Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 10, 2024
Language: Английский
Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(5), P. 102064 - 102064
Published: April 7, 2024
Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for treatment of HCC; however, reported response rate to such therapeutic suboptimal (<3%). Piperine (PIP) an alkaloid demonstrated exert direct tumoricidal activity HCC and improve pharmacokinetic profiles anticancer drugs including SORA. In this study, we developed strategy efficacy outcomes using PIP as add-on support first-line SORA biodegradable Poly (D, L-Lactide-co-glycolide, PLGA) nanoparticles (NPs). (both exhibit low aqueous solubility) were co-loaded into PLGA NPs (PNPs) stabilized with various concentrations polyvinyl alcohol (PVA). The PIP-loaded PNPs (SP-PNPs) characterized Fourier Transform Infrared (FTIR) Spectroscopy, X-ray Powder Diffraction (XRD), Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Release these from SP-PNPs was investigated vitro at both physiological acidic pH, kinetic models employed assess mechanism drug release. against cells (HepG2) also evaluated. FTIR XRD analyses revealed that encapsulated amorphous state, no observed chemical interactions among or excipients. Assessment release pH 5 7.4 showed loaded 0.5 % PVA released sustained manner, unlike pure drugs, which exhibited relatively fast spherical, had average size 224 nm, encapsulation efficiency (SORA ∼ 82 %, 79 %), well superior cytotoxicity compared monotherapy vitro. These results suggest combining may be effective set comprehensive vivo study evaluate safety novel formulation murine model.
Language: Английский
Citations
10
Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(6)
Published: Jan. 16, 2024
Abstract Breast cancer has overtaken lung as the number one worldwide. Paclitaxel (PTX) is a widely used first‐line anti‐cancer drug, but it not very effective in clinical breast therapy. It been reported that triptolide (TPL) can enhance anticancer effect of paclitaxel, and better synergistic therapeutic effects are seen with concomitant administration PTX TPL. In this study, we developed pH‐responsive polymeric micelles for co‐delivery TPL, which disassembling acidic tumour microenvironments to target drug release effectively kill cells. Firstly, synthesized amphiphilic copolymer mPEG 2000 ‐PBAE through Michael addition reaction, confirmed by various characterizations. Polymer loaded TPL (TPL/PTX‐PMs) were prepared thin film dispersion method. The average particle size TPL/PTX‐PMs was 97.29 ± 1.63 nm, PDI 0.237 0.003 Zeta potential 9.57 0.80 mV, LC% 6.19 0.21%, EE% 88.67 3.06%. Carrier material biocompatibility micelle cytotoxicity assessed using CCK‐8 method, demonstrating excellent biocompatibility. Under same concentration, most toxic cells had strongest proliferation inhibitory effect. Cellular uptake assays revealed significantly increased intracellular concentration enhanced antitumor activity. Overall, micellar promising approach
Language: Английский
Citations
9
Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(6), P. 672 - 706
Published: April 29, 2024
Recent advances in the field of drug delivery have opened new avenues for development novel nanodrug systems (NDDS) cancer therapy. Self-assembled nanoparticles (SANPs) based on tumour microenvironment great advantages improving antitumor effect, and pH-responsive SANPs prepared by combination nanomaterials self-assembly technology can effectively improve efficacy reduce systemic toxicity drugs. In this review, we describe characteristics its driving force, mechanism NDDS, type. A series tumour-targeted are discussed, with an emphasis relation between structural features theranostic performance.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Virus-like particles (VLPs), as a unique form of nanocarrier, predominantly encompass hollow protein shells that exhibit analogous morphology and structure to naturally occurring viruses, yet devoid genetic material. VLPs are considered safe, easily modifiable, stable, making them suitable for preparation in various expression systems. They serve precise biological instruments with broad applications the field medical biology. Leveraging their structural attributes facile modification capabilities, can an effective platform delivery tumor antigens, thereby stimulating immune system facilitating eradication cells.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2023, Volume and Issue: 17(24), P. 24593 - 24618
Published: Dec. 6, 2023
Tumor immunotherapy is a safe and effective strategy for precision medicine. However, most cancer cases still ends in failure, with the root causes of immunosuppressive extraordinary heterogeneity solid tumors microenvironment. The emerging biomimetic nanodelivery system provides promising tactic to improve effect while reducing adverse reactions on nontarget cells. Herein, we summarize relationship between tumor occurrence immune microenvironment, mechanism escape, classification (including adoptive cellular therapy, cytokines, vaccines, checkpoint inhibitors) recommend target cells first, then emphatically introduce recent advances applications latest systems (e.g., cells, erythrocytes, platelets, bacteria) immunotherapy. Meanwhile, separately application vaccines. Finally, predictable challenges perspectives forward exploration are also discussed.
