Extracellular vesicles as human therapeutics: A scoping review of the literature

Journal of Extracellular Vesicles, Journal Year: 2024, Volume and Issue: 13(5)

Published: May 1, 2024

Abstract Extracellular vesicles (EVs) are released by all cells and contribute to cell‐to‐cell communication. The capacity of EVs target specific efficiently deliver a composite profile functional molecules have led researchers around the world hypothesize their potential as therapeutics. While studies EV treatment in animal models numerous, actual clinical benefit humans has more slowly started be tested. In this scoping review, we searched PubMed other databases up 31 December 2023 and, starting from 13,567 records, selected 40 pertinent published testing therapeutics humans. analysis those shows that they small pilot trials with large heterogeneity terms administration route disease. Moreover, absence placebo control most studies, predominant local application formulations inconsistent dose metric still impede comparison across firm conclusions about safety efficacy. On hand, recording some promising outcomes strongly calls out for well‐designed larger test an alternative approach treat human diseases no or few therapeutic options.

Language: Английский

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EXOSOMES FOR SKIN TREATMENT: THERAPEUTIC AND COSMETIC APPLICATIONS

Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100048 - 100048

Published: Sept. 1, 2024

Language: Английский

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Exosomes in the Real World of Medical Aesthetics: A Review

Aesthetic Plastic Surgery, Journal Year: 2024, Volume and Issue: 48(13), P. 2513 - 2527

Published: Feb. 5, 2024

Language: Английский

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The Role of Exosomes in Medical Dermatology: Literature Review and Update

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

ABSTRACT Background Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that primarily derived from stem cells. The contents exosomes can be incorporated into the tissue in which they introduced, presents unique therapeutic option. Aims have been investigated as treatment for number medical ailments, but literature supporting these indications is inconclusive. In addition, much study on and their uses has recently completed. Thus, this review summarizes efficacy implications different dermatologic conditions. Methods A surrounding use multiple dermatological conditions was conducted. Additionally, we present numerous practical cases patients had treated with exosomes. Results Overall, success treating demonstrated varying literature, preliminary evidence generally positive. patient also showed satisfactory clinical outcomes further studies will necessary to fully characterize ideal modalities application, including formulation, mode distribution, frequency treatment. Conclusions may serve an effective option wound healing, reconstruction skin flaps, radiation dermatitis, acne vulgaris, psoriasis, atopic allergic contact lichen simplex chronicus, vulvar sclerosis, systemic lupus erythematosus, vitiligo although additional needed confirm safety.

Language: Английский

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Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Management of Atopic Dermatitis: A Scoping Review of Therapeutic Opportunities and Challenges

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2673 - 2693

Published: March 1, 2025

Atopic dermatitis (AD) is a global concern marked by inflammation, skin barrier dysfunction, and immune dysregulation. Current treatments primarily address symptoms without offering cure, underscoring the need for innovative therapeutic approaches. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have attracted attention their potential in immunomodulation tissue repair, similar to parent cells. This review provides comprehensive analysis of current landscape MSC-EV research AD management. We identified 12 studies that met our predefined inclusion criteria. thoroughly reviewed both human animal studies, analyzing aspects such as source, isolation, characterization MSC-EVs, well disease models, dosage strategies, efficacy, mechanisms, adverse effects. While this highlights promising therapy AD, it also emphasizes significant challenges, including heterogeneity insufficient reporting. Given area still its early stages, addressing these uncertainties will require collaborative efforts among researchers, regulatory bodies, international societies advance field improve patient outcomes.

Language: Английский

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Mesenchymal stem cells-derived small extracellular vesicles and apoptotic extracellular vesicles for wound healing and skin regeneration: a systematic review and meta-analysis of preclinical studies

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Studies examining the therapeutic potential of Mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) in wound healing and skin regeneration have progressed rapidly. Prior to considering clinical translation, a systematic comprehensive understanding these experimental details overall impact MSC-EVs on is necessary. 83 studies were identified Web Science, Embase, PubMed that satisfied set prespecified inclusion criteria. A random effects meta-analysis was conducted for closure rate, scar width, blood vessel density collagen deposition. Our findings demonstrate clear be developed as therapy both diabetic non-diabetic animal models. Moreover, subgroup analyses demonstrated apoptotic small (ApoSEVs) showed better efficacy than bodies (ApoBDs) (sEVs) outcome deposition, while sEVs displayed ApoEVs revascularization. Among frequently used routes administration, subcutaneous injection greater improvement closure, deposition revascularization compared dressing/covering. easier-access source MSCs, ADSCs best effect rate compared, BMMSCs Additionally, high heterogeneity observed collection conditions, separation methods, storage modifications, treatment dose, administration route, frequency underscores urgent need standardization areas, prior translation. PROSPERO CRD42024499172.

