Unveiling the Hidden Links: Periodontal Disease, Fusobacterium Nucleatum, and Cancers

Current Oncology Reports, Journal Year: 2024, Volume and Issue: 26(11), P. 1388 - 1397

Published: Aug. 12, 2024

Language: Английский

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Role of Oral Microbiota Balance and Probiotic Therapy in Radiation-Induced Oral Mucositis

Published: Jan. 1, 2025

Radiation therapy (RT) is a key treatment for head and neck cancers but often leads to radiation-induced oral mucositis (ROM), exacerbated by disruptions in the microbiota. Imbalances microbial ecosystem increase mucosal vulnerability radiation, worsening ROM. Probiotics present promising intervention restoring balance, enhancing barrier, reducing inflammation, producing antimicrobial agents vital health during RT. Studies have shown probiotics' efficacy treating ulcers, focusing on strain selection, dosage, synergy with conventional therapies. However, challenges persist, including specificity, interactions other treatments, safety concerns. This review explores role of microbiota mitigating ROM, emphasizing need innovative probiotic formulations, advanced delivery systems, integration novel Maintaining balance leveraging therapies hold potential improving ROM management future research.

Language: Английский

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Phytochemical Characterization of Essential Oils from Plants of the Genus Cinnamomum and their Effect on Diarrhea and Disruption of the Intestinal Epithelium Induced by 5-FU

Journal of Advances in Biology & Biotechnology, Journal Year: 2025, Volume and Issue: 28(1), P. 481 - 490

Published: Jan. 17, 2025

Aims: This article aims to evaluate the phytochemical characteristics and biological activity of Cinnamomum cassia Blume zeylanicum essential oils, specifically their effects on weight loss, diarrhea, epithelial damage in a murine model 5-fluorouracil-induced intestinal mucositis. Study Design: The study consisted controlled experimental design using therapeutic potential oils mucositis induced by chemotherapy with 5-FU. Location: research was conducted at Medicinal Plant Research Center (NPPM), Federal University Piauí, State Brazil. Methodology: included albino (swiss) mus muscullus mice weighing 30-40 g, divided into different groups (n = 7 per group) analyze administered orally. Essential were extracted from bark species characterized gas chromatography-mass spectrometry (GC-MS). Mucositis 5-fluorouracil (5-FU), animals assessed measuring animal body mass, diarrhea score, assessing lactate dehydrogenase release. Results: analysis showed that both contained predominantly cinnamaldehyde, significant variation diversity. Treatment attenuated loss severity 5-FU-induced diarrhea. Specifically, highest dose (50 mg/kg/day) significantly reduced levels, indicating damage. Statistical one-way ANOVA followed Bonferroni's post-test, results showing differences (p < 0.05) treatment compared control group. Conclusion: contributes theory observed beneficial can be attributed distinct compositions. While oil exhibits greater diversity, is higher proportion constituting approximately 80% its composition. more pronounced may suggest synergistic dynamic where high cinnamaldehyde content plays critical role, highlighting importance specific concentrations compounds achieve efficacy.

Language: Английский

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Effect of blood oxidative stress indicators on oral mucositis in patients undergoing radiotherapy for nasopharyngeal carcinoma

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 30, 2024

Language: Английский

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