The Effect of Antidepressant Treatment on Neurocognitive Functions, Redox and Inflammatory Parameters in the Context of COVID-19 DOI Open Access

Eliza Samaryn,

Beata Galińska-Skok, Aleksander Nobis

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(22), P. 7049 - 7049

Published: Nov. 12, 2023

Inflammation is an important component of the etiopathology depression that uses oxidative and nitrosative stress (O&NS) elevated inflammatory markers. SARS-CoV-2 infection also associated with abnormal processes, which may impair effective treatment in COVID-19 survivors. In presented study, thirty-three hospitalized patients major depressive disorder (MDD) were started on antidepressant treatment, twenty-one re-evaluated after 4–6 weeks. The control group consisted thirty healthy volunteers. All participants underwent neuropsychiatric evaluation, biochemical blood urine analyses. results research demonstrated positive correlations Hamilton Depression Rating Scale (HAM-D) scores serum catalase (CAT) urinary S-Nitrosothiols levels, Beck Inventory (BDI) reduced glutathione (GSH) superoxide dismutase (SOD) levels. Depressed a history prior to had higher nitric oxide (NO) levels lower peroxidase (GPx) group, survivors N-formylkynurenine (NFK). Our suggest has modulating effect O&NS, reduces symptoms improves cognitive functions present study does not indicate clinical response baseline antibody Nevertheless, further this area needed systematize

Language: Английский

Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies DOI Creative Commons
Mohammad Aatif

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 2078 - 2078

Published: July 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Language: Английский

Citations

46
The antiglycation potential of H1 receptor antagonists – in vitro studies in bovine serum albumin model and in silico molecular docking analyses DOI Open Access
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116632 - 116632

Published: April 24, 2024

The H1 receptor belongs to the family of rhodopsin-like G-protein-coupled receptors activated by biogenic amine histamine. antagonists are widely used in treatment allergies. However, these drugs could have a much broader spectrum activity, including hypoglycemic effects, which can broaden their use. aim study was evaluate antiglycation potential twelve (diphenhydramine, antazoline, promethazine, ketotifen, clemastine, pheniramine, cetirizine, levocetirizine, bilastine, fexofenadine, desloratadine, and loratadine). Bovine serum albumin (BSA) glycated with sugars (glucose, fructose, galactose, ribose) aldehydes (glyoxal methylglyoxal) presence blockers. tested substances did not induce significant decrease content glycation end-products, inhibition rate glycoxidation influenced chemical structure or generation None exhibited strong activity. Antiglycemic blockers be attributed antioxidant anti-inflammatory as well effects on carbohydrate metabolism/metabolic balance at systemic level.

Language: Английский

Citations

5
Novel Properties of Old Propranolol─Assessment of Antiglycation Activity through In Vitro and In Silico Approaches DOI Creative Commons
Kamil Klaudiusz Lauko, Miłosz Nesterowicz, Daria Trocka

