Antibiotic-Loaded Platelet-Rich Fibrin (AL-PRF) as a New Carrier for Antimicrobials: A Systematic Review of In Vitro Studies DOI Open Access
Wojciech Niemczyk,

Jacek Żurek,

Stanisław Niemczyk

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2140 - 2140

Published: Feb. 27, 2025

Platelet-rich fibrin (PRF) has emerged as a promising scaffold for drug delivery, particularly in the context of antimicrobial therapies. This systematic review evaluates incorporation antibiotics into PRF to determine its efficacy localized delivery system compared plain without antibiotics. A was conducted according Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including 13 vitro studies with moderate risk bias. Antibiotics were incorporated using different methodologies, systemic administration before blood collection, addition centrifugation, injection formed matrices. Outcomes analyzed regarding antibacterial efficacy, structural integrity PRF, release kinetics. Antibiotic-enhanced demonstrated significant activity against various bacterial strains. The enhanced dependent on type antibiotic, concentration, method. Encapsulation approaches facilitated sustained antibiotic release, while higher concentrations occasionally disrupted integrity. Systemic collection enriches effectively, producing inhibition zones. effects outperformed alternative carriers, such collagen sponges. Antibiotic-loaded is potent tool applications clinical settings. Further research needed standardize preparation protocols explore impact methods PRF's regenerative properties.

Language: Английский

Antibiotic-Loaded Platelet-Rich Fibrin (AL-PRF) as a New Carrier for Antimicrobials: A Systematic Review of In Vitro Studies DOI Open Access
Wojciech Niemczyk,

Jacek Żurek,

Stanisław Niemczyk

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2140 - 2140

Published: Feb. 27, 2025

Platelet-rich fibrin (PRF) has emerged as a promising scaffold for drug delivery, particularly in the context of antimicrobial therapies. This systematic review evaluates incorporation antibiotics into PRF to determine its efficacy localized delivery system compared plain without antibiotics. A was conducted according Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including 13 vitro studies with moderate risk bias. Antibiotics were incorporated using different methodologies, systemic administration before blood collection, addition centrifugation, injection formed matrices. Outcomes analyzed regarding antibacterial efficacy, structural integrity PRF, release kinetics. Antibiotic-enhanced demonstrated significant activity against various bacterial strains. The enhanced dependent on type antibiotic, concentration, method. Encapsulation approaches facilitated sustained antibiotic release, while higher concentrations occasionally disrupted integrity. Systemic collection enriches effectively, producing inhibition zones. effects outperformed alternative carriers, such collagen sponges. Antibiotic-loaded is potent tool applications clinical settings. Further research needed standardize preparation protocols explore impact methods PRF's regenerative properties.

Language: Английский

Citations

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