Language: Английский
Citations
22
International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(3), P. 789 - 810
Published: Jan. 1, 2023
Cancer has been considered as complex malignant consequence of genetic mutations that control the cellular proliferation, differentiation and homeostasis, thus making tumor treatment extremely challenging.To date, a variety cargo molecules, including nucleic acids drugs (pDNA, miRNA siRNA), therapeutic (doxorubicin, paclitaxel, daunomycin gefitinib) imaging agents (radioisotopes, fluorescence dyes, MRI contrast agents) have regarded potential medicines in clinical application.However, non-single drug could induce satisfied results because heterogeneity multiple resistance nanotechnology-based combined therapy is becoming an advanced important mode for enhanced anticancer effects.The review gathers current development to co-deliver small-molecular with nanomedicine-based combination.Furthermore, superiority definitely presented barriers are detail discussed surmount challenges.In final, future perspectives rational direction exhibited.
Language: Английский
Citations
21
Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10
Published: Aug. 7, 2023
DNA origami is a cutting-edge self-assembly technique that neatly folds strands and creates specific structures based on the complementary base pairing principle. These innovative nanostructures provide numerous benefits, including lower biotoxicity, increased stability, superior adaptability, making them an excellent choice for transporting anti-tumor agents. Furthermore, they can considerably reduce side effects improve therapy success by offering precise, targeted, multifunctional drug delivery system. This comprehensive review looks into principles design strategies of origami, providing valuable insights this technology’s latest research achievements development trends in field delivery. Additionally, we key function major benefits cancer treatment, some these approaches also involve aspects related to tetrahedra, aiming novel ideas effective solutions address challenges therapy.
Language: Английский
Citations
21
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115331 - 115331
Published: Aug. 18, 2023
Elemene (ELE) is a group of broad-spectrum anticancer active ingredients with low toxicity extracted from traditional Chinese medicines (TCMs), such as Curcumae Rhizoma and Curcuma Radix, which can exert antitumour activities by regulating various signal pathways targets. However, the strong hydrophobicity, short half-life, bioavailability weak in vivo targeting ability ELE restrict its use. Targeted drug delivery systems based on nanomaterials are among most viable methods to overcome these shortcomings. In this review, we first summarize recent studies clinical uses an adjunct drug. ELE-based combination strategies have great promise for enhancing efficacy, reducing adverse reactions, improving patients' quality life immune function. Second, mechanisms strategies. The potential include inducing pyroptosis ferroptosis, promoting senescence, METTL3-mediated m6A modification, suppressing Warburg effect, apoptosis cell cycle arrest. Most importantly, comprehensively targeted ELE, including passively actively systems, stimuli-responsive codelivery combined other therapies, bioavailability, increasing ability, controlling release, effects reversing MDR. Our summary will provide reference TCMs advanced future.
Language: Английский
Citations
21
Journal of Sol-Gel Science and Technology, Journal Year: 2023, Volume and Issue: 106(3), P. 726 - 736
Published: April 14, 2023
Language: Английский
Citations
20
Chinese Medical Journal, Journal Year: 2023, Volume and Issue: 136(16), P. 1910 - 1922
Published: July 5, 2023
Esophageal cancer (EC) is one of the most common aggressive malignant tumors in digestive system with a severe epidemiological situation and poor prognosis. The early diagnostic rate EC low, patients are diagnosed at an advanced stage. Multiple multimodality treatments have gradually evolved into main treatment for EC, including surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy. And emergence therapy immunotherapy has greatly improved survival patients. This review highlights latest advances discusses efficacy safety relevant drugs, summarizes related important clinical trials, tries to provide references therapeutic strategy EC.
Language: Английский
Citations
18