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(25), P. 27559 - 27577

Published: June 11, 2024

Hypertension has earned the "silent killer" nickname since it may lead to a number of comorbidities, including diabetes and cardiovascular diseases. Oxidative stress protein glycation play vital roles in pathogenesis hypertension. Several studies have shown that they profoundly account for vascular dysfunction, endothelial damage, disruption blood pressure regulatory mechanisms. Of particular note are advanced end products (AGEs). AGEs alter tissues' functional mechanical properties by binding receptors (RAGE), stimulating inflammation free radical-mediated pathways. Propranolol, nonselective beta-adrenergic receptor antagonist, is one most commonly used drugs treat hypertension Our study first analyze propranolol's effects on glycoxidation through vitro silico approaches. Bovine serum albumin (BSA) was utilized evaluate inhibition propranolol. Propranolol (1 mM) BSA (0.09 were incubated with different glycating (0.5 M glucose, fructose, galactose 6 days 2.5 mM glyoxal methylglyoxal 12 h) or oxidizing agents (chloramine T 1 h). Biomarkers (Amadori (APs), β-amyloid (βA), (AGEs)), (dityrosine (DT), kynurenine (KYN), N-formylkynurenine (NFK)), oxidation (protein carbonyls (PCs), (AOPPs)) measured means colorimetric fluorimetric methods. The scavenging reactive oxygen species (hydrogen peroxide, hydroxyl radical, nitric oxide) antioxidant capacity (2,2-diphenyl-1-picrylhydrazyl radical ferrous ion chelating (FIC) assays)) propranolol also evaluated. Additionally, docking performed showcase interaction BSA, glycosides, AGE/RAGE pathway proteins. (↓APs, ↓βA, ↓AGEs), (↓DT, ↓KYN, ↓NFK), (↓PCs, ↓AOPPs) prominently decreased samples both glycating/oxidizing factors antiglycoxidant similar those aminoguanidine, known inhibitor, captopril, which an established antioxidant. showed potent activity FIC H2O2 assays, comparable aminoguanidine captopril. In analysis indicated antiglycative during its glycosidases, results confirm decrease vitro. Additional human animal models vivo verification antiglycation activity, as this discovery might hold key prevention diabetic complications among cardiology-burdened patients.

Language: Английский

Citations

4
A comparative study on the antioxidant and antiglycation properties of different vitamin D forms DOI Creative Commons
Cezary Pawlukianiec, Kamil Klaudiusz Lauko, Daniel Michalak

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 285, P. 117263 - 117263

Published: Jan. 10, 2025

Language: Английский

Citations

0
Potential Health Benefits of Polyphenols and Their Nanoformulations in Humans DOI
Mohd Farhan, Mohammad Aatif

Published: Jan. 1, 2025

Language: Английский

Citations

0
Inhibition of protein glycation by vasodilatory β-blockers – In vitro studies and in silico analyses DOI
Szymon Drygała, Małgorzata Żendzian‐Piotrowska,

Michał Radzikowski

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117976 - 117976

Published: March 12, 2025

Language: Английский

Citations

0
Carbon Monoxide: A Pleiotropic Redox Regulator of Life and Death DOI Creative Commons
Andrey Y. Abramov, Isabella Myers,

Plamena R. Angelova

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1121 - 1121

Published: Sept. 16, 2024

Despite recent technological progress, carbon monoxide poisoning is still one of the leading causes domestic and industrial morbidity mortality. The brain particularly vulnerable to CO toxicity, thus majority survivors develop delayed movement cognitive complications. binds haemoglobin in erythrocytes, preventing oxygen delivery tissues, additionally inhibits mitochondrial respiration. This renders effect be closely related hypoxia reperfusion injury. Oxygen deprivation, as well re-oxygenation, are shown able activate production reactive species induce oxidative stress. Here, we review role stress mechanism neuronal cell death induced by re-oxygenation. We discuss possible protective mechanisms used cells with a specific focus on inhibition CO-induced ROS

Language: Английский

Citations

2
Agomelatine's antiglycoxidative action—In vitro and in silico research and systematic literature review DOI Creative Commons
Miłosz Nesterowicz, Kamil Klaudiusz Lauko, Małgorzata Żendzian‐Piotrowska

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: April 25, 2023

Introduction Agomelatine is an atypical antidepressant drug enhancing norepinephrine and dopamine liberation; nevertheless, additional mechanisms are considered for the drug's pharmacological action. Since protein glycoxidation plays a crucial role in depression pathogenesis, agomelatine's impact on carbonyl/oxidative stress was research purpose. Methods Reactive oxygen species scavenging (hydroxyl radical, hydrogen peroxide, nitrogen oxide) antioxidant capacity (2,2-diphenyl-1-picrylhydrazyl radical ferrous ion chelating assays) of agomelatine were marked. Agomelatine's antiglycoxidation properties assayed sugars (glucose, fructose, galactose) aldehydes- (glyoxal methylglyoxal) glycated bovine serum albumin (BSA). Aminoguanidine α-lipoic acid used as standard glycation/oxidation inhibitors. Results did not show meaningful scavenging/antioxidant vs. standards. Sugars/aldehydes increased glycation (↑kynurenine, ↑N-formylkynurenine, ↑dityrosine, ↑advanced end products, ↑β-amyloid) oxidation (↑protein carbonyls products) parameters addition to BSA. Standards restored BSA baselines markers, unlike which sometimes even intensifies above + glycators levels. Molecular docking analysis demonstrated its very weak binding affinity. Discussion low affinity could proclaim non-specific bonding simplify attachment factors. Thereby, may stimulate brain adaptation systematic review indicates. Moreover, active metabolites exert antiglycoxidative effect.

