Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity

Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 659 - 659

Published: Feb. 19, 2023

Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens currently in clinical use. However, precise mechanisms DOX’s action are not fully understood. Emerging evidence points to pleiotropic anticancer activity DOX, including its contribution DNA damage, reactive oxygen species (ROS) production, apoptosis, senescence, autophagy, ferroptosis, and pyroptosis induction, as well immunomodulatory role. This review aims collect information on DOX influence anti-tumor immune response, providing a rationale behind importance modern cancer therapy.

Language: Английский

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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

Language: Английский

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Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core‐Shell Manganese Phosphate/siPD‐L1 Modulator

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

ABSTRACT The insufficient infiltration and functional inhibition of CD8 + T cells due to tumor microenvironment (TME) are considered enormous obstacles anti‐tumor immunotherapy. Herein, a pH‐responsive core‐shell manganese phosphate nanomodulator co‐loading siPD‐L1 Mn 2+ into nanoparticles coated with hyaluronic acid was prepared, which aimed at the bidirectional reprogramming microenvironment: (1) “Brakes off,” restoring function by knockdowning PD‐L1 expression cells; (2) “Step on accelerator,” promoting in tumors tissue based multidimensional immune effects (immunogenic cell death induced enhancing cGAS‐STING pathway, proliferation maturation relative cells). Additionally, this strategy could induce macrophage polarization inhibit regulatory site. This work provided reprogram TME for an enhanced comprehensive effect triple negative breast cancer, offers robust method immunotherapy future clinical applications.

Language: Английский

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Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2932 - 2932

Published: March 2, 2024

Kaposi’s sarcoma-associated herpesvirus (KSHV) can cause a variety of malignancies. Ganciclovir (GCV) is one the most efficient drugs against KSHV, but its non-specificity other side effects in patients. Nucleic acid miR-34a-5p inhibit transcription KSHV RNA and has great potential anti-KSHV therapy, there are still problems such as easy degradation low delivery efficiency. Here, we constructed co-loaded dual-drug nanocomplex (GCV@ZIF-8/PEI-FA+miR-34a-5p) that contains GCV internally adsorbs externally. The folic (FA)-coupled polyethyleneimine (PEI) coating layer (PEI-FA) was shown to increase cellular uptake nanocomplex, which conducive enrichment at infection site. released site through hydrolysis characteristics ZIF-8 “proton sponge effect” PEI. not only inhibits proliferation migration KSHV-positive cells also decreases mRNA expression level lytic latent genes. In conclusion, this may provide an attractive strategy for antiviral drug therapy.

Language: Английский

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The Cutting Edge Quest: Epic Saga of Carboxymethyl Guar Gum in Drug Delivery and Roads Ahead

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT The search for novel drug delivery systems has generated great interest in biopolymer‐based carriers. Among these, carboxymethyl guar gum (CMGG) been shown to be promising. CMGG is a chemically modified derivative of that synthesized by carboxymethylation with monochloroacetic acid and sodium hydroxide under optimized conditions. This improves the physicochemical properties polysaccharide, which are enhanced hydrophilicity, viscosity, swelling behavior compared unmodified Guar gum. review focuses on wide applications systems, thus underlining its versatility as an excipient based unique properties. Key features such pseudoplasticity allow effective drugs controlled‐release systems. Advanced characterization techniques, like Fourier Transform Infrared Spectroscopy Nuclear Magnetic Resonance (NMR) spectroscopy, confirm structural changes due carboxymethylation; further aspects emphasized rheological studies, highlight applicability pharmaceutical fields. biocompatibility biodegradability add advantages, offering safety compatibility environment therapeutic applications. capacity enclose hydrophilic well control release profiles shows promise efficacy enhancement patient safety. puts forward represents excellent means development enhancing outcomes.

Language: Английский

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New insights into the antimicrobial action and protective therapeutic effect of tirapazamine towards Escherichia coli-infected mice

International Journal of Antimicrobial Agents, Journal Year: 2023, Volume and Issue: 62(3), P. 106923 - 106923

Published: July 9, 2023

Language: Английский

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The siEGFR nanoplexes for the enhanced brain glioma treatment: Endoplasmic reticulum biomimetic strategy to induce homing effect and non-degradable intracellular transport

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117413 - 117413

Published: Sept. 10, 2024

Language: Английский

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Novel inhibitor against Rac1 for therapeutic approach in prevention of breast cancer progression

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 23, 2024

Metastatic breast-cancer is one of the major causes death, due to remaining dormant cancer cells for several years. Rac1 upregulated with and stay elevated throughout metastatic pathway regulate formation lamellipodia filopodia. This work developed peptide FGDWS as novel inhibitor targeting Rac1-Tiam1 binding site by in-silico it was found be strongest interacting at Tiam site. The inhibition study performed Surface plasmon resonance MTT assay, respectively. Cell-migration, apoptotic assay western-blot in were combination Doxorubicin (Dox). Tumor regression experiment done mice model. strong reduction cell-viability observed cell-lines. cell-migration suppressed, higher obtained synergy group. effect alone Dox detected annexin-V via activating caspase3/7. tumor size reduced treatment more combinatorial effect. FGDWS-Dox may enhance efficacy without side-effects.

Language: Английский

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INVESTIGATION OF THE EFFECT OF COPPER OXIDE NANOPARTICLES ON THE EFFICACY OF METHOTREXATE AND PACLITAXEL IN MCF-7 BREAST CANCER CELLS

Studies in Medical Sciences, Journal Year: 2024, Volume and Issue: 35(8), P. 662 - 674

Published: Nov. 1, 2024

Language: Английский

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Bioengineered chimeric tRNA/pre‐miRNAs as prodrugs in cancer therapy

Biotechnology Progress, Journal Year: 2023, Volume and Issue: 39(6)

Published: Aug. 22, 2023

Abstract Today, biologic prodrugs have led to targeting specific tumor markers and increased specificity selectivity in cancer therapy. Various studies shown the role of ncRNAs pathology tumorigenesis suggested that ncRNAs, especially miRNAs, are valuable molecules understanding biology therapeutic processes. Most miRNAs‐based research treatment limited chemically synthesized miRNAs. Synthetic alterations these miRNA mimics may affect their folding, safety profile, even biological activity. However, despite synthetic produced by automated systems, various carriers could be used achieve efficient production bioengineered miRNAs through economical microbial fermentation. These as provide a new approach for safe methods drug production. In this regard, chimeric selectively processed mature different types cells desired gene regulating progression. article, we aim review use therapy, well offering advances area, including tRNA/pre‐miRNAs.

Language: Английский

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