Effects of Saponins on Lipid Metabolism: The Gut–Liver Axis Plays a Key Role

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1514 - 1514

Published: May 17, 2024

Unhealthy lifestyles (high-fat diet, smoking, alcohol consumption, too little exercise, etc.) in the current society are prone to cause lipid metabolism disorders affecting health of organism and inducing occurrence diseases. Saponins, as biologically active substances present plants, have lipid-lowering, inflammation-reducing, anti-atherosclerotic effects. Saponins thought be involved regulation body; it suppresses appetite and, thus, reduces energy intake by modulating pro-opiomelanocortin/Cocaine amphetamine regulated transcript (POMC/CART) neurons neuropeptide Y/agouti-related peptide (NPY/AGRP) hypothalamus, control center. directly activate AMP-activated protein kinase (AMPK) signaling pathway related transcriptional regulators such peroxisome-proliferator-activated-receptors (PPAR), CCAAT/enhancer-binding proteins (C/EBP), sterol-regulatory element binding (SREBP) increase fatty acid oxidation inhibit synthesis. It also modulates gut–liver interactions improve regulating gut microbes their metabolites derivatives—short-chain acids (SCFAs), bile (BAs), trimethylamine (TMA), lipopolysaccharide (LPS), et al. This paper reviews positive effects different saponins on disorders, suggesting that axis plays a crucial role improving processes may used therapeutic target provide new strategies for treating disorders.

Language: Английский

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Enhancing Zinc Uptake through Dual-Modification of Cicer arietinum Protein

Journal of Food Biochemistry, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 26

Published: Oct. 31, 2023

Zinc is crucial for physiological processes; however, deficiency persists globally. Binding zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential solution deficiency. Mineral binding efficiency of the unmodified protein limited; hence, dual modification (succinylation ultrasonication) potentially used achieve higher efficiency. Enhancing uptake cellular health due its vital roles in various biological processes including enzymatic activity, DNA repair, immune function, antioxidant defense, hormone regulation, brain signaling, growth, gene expression, reproduction. Therefore, this research aimed develop chickpea protein-zinc complex evaluate influence on their physiochemical, bioavailability, mineral attributes. Succinylation exhibited significant improvements water-holding capacity by 28.73%, oil-holding 34.09%, solubility 5.46% as compared native complex. bioavailability increased 8.32%, there were notable increases 2.10%, retention 5.80%, transport 3.96%, respectively. Furthermore, approach resulted decrease particle size complex, with substantial reduction 73.25% an zeta value −21 mV succinylated As well, concurrently led decline 48.04% sulfhydryl (SH) content, coupled marked increase 21.92% surface hydrophobicity. In addition, uptake, retention, further enhanced 1.89, 3.34, 4.8% through modification. Our findings highlight that shows promising strategy enhancing techno-functional characteristics, zinc, which could be better platform developing vegan foods.

Language: Английский

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Gut microbiota and inflammatory factor characteristics in major depressive disorder patients with anorexia

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 2, 2024

Abstract Background This study aimed to explore the gut microbiota and inflammatory factor characteristics in major depressive disorder (MDD) patients with anorexia analyze correlation between factors, anorexia, HAMD scores. Methods 46 MDD healthy controls (HC) were included study. The divided into two groups according whether they had anorexia:20 without (MDA0 group) 26 (MDA1 group). We used Hamilton Depression Scale-24 (HAMD-24) evaluate depression status of all participants 16 S ribosomal RNA (16 rRNA)sequencing composition microbiota. Inflammatory factors peripheral blood such as C-reactive protein (CRP) detected using enzyme-linked immunosorbent assay (ELISA). Spearman’s analysis was scores, anorexia. Results 1). CRP significantly higher MDA0, MDA1, than HC. 2). An α-diversity shows: Simpson Pielou indices HC group are MDA1 ( P < 0.05). 3). β-diversity shows differences microbial communities group. 4). A showed that Blautia positively correlated level, whereas Faecalibacterium, Bacteroides, Roseburia, Parabacteroides negatively level. 5). receiver operating characteristic (ROC) curve drawn differential bacterial genera or biomarkers identify accompanied its area under (AUC) 0.85. ROC diagnose AUC 0.97. Conclusion suggested a distinct compared individuals, level CRP. more abundant CRP, might have influenced through

Language: Английский

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Anti‐obesity peptides from food: Production, evaluation, sources, and commercialization

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(2)

Published: March 1, 2025

The global obesity epidemic has heightened interest in natural solutions, with anti-obesity peptides emerging as promising candidates. Derived from food sources such plants, algae, marine organisms, and products like milk eggs, these combat through various mechanisms but face challenges production scalability. aim of this review is to explore their sources, mechanisms, measurement, synthesis methods, including innovative approaches de novo synthesis, proteomics, bioinformatics. Its unique contribution lies critically analyzing the current state research while highlighting novel techniques practical relevance addressing commercialization challenges, offering valuable insights for advancing peptide development. Diverse methods assessing properties are discussed, encompassing both vitro vivo experimental approaches, well alternatives. also explores integration cutting-edge technologies potential revolutionize scalability cost-effectiveness. Key findings assert that despite great fight against advances identification analysis, scalability, regulatory hurdles, bioavailability issues, high costs, consumer appeal persist. Future should use bioinformatics tools advanced screening identify design enhanced efficacy bioavailability, efficient cost-effective extraction purification sustainable practices utilizing byproducts industry, containing isolated versus whole materials clinical settings.

Language: Английский

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Influence of Food Type on Human Psychological–Behavioral Responses and Crime Reduction

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3715 - 3715

Published: Aug. 25, 2023

The purpose of this narrative review is to emphasize the importance food consumption and meal selection on mental health brain function, including psychological behavioral reactions such as mood, loving relationships, violence, criminal activity. Additionally, by being aware link between health, community can be encouraged make informed choices in order avoid unfavorable outcomes like criminality. Food behaviors are shifting significantly over world. There also significant changes sadness, happiness, well spread variety severity diseases that lead violent acts. intake have evolved last ten years accessibility options become easier more diverse. These modifications might both beneficial bad consequences. This article examines relationship its impact marital satisfaction. goal support or refute claim influences love, behavior, vice versa. Various diets an one's brain, influencing responses even insecurity has been demonstrated various studies a negative well-being, leading despair, loss conflict, violence. For example, herbal extracts flavonoids potential improve gut microbiota treat mood disorders. Understanding how gut-brain axis communicates help guide interventions for cognitive function. Since root most related type consumed, research addresses issue reduce cost treatment prevention crime delinquency at level consciously choosing consumed society. In other words, always better than cure.

Language: Английский

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Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 12, 2024

ABSTRACT Probiotics are live microorganisms that, when administered in adequate amounts, provide health benefits to the host. According International Society of Sports Nutrition (ISSN), probiotic supplementation can optimize health, performance, and recovery athletes at all stages their careers. Recent research suggests that probiotics improve immune system functions, reduce gastrointestinal distress, increase gut permeability athletes. Additionally, may with secondary could positively affect athletic performance through enhanced from fatigue, improved function, maintenance healthy tract function. The integration some strains into athletes' diets consumption multi‐strain compounds lead an improvement performance‐related aspects such as muscle pain, body composition, cardiorespiratory fitness. In summary, be beneficial for careers, amateur professional. This paper reviews progress on role improving energy metabolism reducing enhancing fatigue different levels.

Language: Английский

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