Language: Английский

Citations

6
Biochemical and Biophysical in Vitro Studies and Systematic Literature Review on the Antioxidant and Antiglycation Activities of Trazodone DOI Creative Commons
Miłosz Nesterowicz, Małgorzata Żendzian‐Piotrowska, Jerzy Robert Ładny

et al.

Cellular Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 57(2), P. 82 - 104

Published: March 29, 2023

Background/Aims: Trazodone is a selective serotonin reuptake inhibitor; however, other mechanisms of the drug’s anti-depressive properties have also been postulated. Hence, aim study was to perform systematic review and assess antiglycoxidative trazodone in vitro models. Methods: Trazodone’s scavenging chelating were measured with spectrophotometric method. The impact drug on carbonyl/oxidative stress marked bovine serum albumin (BSA) model where sugars (glucose, fructose, galactose, ribose) aldehydes (glyoxal methylglyoxal) used as glycation agents. Aminoguanidine N-acetylcysteine (NAC) applied reference glycation/free radical inhibitors. Glycation biomarkers (kynurenine, N-formylkynurenine, dityrosine well advanced end products contents) assessed spectrofluorometrically. Concentrations oxidation parameters (total thiols (TTs), protein carbonyls (PCs) (AOPPs) levels) determined spectrophotometrically. Results: We demonstrated that poorly scavenged radicals (hydroxyl radical, nitric oxide, hydrogen peroxide 2,2-diphenyl-1-picrylhydrazyl radical) showed low ferrous ion chelating, unlike aminoguanidine NAC. Sugars/aldehydes caused enhancement parameters, decrease TTs an increase PCs AOPPs levels compared BSA incubated alone. did not reduce baseline significantly exacerbated markers comparison both BSA+glycators. content markedly lower NAC than trazodone. molecular docking revealed its very affinity, which may indicate non-specific binding trazodone, facilitating attachment factors. Conclusion: According our findings, it be concluded counteracts intensifies . A possible mechanism for effect vivo body’s adaptive response, indicated by results review.

Language: Английский

Citations

5
Antioxidant and Anti-Glycation Potential of H2 Receptor Antagonists—In Vitro Studies and a Systematic Literature Review DOI Creative Commons
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1273 - 1273

Published: Sept. 8, 2023

Background: Histamine H2 receptor antagonists are a group of drugs that inhibit gastric juice secretion in gastrointestinal diseases. However, there is evidence to suggest blockers have broader spectrum activity. The antioxidant properties not been fully elucidated, and their anti-glycation potential has studied date. Therefore, this the first study compare antiglycation potentials most popular (ranitidine, cimetidine, famotidine) on protein glycoxidation vitro. Methods: Bovine serum albumin (BSA) was glycated using sugars (glucose, fructose, galactose, ribose) as well aldehydes (glyoxal methylglyoxal). Results: In analyzed drugs, ranitidine only blocker significantly inhibited BSA glycation all tested models. contents carbonyls, products (↓dityrosine, ↓N-formylkynurenine), early (↓Amadori products) late-stage (↓AGEs) decreased samples with addition relative glycating agents. comparable those aminoguanidine Trolox. molecular docking analysis, characterized by lowest binding energy for sites could compete amino groups carbonyl groups. also scavenge free radicals. strongest found ranitidine, which additionally ability bind transition metal ions. systematic literature review revealed effects be attributed its properties. Conclusions: Ranitidine showed Further research needed, particularly patients diseases promote glycation.

Language: Английский

Citations

5