Effect of bisphenol A on the neurological system: a review update

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(1), P. 1 - 73

Published: Oct. 19, 2023

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins polycarbonate plastics, which are frequently used food storage baby bottles. However, bind mainly to estrogen receptors, interfering with various neurologic functions, its use a topic significant concern. Nonetheless, neurotoxicity has not been fully understood despite numerous investigations on disruptive effects. Therefore, this review aims highlight recent studies implications system. Our findings suggest that exposure impairs structural molecular brain changes, promoting oxidative stress, changing expression levels several crucial genes proteins, destructive effects neurotransmitters, excitotoxicity neuroinflammation, damaged blood-brain barrier function, neuronal damage, apoptosis effects, disruption intracellular Ca

Language: Английский

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The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12417 - 12417

Published: Aug. 4, 2023

Endocrine disruptor chemicals (EDCs) can have a harmful effect on the human body’s endocrine system and thus adversely affect development, reproduction, neurological, cardiovascular, immune systems metabolism in humans wildlife. According to World Health Organization, EDCs are mostly man-made found ubiquitously our daily lives, notably pesticides, metals, additives or contaminants food personal care products. Human exposure occurs through ingestion, inhalation, dermal contact. Bisphenol A (BPA) is proven EDC capable of mimicking blocking receptors altering hormone concentrations metabolism. Although consumed low doses, it stimulate cellular responses functions. In humans, BPA has been correlated with onset development several diseases. This literature review aimed verify effects male infertility using most recently published literature. Thus, this allowed us conclude that compound seems fertility, causing changes hormonal semen characteristics. However, these conclusions lack more robust reproducible scientific studies. Even so, since prevalence increasing, preventive measures must be taken ensure fertility.

Language: Английский

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Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

Toxics, Journal Year: 2023, Volume and Issue: 11(5), P. 409 - 409

Published: April 26, 2023

Hexabromocyclododecane (HBCD) is a non-aromatic compound belonging to the bromine flame retardant family and known persistent organic pollutant (POP). This accumulates easily in environment has high half-life water. With variety of uses, HBCD found house dust, electronics, insulation, construction. There are several isomers most studied α-, β-, γ-HBCD. Initially used as substitute for other retardants, polybrominated diphenyl ethers (PBDEs), discovery its role POP made use manufacturing restricted Europe countries. The adverse effects on human health have been piling, either result from accumulation or considering power an endocrine disruptor (ED). Furthermore, it also proven that detrimental neuronal system, cardiovascular liver, reproductive system. linked cytokine production, DNA damage, increased cell apoptosis, oxidative stress, reactive oxygen species (ROS) production. Therefore, this review aims compile recent studies regarding negative health, describing possible mechanisms by which acts toxic effects.

Language: Английский

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Structural insight into the mechanisms and interacting features of endocrine disruptor Bisphenol A and its analogs with human estrogen-related receptor gamma

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123549 - 123549

Published: Feb. 11, 2024

Bisphenol A (BPA) is a very important chemical from the commercial perspective. Many useful products are made it, so its production increasing day by day. It widely known that and analogs present in environment they enter our body through various routes on daily basis as we use things of this lives. BPA has already been reported to be an endocrine disruptor. Studies have shown binds strongly human estrogen-related receptor gamma (ERRγ) target it. This study seeks understand how it interacts with ERRγ. Molecular docking ERRγ was performed, estradiol taken reference. Then, physico-chemical toxicological analysis compounds performed. Subsequently, dynamic behavior ERRγ-BPA compound complexes studied molecular dynamics simulations over 500 ns, using simulated data, their binding energies were again calculated MM-PBSA method. We observed affinity much higher than estradiol, apart being toxic, can easily absorbed physicochemical properties similar those oral medicines. Therefore, facilitates understanding structure–activity relationship provides information about key amino acid residues interact compounds, which helpful design competitive inhibitors interrupt interaction In addition, will also developing new therapeutics.

Language: Английский

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Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 13 - 13

Published: Jan. 17, 2025

Endocrine-disrupting chemicals (EDCs) are natural or synthetic substances that able to interfere with hormonal systems and alter their physiological signaling. EDCs have been recognized as a public health issue due widespread use, environmental persistence the potential levels of long-term exposure implications in multiple pathological conditions. Their reported adverse effects pose critical concerns about warranting strict regulation. This is case bisphenol A (BPA), well-known EDC whose tolerable daily intake (TDI) was re-evaluated 2023 by European Food Safety Authority (EFSA), immune system has identified most sensitive BPA exposure. Increasing scientific evidence indicates can several hormone receptors, pathways interacting proteins, resulting complex, cell context-dependent response may differ among tissues. In this regard, neuronal important targets signaling now emerging players endocrine disruption. Here, we use its analogs proof-of-concept address detrimental on nervous highlight complex interrelationships within immune-neuroendocrine network (INEN). Finally, propose Receptor for Activated C Kinase 1 (RACK1), an target valuable screening tool, could serve central hub our toxicology model explain bisphenol-mediated INEN.

