3 Biotech, Journal Year: 2023, Volume and Issue: 13(9)
Published: Aug. 24, 2023
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 129 - 129
Published: Jan. 17, 2025
This study investigates for the first time use of prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles deliver properly an active pharmaceutical ingredient. Curcumin (CCM), a hydrophobic compound classified under BCS (Biopharmaceutics Classification System) class IV, was selected as model drug. Key process parameters, including polymer concentration, type, nozzle size, surfactant levels, were optimized obtain stable narrow size distribution determined by DLS analysis. Particles mean diameter (d50) 316 452 nm, depending on drug-loaded cargo Curcumin-loaded nanoparticles demonstrated high encapsulation efficiency, assessed via HPLC analysis, stability, controlled release profiles. In vitro studies revealed faster lower drug loadings (90% 6 h) compared sustained over 7 days higher-loaded nanoparticles, attributed degradation drug-polymer interactions surface particles, confirmed FTIR analyses. These findings underline potential this scalable biomedical applications, offering versatile platform designing delivery systems tailored characteristics.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 259 - 279
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2024, Volume and Issue: 9(25), P. 27669 - 27679
Published: June 13, 2024
Curcumin has demonstrated promising preclinical antiobesity effects, but its low bioavailability makes it difficult to exert full effect at a suitable dose. The objective of this study was screen curcumin derivatives with enhanced and lipid-lowering activity under the guidance computer-aided drug design (CADD). CAAD used perform virtual assays on assess their pharmacokinetic properties effects pancreatic lipase activity. Subsequently, 19 containing 5 skeletons were synthesized confirm above assay. in vitro inhibition assay employed determine half-maximal inhibitory concentration (IC50) these derivatives. Based CADD analysis inhibition, 2 outperformed both aspects. Microscale thermophoresis (MST) experiments binding equilibrium constants (Kd) aforementioned derivatives, curcumin, positive control lipase. Through screening utilizing chemoinformatics database molecular docking, 6 superior solubility, absorption, compared curcumin. IC50 value for 1,7-bis(4-hydroxyphenyl)heptane-3,5-dione (C4), which displayed most effective effect, 42.83 μM, while 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione (C6) 98.62 μM. On other hand, 142.24 MST experiment results indicated that Kd values C4, C6, 2.91, 18.20, 23.53 respectively. exhibited relatively high degree concordance outcomes yielded by screening. Under CADD, targeted excellent high-efficiency low-cost benefits.
Language: Английский
Citations
3
Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140513 - 140513
Published: July 19, 2024
Language: Английский
Citations
3
Neuropharmacology, Journal Year: 2024, Volume and Issue: 259, P. 110096 - 110096
Published: July 29, 2024
Neurological disorders pose a huge worldwide challenge to the healthcare system, necessitating innovative strategies for targeted drug delivery central nervous system. Alzheimer's disease (AD) is an untreatable neurodegenerative condition characterized by dementia and alterations in patient's physiological mental states. Since ancient times, medicinal plants have been important source of bioactive phytochemicals with immense therapeutic potential. This review investigates new safer alternatives prevention treatment related inevitable side effects associated synthetic compounds. examines how nanotechnology can help enhancing neuroprotective AD. Nevertheless, despite their remarkable properties, these natural products often poor efficacy due low bioavailability, limited solubility imperfect blood brain barrier (BBB) penetration. Nanotechnology produces personalized systems which are necessary solving such problems. In overcoming challenges, might be employed as way forward whereby customized medication would established result. The use nanocarriers design application highlighted this review, indicate potential revolutionizing delivery. We also explore complications possibilities using supply nutraceuticals improve patients' standard living, preclinical well clinical investigations displaying that techniques effective mitigating diseases. order fight diseases health, scientists doctors employ its possible interventions.
Language: Английский
Citations
3
Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1384 - 1384
Published: Aug. 24, 2024
Nanomedicine is a newer, promising approach to promote neuroprotection, neuroregeneration, and modulation of the blood–brain barrier. This review includes integration various nanomaterials in neurological disorders. In addition, gelatin-based hydrogels, which have huge potential due biocompatibility, maintenance porosity, enhanced neural process outgrowth, are reviewed. Chemical modification these especially with guanidine moieties, has shown improved neuron viability underscores tailored biomaterial design applications. further discusses strategies modulate barrier—a factor critically associated effective delivery drugs central nervous system. These advances bring supportive solutions solving conditions innovative therapies for their treatment. Nanomedicine, as applied neuroscience, presents significant leap forward new therapeutic that might help raise treatment management disorders much better levels. Our aim was summarize current state-of-knowledge this field.
Language: Английский
Citations
3
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106077 - 106077
Published: Aug. 23, 2024
Language: Английский
Citations
2
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 335, P. 103333 - 103333
Published: Nov. 4, 2024
Language: Английский
Citations
2
Food Reviews International, Journal Year: 2023, Volume and Issue: 40(7), P. 1913 - 1940
Published: Aug. 19, 2023
Blueberries (BBs) are perennial fruits belonging to the Ericaceae family. BBs popular worldwide because of their high concentration bioactive compounds. have a long history usage as traditional healthy foods, but short shelf-life (less than 6 days under non-controlled conditions) is main reason for unavailability. Thus, processing different products better option time storage. this review highlighted nutritional importance BB and explored potential options long-time preservation consumption BBs. Moreover, addressed health benefits BBs-based food products. exhibited composition, especially anthocyanins (123.2–623.89 mg/100 g dry weight). Many technologies can be applied extend BBs, including drying, juicing, producing wine vinegar, using them additives. powder, juice, considered best prolong time. Additionally, exert excellent antioxidant, anti-obesity, anti-diabetic, anti-inflammatory, anti-microbial, anticancer activities. The cardioprotective, effects noticeable among all bioactivities. Therefore, developing commercial or BBs-components increase consumer acceptability.
Language: Английский
Citations
4
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1737 - 1737
Published: Dec. 17, 2023
Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin activities vivo are dependent on bioaccessibility and bioavailability, which have been highlighted as crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) shown to be effective encapsulation, they the potential enhance outcomes. This study evaluated effects of encapsulated within CNC-CTAB structures, namely antioxidant, anti-inflammatory antimicrobial properties, well release profile under digestion conditions intestinal permeability. Encapsulated antioxidant effectively reducing reactive oxygen species cytokine production by cells. The delivery system exhibited properties against Campylobacter jejuni bacteria, further suggesting mitigating inflammation. showed ability protect from degradation facilitate interaction epithelium, highlighting carrier
Language: Английский
Citations
4