Language: Английский

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Safety assessment of multiple systemic administration of human mesenchymal stem cell-conditioned medium for various chronic diseases

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0322497 - e0322497

Published: May 6, 2025

Conditioned medium (CM) derived from human mesenchymal stem cells (MSCs) has shown potential as a therapeutic agent. However, the safety of its administration in remains largely unexplored. This study evaluated multiple systemic administrations MSC-CM, specifically adipose-derived and umbilical cord-derived 55 patients with various chronic diseases. Symptom assessments blood tests were conducted before after to monitor adverse events measure inflammatory marker C-reactive protein (CRP), respectively. The results demonstrated no serious attributed MSC-CM administration. Although minor observed, their causal relationship remained unclear. Additionally, slightly reduced CRP levels, regardless route (intraarterial, intravenous, or inhalation). significant reduction levels was observed elevated (CRP > 0.3) following These findings suggest that repeated is likely safe may have anti-inflammatory effects.

Language: Английский

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Medicalized Aesthetic Uses of Exosomes and Cell Culture-Conditioned Media: Opening an Advanced Care Era for Biologically Inspired Cutaneous Prejuvenation and Rejuvenation

Cosmetics, Journal Year: 2024, Volume and Issue: 11(5), P. 154 - 154

Published: Sept. 7, 2024

Recent advancements in aesthetic medicine offer innovative cosmetic solutions to enhance patient skin quality and appearance. Advanced treatment options enable practitioners effectively address aging signs, pigmentation imbalance, loss of elasticity ambulatory home-based care regimens. Exosomes (nanoscale cell-derived vesicles) transport a variety biomolecules are pivotal physiological intercellular communication. Importantly, exosomes have recently emerged as key endogenous players tissular regeneration. More broadly (from an active ingredient purity standpoint), exosomes, stem cell secretomes, culture-conditioned media been clinically proven exert multifaceted beneficial topical effects (anti-inflammatory, antioxidant, anti-aging, rejuvenation). Therefore, human, animal, plant-derived or other refined sub-cellular biological fractions gaining substantial interest within the industries. Notably, such approaches thought be among most promising novel contenders for advanced, biologically inspired prejuvenation rejuvenation care. The present narrative review summarizes latest oriented research on media, highlighting their mechanisms action various applications. Furthermore, it explores innovation landscape currently commercially available products global market discusses potential future applications ingredients medical industry.

Language: Английский

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Topical moisturizer with rose stem cell‐derived exosomes (RSCEs) for recalcitrant seborrheic dermatitis: A case report with 6 months of follow‐up

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Abstract Introduction Seborrheic dermatitis (SD) poses significant treatment challenges due to its chronic nature and the side effects associated with long‐term use of conventional therapies like topical corticosteroids. In search for alternative treatments, exosomes, particularly those derived from rose stem cells (RSCEs), offer a promising avenue their potential in managing skin conditions. Objective This case report examines efficacy moisturizer containing RSCEs treating patient refractory SD, aiming provide an pathway. Materials Methods A 40‐year‐old male long‐standing history unresponsive traditional underwent novel regimen. regimen included initial application 2.5 mL followed by maintenance phase involving RSCE‐containing moisturizer. Clinical outcomes were assessed through Patient's Global Assessment (PGA) Investigator's (IGA) scores, along evaluations scaling erythema. Results Remarkable clinical improvement was noted as early 1‐day post‐treatment, reductions redness, scaling, itching. The experienced sustained relief throughout 6‐month follow‐up, recurrence sixth month that less severe than previous flare‐ups. demonstrated not only symptom management but also extending remission periods. Conclusion SD can benefit innovative treatments moisturizer, shown this report. While observed are promising, indicating substantial improvements condition management, larger controlled studies necessary validate therapeutic exosome‐containing moisturizers fully. underscores need treatment, highlighting role exosomes viable option.

Language: Английский

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The therapeutic, diagnostic, and prognostic values of extracellular vesicles (exosomes) in dermatology: A Systematic Review

JAAD reviews., Journal Year: 2024, Volume and Issue: 1, P. 135 - 174

Published: July 14, 2024

The clinical exploration of extracellular vesicles (EVs, also called exosomes) in dermatology has recently grown, including cosmeceuticals. This systematic review aimed to collate existing observations on EVs for either therapeutic intervention or as a diagnostic prognostic tool and critically assess the degree evidence any observed feature. Primary studies that enrolled patients with dermatologic conditions reported role were included. Screening analysis, data extraction, quality assessment performed by 4 investigators. GRADE-CERQual, an adapted approach assessing certainty qualitative sytematic reviews, was utilized determine confidence data. Outcomes included effectiveness EVs' formulations, their safety, potential. Fifty-two reporting from 3066 Methodologic inconsistencies, poor reporting, low numbers reduced certainty. potential utilization studied but have not been validated. are being introduced into practices globally Observational implied some efficacy, regulatory perspective, our knowledge, no EV-based therapeutics approved dermatology. Future trials need be randomized, double-blind, placebo-controlled support approvals, findings supported larger cohorts.

Language: Английский

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