Language: Английский

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Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones

Environment International, Journal Year: 2024, Volume and Issue: 183, P. 108433 - 108433

Published: Jan. 1, 2024

Pregnant women are exposed to numerous endocrine disrupting chemicals (EDCs) that can affect hormonal pathways regulating pregnancy outcomes and fetal development. Thus, we evaluated overall sex-specific associations of phthalate/replacement, paraben, phenol biomarkers with sex-steroid thyroid hormones. Illinois (n=302) provided plasma for progesterone, estradiol, testosterone, free T4 (FT4), total (TT4), stimulating hormone (TSH) at median 17 weeks gestation. Women also up-to-five first-morning urine samples monthly across (8-40 weeks), which pooled measure 19 phthalate/replacement metabolites (reflecting ten parent compounds), three parabens, six phenols. We used linear regression evaluate hormones, as well weighted quantile sum Bayesian kernel machine (BKMR) assess cumulative associations, non-linearities, chemical interactions. In relatively high socioeconomic status, several EDC were associated select without or non-linear FT4, TT4. The biomarker mixture was negatively estradiol (only higher concentrations using BKMR), TSH, where each 10% increase -5.65% (95%C.I.: -9.79, -1.28) lower testosterone -0.09 μIU/mL (95%CI: -0.20, 0.00) TSH. Associations FT4 did not differ by sex. However, in carrying females, identified an inverted u-shaped relationship the estradiol. Additionally, 1.50% -0.15, 3.18) TT4, whereas males, -1.77% -4.08, 0.58) TT4 -0.18 -0.33, -0.03) Some early-to-mid There some associations. Future studies could consider how these findings relate pregnancy/birth outcomes.

Language: Английский

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Bisphenol A triggers apoptosis in mouse pre-antral follicle granulosa cells via oxidative stress

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 16, 2024

Abstract Background Bisphenol A (BPA), an endocrine disrupting chemical with weak estrogenic and anti-androgenic activity, is widely present in various environmental media organisms. It has certain reproductive toxicity can cause a variety of female system diseases. Although BPA-stimulated apoptosis granulosa cells been elaborated, the effect BPA on mouse pre-antral follicle (mpGCs) not well elucidated. Results In this study, results live-dead cell staining showed that high concentrations severely impaired mpGCs growth viability affected cycle transition mpGCs. We confirmed promotes production reactive oxygen species (ROS) facilitates oxidative stress addition, immunofluorescence, transmission electron microscopy, flow cytometry experiments demonstrated treatment for resulted apoptotic features, such as rounding, cytoplasmic crinkling, mitochondrial damage. This was accompanied by large ROS apoptosis-inducing factor (AIF) translocation from mitochondria to nucleus. RNA-seq data several apoptosis-related pathways were enriched concentration BPA-treated group compared normal group, p53 pathway, MAPK etc. Conclusions These suggest undergo effects after mpGCs, which affects development. The potential mechanism BPA-induced elucidated, while providing research basis prevention

Language: Английский

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Association between exposure to per- and polyfluoroalkyl substances and levels of lipid profile based on human studies

Reviews on Environmental Health, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 26, 2024

Epidemiological evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) is associated with lipid profile levels, but inconsistent conclusions from different studies. The aim of this study was conduct a meta-analysis the relationship between PFAS levels based on population-based epidemiological Embase, PubMed, Ovid database, Cochrane Library Web Science database were used search appropriate studies (before September 6, 2022) correlation levels.

Language: Английский

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Health risks of Bisphenol-A exposure: From Wnt signaling perspective

Environmental Research, Journal Year: 2024, Volume and Issue: 251, P. 118752 - 118752

Published: March 20, 2024

Language: Английский

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Maternal–Foetal Effects of Exposure to Bisphenol A: Outcomes and Long-Term Consequences

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 697 - 697

Published: Jan. 12, 2025

Exposure to bisphenol A (BPA), one of the most widely produced plasticisers, can have a major effect on growing embryo and mother during pregnancy; as this is vulnerable period, cutoff established in legislation does not take factor into account. Thus, narrative review aims highlight consequences for foetus pregnant woman maternal foetal exposure BPA by analysing epidemiological experimental studies humans. Extensive research has examined effects several systems outcomes. Specifically, affects immune system offspring promotes development respiratory diseases, including asthma wheezing. Moreover, been negatively associated with children’s neurodevelopment, leading behavioural changes; autism; reproductive changes, mainly deviations anogenital distance, sexual hormone levels maturation, which result infertility. Furthermore, mothers, may be linked pre-eclampsia gestational diabetes mellitus birth parameters, higher risk preterm delivery, shorter lengths lower weights, although results were always consistent. These demonstrate urgent need stricter banning use pregnancy reduce hazards health unborn child.

Language: Английский

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