Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Nov. 25, 2023
Gut
microbiota
plays
a
key
role
in
insulin
resistance
(IR).
Here
we
perform
case-control
study
of
Chinese
adults
(ChiCTR2200065715)
and
identify
that
Parabacteroides
distasonis
is
inversely
correlated
with
IR.
Treatment
P.
improves
IR,
strengthens
intestinal
integrity,
reduces
systemic
inflammation
mice.
We
further
demonstrate
distasonis-derived
nicotinic
acid
(NA)
vital
bioactive
molecule
fortifies
barrier
function
via
activating
G-protein-coupled
receptor
109a
(GPR109a),
leading
to
ameliorating
also
conduct
dietary
fiber
screening
induce
growth.
Dendrobium
officinale
polysaccharide
(DOP)
shows
favorable
growth-promoting
effects
on
protects
against
IR
mice
simultaneously.
Finally,
the
reduced
NA
levels
were
validated
another
human
type
2
diabetes
mellitus
cohort.
These
findings
reveal
unique
mechanisms
provide
viable
strategies
for
treatment
prevention
by
fiber.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(2), P. 217 - 217
Published: Feb. 18, 2024
Infectious
diseases
have
long
posed
a
significant
threat
to
global
health
and
require
constant
innovation
in
treatment
approaches.
However,
recent
groundbreaking
research
has
shed
light
on
previously
overlooked
player
the
pathogenesis
of
disease-the
human
microbiome.
This
review
article
addresses
intricate
relationship
between
microbiome
infectious
unravels
its
role
as
crucial
mediator
host-pathogen
interactions.
We
explore
remarkable
potential
harnessing
this
dynamic
ecosystem
develop
innovative
strategies
that
could
revolutionize
management
diseases.
By
exploring
latest
advances
emerging
trends,
aims
provide
new
perspective
combating
by
targeting
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9366 - 9366
Published: Aug. 29, 2024
The
human
gastrointestinal
tract
hosts
a
complex
and
dynamic
community
of
microorganisms
known
as
the
gut
microbiota,
which
play
pivotal
role
in
numerous
physiological
processes,
including
digestion,
metabolism,
immune
function.
Recent
research
has
highlighted
significant
impact
diet
on
microbiota
composition
functionality,
consequential
effects
host
health.
Concurrently,
there
is
growing
evidence
linking
to
inflammation,
key
factor
many
chronic
diseases
such
inflammatory
bowel
disease
(IBD),
obesity,
diabetes,
cardiovascular
(CVDs).
This
review
explores
how
dietary
components
influence
composition,
these
microbial
changes
affect
pathways,
therapeutic
implications
modulating
this
axis
for
prevention
management.
Beneficial
patterns,
Mediterranean
(MD)
plant-based
diets,
promote
diverse
balanced
supporting
anti-inflammatory
pathways.
Conversely,
Western
(WD),
high
saturated
fats
refined
sugars,
associated
with
dysbiosis
increased
inflammation.
With
all
links
between
three
variables
considered,
attempts
offer
thorough
examination
triangle
formed
by
food.
Medicine in Microecology,
Journal Year:
2022,
Volume and Issue:
14, P. 100070 - 100070
Published: Nov. 30, 2022
Dietary
fiber
intake
in
humans
is
nowadays
substantially
decreased
as
compared
to
the
communities
of
ancestral
populations.
Accompanying
that,
incidences
inflammatory
bowel
disease
(IBD),
allergy,
and
other
autoimmune
diseases
are
steadily
increasing
over
past
60
years,
especially
high-income
countries,
which
partly
attributed
changing
dietary
habit
modern
societies.
Chronic
inflammation
triggered
by
immune
disorders
central
part
pathophysiology
various
non-communicable
diseases.
inexorably
linked
gut
microbiome
leading
reduction
inflammation.
This
review
explores
how
fibers
modulate
microbiota
composition
function
alteration
host
physiology.
High-fiber
regime
has
been
consistently
shown
increase
alpha
diversity
short-chain
fatty
acids
(SCFAs)-producing
bacteria
human
gut.
SCFAs
main
players
interplay
between
diet,
microbiota,
health.
In
clinical
settings,
therapies
with
high
or
SCFA
supplementations
proposed
for
However,
due
greater
variations
dosage,
type,
duration
intervention
different
trials,
effects
remain
controversial.
Unraveling
mechanisms
exerted
synergy
holds
a
promising
prospect
guiding
next-generation
precision
therapies.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 11, 2023
Objective
Sepsis
is
the
leading
cause
of
death
in
critically
ill
patients.
