The Role of Lifestyle Interventions in PCOS Management: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 310 - 310

Published: Jan. 16, 2025

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders among reproductive-aged women. It characterized by hyperandrogenism, anovulation, and polycystic ovaries. Lifestyle changes are suggested as first-line interventions in managing PCOS. This systematic review aims to assess scientific evidence regarding role lifestyle modifications (dietary changes, physical activity, behavioral changes) improving reproductive, anthropometric, metabolic, psychological outcomes women with Dietary such foods low glycemic index scores; caloric restrictions; high-fiber, omega three fatty acid-rich diets; ketogenic Mediterranean antioxidant-rich food; anti-inflammatory diets improve insulin sensitivity hormonal balance Physical like aerobic resistance exercise, enhances sensitivity, helps weight loss, improves metabolic reproductive Further, education modules can also be used awareness, adherence, effectiveness conventional treatment manage mental health issues related Collectively, not only biochemical, hormonal, anthropometric parameters PCOS patients but reduce long-term risks cardiovascular diseases.

Language: Английский

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Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 284 - 284

Published: Jan. 14, 2025

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and requires better treatment. N-acetylcysteine (NAC) known to be beneficial under such conditions owing its antioxidant potential insulin-sensitizing properties. The effect NAC on the outcomes PCOS patients was examined in this meta-analysis. Methods: In accordance with PRISMA standards, meta-analysis included studies compared N-acetylcysteine, metformin, clomiphene citrate, placebo POCS. main indicators were follicular growth, endometrial thickness, hormone level. risk bias evaluated using Cochrane ROB2 tool. Results: Twenty-two (n = 2515) included. associated statistically significant increase progesterone (SMD 0.95, 95% CI: 0.13–1.77, p 0.02) thickness 0.58, 0.10–1.06, other drugs 0.71, 0.48–0.94, < 0.0001). LH levels significantly increased by metformin 0.67, 0.23–1.12, 0.003). However, no differences observed estradiol, SHBG, or FSH levels. Conclusions: had major progesterone, PCOS. Therefore, it may treatment option.

Language: Английский

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A review of antioxidant N-acetylcysteine in addressing polycystic ovary syndrome

Gynecological Endocrinology, Journal Year: 2024, Volume and Issue: 40(1)

Published: July 22, 2024

N-acetylcysteine (NAC), a compound known for its cysteine and glutathione precursor properties, has been used in therapeutic applications many years. Recently, there increasing interest exploring the potential benefits of NAC addressing polycystic ovary syndrome (PCOS). However, exact mechanisms underlying NAC's clinical uses remain not fully understood. This review aims to specifically investigate how offers protection against PCOS. involved an extensive systematic literature, it made use PubMed, Embase, Web Science databases. By analyzing key findings from over 100 research papers, through which produces effects were explored summarized. Most studies suggest that NAC, whether on own or combination with other medications, counteract oxidative stress, utilize anti-inflammatory anti-apoptotic offer managing Moreover, might have influence specific signaling pathways insulin target cells β cells. Diverse biological indicate usefulness as supplementary approach As result, additional is required explore

Language: Английский

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The Effectiveness and Safety of a Nutraceutical Combination in Overweight Patients with Metabolic Syndrome

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 3977 - 3977

Published: Nov. 21, 2024

Background: The aim of the present study was to evaluate effectiveness and safety a nutraceutical combination given insulin-resistant overweight patients with altered lipid profiles. To this end, an observational designed in which 74 individuals (50 females 24 males) underwent period 3 months. Methods: During time, specific containing myo-inositol, glycine, Coprinus comatus, α-lipoic acid, phlorizin, zinc, vitamin B6, chromium picolinate administered. Patients were asked not modify their lifestyles so that no variable might interfere results introduced. Results: After 3-month period, obtained data revealed insulin levels significantly decreased respect baseline, while glucose exhibited trend towards lower concentrations, significant. In addition, HOMA-IR index, body weight, BMI, abdominal circumference values all significantly. Regarding profiles, before after showed statistically significant decreases concentrations total cholesterol, LDL triglyceride, as well small but concomitant increase HDL cholesterol. Conclusions: Thus, on basis these data, it may be stated used ameliorated number metabolic parameters without measurable side effects. efficacy product were, therefore, confirmed our group patients.

Language: Английский

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