What Is New in Metabolic Dysfunction-Associated Steatotic Liver Disease in Lean Individuals: From Bench to Bedside

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(1), P. 278 - 278

Published: Jan. 3, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects more than 30% of the world’s adult population. While it is associated with obesity and metabolic syndrome, emerging evidence has shown that a substantial number MASLD patients have normal body mass index (“lean individuals MASLD”). In this article, we provide an overview definition, epidemiology, pathogenesis, clinical outcomes lean updates on current management.

Language: Английский

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Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

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Deciphering the molecular pathways of saroglitazar: A dual PPAR α/γ agonist for managing metabolic NAFLD

Metabolism, Journal Year: 2024, Volume and Issue: 155, P. 155912 - 155912

Published: April 11, 2024

Language: Английский

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Metabolic dysfunction associated steatotic liver disease in lean patients. Diagnostic and treatment challenges

Experimental and Clinical Gastroenterology, Journal Year: 2025, Volume and Issue: 9, P. 96 - 109

Published: March 6, 2025

Relevance. Metabolic-associated steatotic liver disease (MASLD) became the first pathology among all diseases with a tendency for further increase in incidence. Patients MASLD and normal weight are special cohort that is difficult to diagnose treat. The purpose: analyze literature about pathogenesis, prognosis of management lean patients MASLD. Materials methods. search devoted NAFLD or was conducted PubMed Google Scholar databases, these articles included adult body mass index less than 25 kg/m2 general population 23 Asian population. Discussion. observed mainly individuals obesity and/or type 2 diabetes mellitus, but 7%-20% have weight. This specific phenotype complex pathogenesis including visceral obesity, sarcopenia, genetic polymorphism, altered microbiota profile behavioral factors. Lean high prevalence metabolic disorders (arterial hypertension, dyslipidemia, mellitus) increased mortality from cardiovascular diseases, causes, compared healthy people. They can develop same spectrum damage (steatohepatitis, fibrosis, cirrhosis) as obesity. article describes diagnostic approaches people, requiring exclusion alternative causes steatosis, well risk groups identification. treatment challenges lack effective pharmacological therapy, necessity factors lifestyle modification. Conclusion. obtained data do not allow us consider benign disease. In this cohort, it necessary stage screen cardiometabolic early.

Language: Английский

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Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6420 - 6420

Published: June 11, 2024

Leptin regulates lipid metabolism, maximizing insulin sensitivity; however, peripheral leptin resistance is not fully understood, and its contribution to metabolic dysfunction-associated steatotic liver disease (MASLD) unclear. This study evaluated the of axis MASLD in humans. Forty-three participants, mostly female (86.04%), who underwent cholecystectomy were biopsied. Of 24 healthy controls, 8 had MASLD, 11 steatohepatitis (MASH). Clinical biochemical data gene expression leptin, receptor (LEPR), suppressor cytokine signaling 3 (SOCS3), sterol regulatory element-binding transcription factor 1 (SREBF1), stearoyl-CoA desaturase-1 (SCD1), patatin-like phospholipase domain-containing protein 2 (PNPLA2), determined from adipose tissue. Higher serum LEPR levels omental tissue (OAT) with MASH found. In liver, was positively correlated tissue, SOCS3 SREBF1-SCD1. OAT, transaminase enzymes (p < 0.05 for all. conclusion, we evidenced correlation between OAT–liver crosstalk complications

Language: Английский

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Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 431 - 462

Published: Jan. 1, 2024

Language: Английский

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Proteome profiling identifies circulating biomarkers associated with hepatic steatosis in subjects with Prader-Willi syndrome