The
gastrointestinal
tract
has
long
been
thought
to
play
an
important
role
pathophysiology
sepsis.
Antibiotic
therapy
can
reduce
a
patient’s
commensal
bacterial
population
and
raise
their
risk
developing
subsequent
illnesses,
where
gut
microbiota
dysbiosis
may
be
key
factor.
Methods
In
this
study,
we
analyzed
16S
rRNA
fecal
samples
from
both
healthy
people
patients
with
sepsis
determine
if
alterations
bacteria
are
associated
Then,
developed
mouse
model
using
cecal
ligation
puncture
(CLP)
order
examine
effects
transplantation
(FMT)
short-chain
fatty
acids
(SCFAs)
on
survival
rate,
systemic
inflammatory
response,
microbiota,
mucosal
barrier
function.
Results
patients’
composition
significantly
differed
that
people.
At
phylum
level,
amount
Proteobacteria
intestinal
flora
was
much
larger
than
control
group,
whereas
number
Firmicutes
lower.
Mice
disorders
(ANC
group)
were
found
have
elevated
death,
inflammation,
organ
failure
as
compared
CLP
mice.
However,
all
these
could
reversed
by
FMT
SCFAs.
SCFAs
regulate
abundance
such
Firmicutes,
Proteobacteria,
Escherichia
Shigella,
Lactobacillus,
restoring
them
levels
comparable
those
addition,
they
increased
expression
Occludin
protein
colon
mice
sepsis,
downregulated
NLRP3
GSDMD-N
proteins,
reduced
release
factors
IL-1β
IL-18
inhibit
cell
pyroptosis,
ultimately
playing
protective
Disccusion
provide
microbe-related
benefit
suggesting
viable
treatment
for
Foods,
Journal Year:
2023,
Volume and Issue:
12(10), P. 2010 - 2010
Published: May 16, 2023
Pleurotus
ostreatus
(Jacq.
ex
Fr.)
P.
Kumm
mushroom
contains
bioactive
compounds
with
both
antimicrobial
and
prebiotic
properties,
which
are
distributed
in
the
mycelium,
fruiting
body,
spent
substrate.
The
is
rich
nondigestible
carbohydrates
like
chitin
glucan,
act
as
prebiotics
support
growth
activity
of
beneficial
gut
bacteria,
thereby
maintaining
a
healthy
balance
microbiota
reducing
risk
antibiotic
resistance.
mushrooms,
including
polysaccharides
(glucans,
chitin)
secondary
metabolites
(phenolic
compounds,
terpenoids,
lectins),
exhibit
antibacterial,
antiviral,
antifungal
activities.
When
mushrooms
consumed,
these
can
help
preventing
spread
harmful
bacteria
gut,
infections
development
Nonetheless,
further
research
necessary
to
determine
efficacy
against
different
pathogens
fully
comprehend
its
properties.
Overall,
consuming
diet
mushroom-based
foods
have
positive
impact
on
human
digestion
health.
A
microbiome
reduce
need
for
antibiotics.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(22), P. 4722 - 4722
Published: Nov. 8, 2023
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
disease.
It
has
been
observed
that
the
incidence
prevalence
of
IBD
are
increasing,
which
consequently
raises
risk
developing
colon
cancer.
Recently,
regulation
intestinal
barrier
by
probiotics
become
an
effective
treatment
for
colitis.
Akkermansia
muciniphila-derived
extracellular
vesicles
(Akk
EVs)
nano-vesicles
contain
multiple
bioactive
macromolecules
with
potential
to
modulate
barrier.
In
this
study,
we
used
ultrafiltration
in
conjunction
high-speed
centrifugation
extract
Akk
EVs.
A
lipopolysaccharide
(LPS)-induced
RAW264.7
cell
model
was
established
assess
anti-inflammatory
effects
found
EVs
were
able
be
absorbed
cells
significantly
reduce
expression
nitric
oxide
(NO),
TNF-α,
IL-1β
(p
<
0.05).
We
explored
preventative
on
colitis
regulating
using
mouse
caused
dextran
sulfate
sodium
(DSS).
The
findings
demonstrated
effectively
prevented
symptoms
reduced
colonic
tissue
injury.
Additionally,
enhanced
effectiveness
elevating
MUC2
(0.53
±
0.07),
improving
mucus
integrity,
reducing
permeability
Moreover,
increased
proportion
beneficial
bacteria
Firmicutes
(33.01
0.09%)
downregulated
harmful
Proteobacteria
(0.32
0.27%).
These
suggest
possess
ability
regulate
immune
responses,
protect
barriers,
gut
microbiota.
research
presents
intervention
approach
prevent
