Dual level dengue diagnosis using lightweight multilayer perceptron with XAI in fog computing environment and rule based inference DOI Creative Commons

R. Deepika,

Pacheco Antonio L. S.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 13, 2025

Language: Английский

Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging DOI
Saurabh Gupta, Muhammad Afzal, Neetu Agrawal

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 26, 2025

Language: Английский

Citations

1
Translational paradigm in nanodiagnostics applications of functionalized zinc oxide nanoforms interface for pathogenic virus diagnostics DOI

Abha Gupta,

Apoorv Kirti,

Rabindranath Sahu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 509, P. 161260 - 161260

Published: March 5, 2025

Language: Английский

Citations

1
The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials DOI Creative Commons
Chen Zhang,

Shu Xu,

Chuanzheng Yin

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 29, 2025

Breast cancer remains the most frequently diagnosed globally, exerting a profound impact on women's health and healthcare systems. Central to its pathogenesis therapeutic resistance are breast stem cells (BCSCs), which possess unique properties such as self-renewal, differentiation, conventional therapies, contributing tumor initiation, metastasis, recurrence. This comprehensive review elucidates pivotal role of mechanistic target rapamycin (mTOR) pathway in regulating BCSCs implications for progression treatment resistance. We explore cellular mechanisms by mTOR influences metabolism, autophagy, ferroptosis BCSCs, highlighting contribution epithelial-to-mesenchymal transition (EMT), metabolic reprogramming, survival under stress. On molecular level, interacts with key signaling pathways including PI3K/Akt, Notch, IGF-1R, AMPK, TGF-β, well regulatory proteins non-coding RNAs, orchestrating complex network that sustains BCSC mediates chemoresistance radioresistance. The further examines various strategies targeting encompassing selective PI3K/Akt/mTOR inhibitors, monoclonal antibodies, natural products, innovative approaches nanoparticle-mediated drug delivery. Clinical trials investigating inhibitors like sirolimus combination therapies agents everolimus trastuzumab discussed, underscoring their potential eradicating improving patient outcomes. Additionally, compounds repurposed drugs offer promising adjunctive modulating activity BCSC-specific vulnerabilities. In conclusion, presents viable avenue enhancing efficacy effectively eliminating reducing recurrence, overall survival. Continued research clinical validation mTOR-targeted essential translate these insights into effective interventions, ultimately advancing personalized management outcomes patients.

Language: Английский

Citations

1
GRP78: A New Promising Candidate in Colorectal Cancer Pathogenesis and Therapy DOI
Song Wang, Neda Rahimian,

Aysa Hasanzade Bashkandi

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177308 - 177308

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeted Inhibition of NPR3/MAPK Pathway Enhances Dental Pulp Stem Cell Multipotency: Mechanistic Validation Based on Ligustrazine (TMP) DOI
Heyang Cui, Y Zhang,

Huiling Liang

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 446(1), P. 114479 - 114479

Published: Feb. 20, 2025

Language: Английский

Citations

0
Integration of Focused Ultrasound and Dynamic Imaging Control System for Targeted Neuro-modulation DOI Creative Commons

K. M. Karthick Raghunath,

Surbhi Bhatia Khan,

T R Mahesh

et al.

Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: unknown, P. 110391 - 110391

Published: Feb. 1, 2025

Language: Английский

Citations

0
β-elemene: A promising natural compound in lung cancer therapy DOI
Jiguang Bao, Zhiliang Li, D Zhang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177399 - 177399

Published: March 1, 2025

Language: Английский

Citations

0
Role of the circRNA/miRNA/mRNA axis in Renal Cell Carcinoma: from gene regulation to metabolism and immunity DOI Creative Commons

Zhengjun Xu,

Yurong Dong,

Kun Cui

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112183 - 112183

Published: March 12, 2025

Renal cell carcinoma (RCC), particularly clear RCC (ccRCC), has seen rising incidence and mortality rates. Early detection remains difficult due to nonspecific symptoms, often leading diagnoses at advanced stages unfavorable prognoses. Current treatments, including surgery, targeted therapies, immunotherapies, face limitations such as adverse reactions, drug resistance, immune evasion. This review discusses the role of circular RNAs (circRNAs) their involvement in circRNA/miRNA/mRNA axis during progression. As competitive endogenous (ceRNAs), circRNAs regulate gene expression cellular processes, proliferation, metastasis, apoptosis, resistance. Furthermore, we explore impact on tumor metabolic reprogramming influence microenvironment. We also summarize clinical prospects, challenges, future directions this field. A comprehensive understanding these complex interactions may provide new insights into diagnosis treatment RCC, ultimately overcoming existing challenges improving patient outcomes.

Language: Английский

Citations

0
Lacticaseibacillus casei IDCC 3451 alleviates cognitive and behavioral functions by reshaping the gut microbiome and regulating intestinal barrier integrity in chronic stress animal models DOI Creative Commons
Anna Kang,

Ju Young Eor,

Junbeom Lee

et al.

Current Research in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101051 - 101051

Published: April 1, 2025

Lacticaseibacillus casei IDCC 3451 (3451) was evaluated for its effects on the gut-brain axis using Caenorhabditis elegans (C. elegans) and mouse models of stress inflammation. In C. elegans, extended lifespans by 25 %, improved motility, chemotaxis, enhanced survival under pathogen challenge, reduced amyloid beta accumulation 42 %. Transcriptomic profiling revealed upregulation genes involved in neurotransmitter signaling serine/threonine pathways. unpredictable chronic mild (UCMS) model, administration increased time spent center open field 65 % immobility forced swim test 32 indicating anxiolytic antidepressant effects. Serum levels aspartate aminotransferase (AST) gamma-glutamyl transferase (GGT) were decreased 18 24 respectively. Additionally, restored expressions 5HT1AR, GABAR, tight junction proteins, including ZO-1 Claudin1. Metabolomic analysis showed glycine palmitic acid levels, associated with an abundance Ruminococcus Akkermansia. dextran sulfate sodium (DSS)-induced colitis disease activity index 36 colon histology, goblet cell preservation, upregulated IL-10 expression. Threonine also correlated a higher Coprococcus. These findings demonstrate that behavioral intestinal outcomes through coordinated modulation host signaling, metabolite production, gut microbial composition, highlighting therapeutic potential managing IBD neurobehavioral disorders.

Language: Английский

Citations

0
The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target DOI Creative Commons

Min Cheol Hong,

Xu‐Feng Huang, Huiming Zhu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Circular RNA (circRNA) is a new type of non-coding that has gained significant attention in recent years, especially tuberculosis research. Tuberculosis poses major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate research breakthroughs. The role circRNA mycobacterium infection being gradually revealed, highlighting its importance regulating gene expression, immune response, inflammation. Additionally, researchers are interested because potential for early diagnosis as biomarker. This article systematically analyzes existing literature to provide insights into personalized treatment. We also emphasize the need future enhance application prevention control.

Language: Английский

Citations

0