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 15, 2023

Introduction Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by loss of expression paternal chromosome 15q11.2-q13 genes. Individuals with PWS exhibit unique physical, endocrine, and metabolic traits associated severe obesity. Identifying liver steatosis in challenging, despite its lower prevalence compared to non-syndromic Reliable biomarkers are crucial for the early detection management this condition complex profile cardiovascular risks PWS. Methods Circulating proteome profiling was conducted 29 individuals (15 steatosis, 14 without) using Olink Target 96 metabolism cardiometabolic panels. Correlation analysis performed identify association between protein biomarkes clinical variables, while gene enrichment pathways linked deregulated proteins. Receiver operating characteristic (ROC) curves assessed discriminatory power circulating logistic regression model evaluated potential combination biomarkers. Results CDH2, CTSO, QDPR, CANT1, ALDH1A1, TYMP, ADGRE, KYAT1, MCFD, SEMA3F, THOP1, TXND5, SSC4D, FBP1, CES1 exhibited significant differential progressive increase from grade 1 3. CES1, QDPR showed predominant expression. The model, -34.19 + 0.85 * QDPR*QDPR 0.75 CANT1*TYMP - 0.46 THOP1*ALDH1A, achieved an AUC 0.93 (95% CI: 0.63-0.99), sensitivity 93% specificity 80% detecting These strong correlations among themselves were involved interconnected network 62 nodes, related seven pathways. They also significantly cholesterol, LDL, triglycerides, transaminases, HbA1c, FLI, APRI, HOMA, negative correlation HDL levels. Conclusion identified study offer improved patient stratification personalized therapeutic protocols.

Language: Английский

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PNPLA3 and SAMM50 variants are associated with lean nonalcoholic fatty liver disease in Asian population

Annals of Hepatology, Journal Year: 2024, Volume and Issue: unknown, P. 101761 - 101761

Published: Dec. 1, 2024

Lean adults with nonalcoholic fatty liver disease (NAFLD) have a higher risk of metabolic syndrome than lean controls. The study aimed to investigate the clinical and genetic features NAFLD which remain unclear in Asian populations.

Language: Английский

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Dynamics of blood adipokine levels and their ratios in assisted reproductive technology programs depending on the clinical pregnancy onset

Journal of obstetrics and women s diseases, Journal Year: 2024, Volume and Issue: 73(5), P. 84 - 95

Published: Dec. 4, 2024

BACKGROUND: The adipokines leptin, adiponectin, and ghrelin are expressed not only in adipose tissue but also the hypothalamic-pituitary-gonadal axis organs uterus. They regulate gonadotropin-releasing hormone gonadotropin secretion, steroidogenesis, folliculogenesis, implantation, serve as promising markers of assisted reproductive technology program outcomes. AIM: aim this study was to evaluate dynamics blood adipokine levels their ratios during controlled ovarian hyperstimulation programs depending on onset clinical pregnancy. MATERIALS AND METHODS: This involved 51 patients undergoing infertility treatment using a short protocol with antagonists. Depending pregnancy, two groups were formed: non-pregnant (group 1, n = 22) pregnant 2, 29). Blood assessed enzyme immunoassay at three points: start-up, day oocyte pick-up, embryo transfer. RESULTS: On group 1 had higher leptin (5.47 ± 1.92 vs. 3.76 0.75 ng/ml; p 0.0004), leptin/adiponectin (11.45 4.50 4.73 1.08; 0.001), leptin/ghrelin (0.43 0.17 0.24 0.07; 0.001). transfer, (6.37 2.13 3.29 1.21 0.001) adiponectin (0.75 0.22 0.60 0.09 well (9.06 3.73 5.59 2.32; (0.48 0.15 0.20 adiponectin/ghrelin (0.06 0.02 0.04 0.01; CONCLUSIONS: data obtained indicate that change protocols pregnancy can be used predict its onset.

Language: Английский

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Systematic review and meta-analyses of adipokine levels in hypothyroidism: a role for retinol-binding protein 4

Expert Review of Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Background Hypothyroidism (HT) is associated with numerous well-characterized comorbidities and established biomarkers for subclinical atherosclerosis which may lead to an elevated risk of cardiovascular disease; however, the precise molecular mechanism underlying these pathological features remains elusive. Increased levels adipokines have adverse effects on multiple atherosclerotic factors in HT. Different studies evaluated association between HT conflicting results.

Language: Английский

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