Unveiling lactylation modification: A new hope for cancer treatment
Yuxiang Luo,
No information about this author
Ning Zhang,
No information about this author
Jiarong Ye
No information about this author
et al.
Biomedicine & Pharmacotherapy,
Journal Year:
2025,
Volume and Issue:
184, P. 117934 - 117934
Published: Feb. 21, 2025
Language: Английский
Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications
Chuncha Bao,
No information about this author
Qing Ma,
No information about this author
Xuchao Ying
No information about this author
et al.
EBioMedicine,
Journal Year:
2024,
Volume and Issue:
111, P. 105502 - 105502
Published: Dec. 10, 2024
Language: Английский
The role of lactylation in virology
Virology,
Journal Year:
2025,
Volume and Issue:
605, P. 110466 - 110466
Published: Feb. 25, 2025
Language: Английский
Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation
Shuang Ge,
No information about this author
Bingquan Qiu,
No information about this author
Rong Liu
No information about this author
et al.
Biochemical Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 116879 - 116879
Published: March 1, 2025
Language: Английский
Immunometabolism of Innate Immune Cells in Gastrointestinal Cancer
Cancers,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1467 - 1467
Published: April 27, 2025
Cancer
cells
are
often
described
as
voracious
consumers
of
nutrients,
with
glucose
frequently
cited
a
key
energy
source;
however,
their
metabolic
plasticity
allows
them
to
adapt
and
utilize
various
substrates,
including
lipids
amino
acids,
sustain
growth
survival.
However,
the
demands
immune
within
tumor
microenvironment
(TME)
less
commonly
discussed
despite
critical
role
in
shaping
response.
In
this
review,
we
explored
intricate
interplay
between
immunometabolism
innate
immunity
gastrointestinal
cancers.
We
focused
on
how
pathways,
glycolysis,
fatty
acid
oxidation,
metabolism,
drive
immunosuppressive
functions
myeloid-derived
suppressor
(MDSCs)
tumor-associated
neutrophils
(TANs),
macrophages
(TAMs)
lymphocyte
subsets
such
NK
cells.
These
contribute
hostile
landscape,
supporting
evasion
from
surveillance
phenomenon
tumor-derived
immunosuppression.
Additionally,
investigated
influence
dietary
interventions
reprogramming
these
cells,
highlighting
nutrition
can
modulate
TME.
Finally,
emerging
therapeutic
strategies
that
target
vulnerabilities
MDSCs,
TANs,
monocytes,
offering
novel
avenue
for
enhancing
antitumor
immunity.
By
dissecting
mechanisms,
aim
provide
insights
into
pathways
be
harnessed
improve
cancer
treatment
outcomes.
This
review
underscores
importance
understanding
not
only
driver
suppression
but
also
potential
cancer.
Language: Английский
The roles of lactate and the interplay with m6A modification in diseases
Fajuan Tang,
No information about this author
Dongqiong Xiao,
No information about this author
Xihong Li
No information about this author
et al.
Cell Biology and Toxicology,
Journal Year:
2024,
Volume and Issue:
40(1)
Published: Dec. 2, 2024
Lactate
exhibits
various
biological
functions,
including
the
mediation
of
histone
and
non-histone
lactylation
to
regulate
gene
transcription,
influencing
activity
T
lymphocytes,
NK
cells,
macrophages
in
immune
suppression,
activating
G
protein-coupled
receptor
81
for
signal
transduction,
serving
as
an
energy
substrate.
The
m6A
modification
represents
most
prevalent
post-transcriptional
epigenetic
alteration.
It
is
regulated
by
m6A-related
regulatory
enzymes
(including
methyltransferases,
demethylases,
recognition
proteins)
that
control
splicing,
stability,
translation
downstream
target
RNAs.
Lactate-mediated
at
H3K18
can
modulate
modifications
enhancing
transcriptional
expression
levels
enzymes.
These
play
a
crucial
role
progression
diseases
such
cancer,
fibrosis
(in
both
liver
lung),
myocardial
ischemia,
cerebral
hemorrhage,
sepsis.
Furthermore,
are
also
subject
lactate.
In
turn,
these
influence
key
glycolytic
pathway
or
modify
lactate
transporter
MCT4
via
alterations
impact
subsequently
affect
processes.
Language: Английский