samples for SARS-CoV-2 reverse-transcription polymerase chain reaction testing every 24-48 hours 10-14 days. Participants whose first was detected were surveyed COVID in August 2023. Their slopes clearance modeled using linear mixed effects models with random intercepts, relative risk (RR) based on calculated a log binomial model, adjusted age, symptoms, variant. Sex-based interaction terms also evaluated significance. A total 172 participants eligible analyses, 59 (34.3%) reported COVID. 3-4 symptoms (adjusted RR, 2.44 [95% confidence interval, .88-6.82]) ≥5 (4.97 [1.90-13.0]) increased each unit increase slope clearance. While probability slowed among women, same observed men (interaction term: P = .02). Acute abdominal pain 5.41 2.44-12.0]), nausea (3.01 [1.31-6.89]), body aches (2.58 [1.26-5.30]) most strongly associated We that slower rates more . Early viral-host appear be mechanistically linked

Language: Английский

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Manifestaciones orales del COVID-19 en Paraguay: resultados de una encuesta en línea.

Medicina Clínica y Social, Journal Year: 2024, Volume and Issue: 8(1), P. 91 - 96

Published: Jan. 9, 2024

Introducción: Estudios previos han reportado que pacientes infectados con el virus del COVID-19, podrían manifestar sintomatologías a nivel de la cavidad oral. Objetivo: Evaluar frecuencia manifestaciones orales asociadas COVID-19 en un segmento población paraguaya y determinar cuáles son las más prevalentes. Metodología: Estudio descriptivo corte transversal. Fue realizada una encuesta electrónica enero marzo 2022. Los datos fueron presentados como frecuencias porcentajes analizados mediante prueba chi-cuadrado. El análisis estadístico se realizó software R versión 4.0.3. Resultados: La muestra estuvo compuesta por 478 personas. 79,50 % correspondió al sexo femenino 45,19 tenía entre 25 34 años. 65,48 informó haber experimentado menos 1 síntoma o signo oral durante curso COVID-19. pérdida sensación sabores amargos, seguida alteración sabor los alimentos percepción dulce, síntomas comunes. Se encontró proporción significativamente mayor rango 18-24 años (?²; p= 0,003). Entre personas desarrollaron forma moderada severa hubo número 0,044). Discusión: identificó alta casos moderados severos destacándose trastornos gusto predominantes. individuos jóvenes afectados.

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Significance of weather condition, human mobility, and vaccination on global COVID-19 transmission

Spatial and Spatio-temporal Epidemiology, Journal Year: 2024, Volume and Issue: 48, P. 100635 - 100635

Published: Jan. 21, 2024

Language: Английский

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Epidemiological and clinical characteristics of long COVID-19 among Iranians: A community-based study in southern Iran

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 26, 2024

Abstract Background The study aimed to evaluate the prevalence and pattern of long COVID-19 (LC) symptoms among individuals who had contracted COVID-19, calculate incidence LC, provide insights into risk factors associated with developing LC in this population. Methods This population-based cross-sectional survey was conducted Fars province 2023. Adult participants a history were recruited using cluster random sampling method, alongside control group similar characteristics through same methodology. Data collected in-person interviews two researcher-developed data collection forms focused on demographic clinical information. Results A total 2010 participants, comprising 1561 (77.7%) 449 (22.3%) without previous included. Among those history, experiencing any 93.7% (95% CI 92.3%-94.8%) during disease acute phase 36.4% 34.0%-38.8%) after recovery. specifically related calculated by comparing symptom rates between found be 13%. Factors such as older age, hospitalization for presence cardiovascular disease, use steroids/chemotherapy symptoms. Conclusions Our investigation sheds light long-term aspects demonstrating significant diverse manifestations. It also underscores importance establishing standardized criteria groups research address challenges heterogeneity potential overestimation

Language: Английский

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EXPRESS: Vaccination significantly reduced the length of SARS-CoV-2 viral clearance: a story from international healthcare workers

Journal of Investigative Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

To investigate the impact of vaccines on sociodemographic characteristics, clinical profiles, and outcomes SARS-CoV-2 infection among healthcare workers in South China during period Omicron variant dominance, a retrospective, analytical cross-sectional study was conducted. The findings revealed that while full vaccination could not prevent efficiently (26.51% uninfected vs 14.29% between vaccinated unvaccinated participants, p = 0.506), it did substantially reduce length viral clearance significantly (p < 0.05), potentially facilitating quicker patient recovery. Unvaccination found to be an independent risk factor for slow when linear regression analysis model used (Coefficient: −3.516; 95% CI: −6.425 −0.607; 0.020). Therefore, all eligible individuals should fully get prepared potential wave epidemic future.

Language: Английский

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