The roles of lactate and the interplay with m6A modification in diseases DOI Creative Commons

Fajuan Tang,

Dongqiong Xiao, Xihong Li

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Dec. 2, 2024

Lactate exhibits various biological functions, including the mediation of histone and non-histone lactylation to regulate gene transcription, influencing activity T lymphocytes, NK cells, macrophages in immune suppression, activating G protein-coupled receptor 81 for signal transduction, serving as an energy substrate. The m6A modification represents most prevalent post-transcriptional epigenetic alteration. It is regulated by m6A-related regulatory enzymes (including methyltransferases, demethylases, recognition proteins) that control splicing, stability, translation downstream target RNAs. Lactate-mediated at H3K18 can modulate modifications enhancing transcriptional expression levels enzymes. These play a crucial role progression diseases such cancer, fibrosis (in both liver lung), myocardial ischemia, cerebral hemorrhage, sepsis. Furthermore, are also subject lactate. In turn, these influence key glycolytic pathway or modify lactate transporter MCT4 via alterations impact subsequently affect processes.

Language: Английский

Unveiling lactylation modification: A new hope for cancer treatment DOI Open Access

Yuxiang Luo,

Ning Zhang, Jiarong Ye

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117934 - 117934

Published: Feb. 21, 2025

Language: Английский

Citations

1
Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications DOI Creative Commons

Chuncha Bao,

Qing Ma, Xuchao Ying

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 111, P. 105502 - 105502

Published: Dec. 10, 2024

Language: Английский

Citations

5
The role of lactylation in virology DOI
Sirui Wang, Leiliang Zhang

Virology, Journal Year: 2025, Volume and Issue: 605, P. 110466 - 110466

Published: Feb. 25, 2025

Language: Английский

Citations

0
Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation DOI Creative Commons
Shuang Ge,

Bingquan Qiu,

Rong Liu

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116879 - 116879

Published: March 1, 2025

Language: Английский

Citations

0
Immunometabolism of Innate Immune Cells in Gastrointestinal Cancer DOI Open Access
Izabela Siemińska, Marzena Lenart

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1467 - 1467

Published: April 27, 2025

Cancer cells are often described as voracious consumers of nutrients, with glucose frequently cited a key energy source; however, their metabolic plasticity allows them to adapt and utilize various substrates, including lipids amino acids, sustain growth survival. However, the demands immune within tumor microenvironment (TME) less commonly discussed despite critical role in shaping response. In this review, we explored intricate interplay between immunometabolism innate immunity gastrointestinal cancers. We focused on how pathways, glycolysis, fatty acid oxidation, metabolism, drive immunosuppressive functions myeloid-derived suppressor (MDSCs) tumor-associated neutrophils (TANs), macrophages (TAMs) lymphocyte subsets such NK cells. These contribute hostile landscape, supporting evasion from surveillance phenomenon tumor-derived immunosuppression. Additionally, investigated influence dietary interventions reprogramming these cells, highlighting nutrition can modulate TME. Finally, emerging therapeutic strategies that target vulnerabilities MDSCs, TANs, monocytes, offering novel avenue for enhancing antitumor immunity. By dissecting mechanisms, aim provide insights into pathways be harnessed improve cancer treatment outcomes. This review underscores importance understanding not only driver suppression but also potential cancer.

Language: Английский

Citations

0
The roles of lactate and the interplay with m6A modification in diseases DOI Creative Commons

Fajuan Tang,

Dongqiong Xiao, Xihong Li

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Dec. 2, 2024

Lactate exhibits various biological functions, including the mediation of histone and non-histone lactylation to regulate gene transcription, influencing activity T lymphocytes, NK cells, macrophages in immune suppression, activating G protein-coupled receptor 81 for signal transduction, serving as an energy substrate. The m6A modification represents most prevalent post-transcriptional epigenetic alteration. It is regulated by m6A-related regulatory enzymes (including methyltransferases, demethylases, recognition proteins) that control splicing, stability, translation downstream target RNAs. Lactate-mediated at H3K18 can modulate modifications enhancing transcriptional expression levels enzymes. These play a crucial role progression diseases such cancer, fibrosis (in both liver lung), myocardial ischemia, cerebral hemorrhage, sepsis. Furthermore, are also subject lactate. In turn, these influence key glycolytic pathway or modify lactate transporter MCT4 via alterations impact subsequently affect processes.

Language: Английский

Citations

0