Development and Validation of a Self-Administered Online Hearing Test DOI Creative Commons
Charlotte Vercammen, Olaf Strelcyk

Trends in Hearing, Journal Year: 2025, Volume and Issue: 29

Published: March 1, 2025

We describe the development and validation of a self-administered online hearing test, which screens for loss provides an estimated audiogram. The test computes results from age, self-reported abilities, self-assessed pure-tone thresholds. It relies on regression, Bayesian binary classification, leveraging probabilistic effects age as well interfrequency interaural relationships in audiograms. was devised based data, collected prospectively experiment purposive convenience sample 251 adult American, Australian, Canadian, Swiss participants, 58% whom had loss. Later, we externally validated test. Validation data were representative 156 Belgian 15% Participants completed audiometric assessments at home. primary screening outcome showed that screened mild losses with sensitivity 0.83 [95%-confidence interval (CI): 0.65, 0.96], specificity 0.94 [CI: 0.89, 0.98], positive predictive value 0.70 0.57, 0.87], negative 0.97 0.94, 0.99]. Results secondary audiogram estimation mean differences between gold standard thresholds ranging 2.1 to 12.4 dB, average deviation 14.8 dB. In conclusion, performed comparably state-of-the-art screeners. This therefore, is alternative existing tools, and, additionally, it

Language: Английский

The world report on hearing, 2021 DOI Creative Commons
Shelly Chadha, Kaloyan Kamenov, Alarcos Cieza

et al.

Bulletin of the World Health Organization, Journal Year: 2021, Volume and Issue: 99(4), P. 242 - 242A

Published: March 29, 2021

Language: Английский

Citations

303
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss DOI Creative Commons
Natalia Trpchevska,

Maxim B. Freidin,

Linda Broer

et al.

The American Journal of Human Genetics, Journal Year: 2022, Volume and Issue: 109(6), P. 1077 - 1091

Published: May 16, 2022

Hearing loss is one of the top contributors to years lived with disability and a risk factor for dementia. Molecular evidence on cellular origins hearing in humans growing. Here, we performed genome-wide association meta-analysis clinically diagnosed self-reported impairment 723,266 individuals identified 48 significant loci, 10 which are novel. A large proportion associations comprised missense variants, half lie within known familial loci. We used single-cell RNA-sequencing data from mouse cochlea brain mapped common-variant genomic results spindle, root, basal cells stria vascularis, structure necessary normal hearing. Our findings indicate importance vascularis mechanism impairment, providing future paths developing targets therapeutic intervention loss.

Language: Английский

Citations

46
Adult-onset hearing loss and incident cognitive impairment and dementia – A systematic review and meta-analysis of cohort studies DOI Creative Commons
Ruan‐Ching Yu,

Danielle Proctor,

Janvi Soni

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102346 - 102346

Published: May 23, 2024

We comprehensively summarized the cohort evidence to date on adult-onset hearing loss as risk factor for incident cognitive impairment and dementia, examined dose-response, various dementia subtypes, other moderators. Previous meta-analyses were less comprehensive. included studies with participants without assessments at baseline, minimum 2 years follow-up outcomes. used random-effect models subgroup meta-regression moderator analyses. identified fifty (N=1,548,754). Hearing (yes/no) was associated (HR=1.35 [95% CI = 1.26 – 1.45), mild (MCI HR=1.29 1.11 1.50]), decline not specified MCI or (HR=1.29 1.17 1.42]), Alzheimer's disease (ADD, HR=1.56 1.30 1.87]), but vascular (HR, 0.83 2.05]). Each 10-decibel worsening of a 16% increase in (95% 1.07 1.27). The effect did vary across potential Cohort consistently support that increases decline, MCI, ADD.

Language: Английский

Citations

12
Drug-induced hearing loss: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database DOI

Tingxi Wu,

Zhigang Zhao, Yanchun Wang

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109262 - 109262

Published: April 1, 2025

Language: Английский

Citations

1
The dynamic relationship between hearing loss, quality of life, socioeconomic position and depression and the impact of hearing aids: answers from the English Longitudinal Study of Ageing (ELSA) DOI Creative Commons
Dialechti Tsimpida, Evangelos Kontopantelis, Darren M. Ashcroft

et al.

Social Psychiatry and Psychiatric Epidemiology, Journal Year: 2021, Volume and Issue: 57(2), P. 353 - 362

Published: Aug. 12, 2021

The adverse impact of hearing loss (HL) extends beyond auditory impairment and may affect the individuals' psychosocial wellbeing. We aimed to examine whether there exists a causal pathway between HL depression in later life, via socioeconomic factors quality aids usage alleviates depressive symptoms over time.We examined longitudinal relationship (CES-D) applying dynamic cross-lagged mediation path models. used full dataset participants aged 50-89 years (74,908 person-years), from all eight Waves English Longitudinal Study Ageing (ELSA). Their life (CASP-19) their wealth were as mediator moderator this relationship, respectively. Subgroup analyses investigated differences among those with within different models subjectively objectively identified HL. All adjusted for age, sex, retirement status social engagement.Socioeconomic position (SEP) influenced strength depression, which was stronger lowest versus highest quintiles. use beneficial alleviating symptoms. Those quintiles experienced lower risk after compared quintiles.HL poses substantial older adults, especially who experience inequalities. early detection provision not only promote better-hearing health but could also enhance wellbeing particularly SEP.

Language: Английский

Citations

43
Passive direct methanol fuel cells as a sustainable alternative to batteries in hearing aid devices – An overview DOI Creative Commons
A. Garau, A.M.F.R. Pinto, V.B. Oliveira

et al.

International Journal of Hydrogen Energy, Journal Year: 2022, Volume and Issue: 47(37), P. 16552 - 16567

Published: April 1, 2022

Hearing aids are medical devices used to overcome the deficits associated with hearing loss, commonest sensory disability, which is neither curable nor reversible. The World Health Organization estimates that over 6% of world's population have disabling loss. Therefore, more and hard people benefit from thus, manufactures rely on most recent advances in technology provide advanced features, allowing better communication overall lifestyle aid users society as a whole. These efforts accompanied by both power size considerations, nowadays common options Zn-air battery rechargeable Li-ion Ag–Zn batteries. However, passive direct methanol fuel cell an emergent alternative technology, sustainable source for compact portable electronic applications. This particularly useful developing countries isolated areas where grid recharge batteries unreliable or unavailable, physically economically. paper intends give overview technological issues modern power-up options, their societal impact R&D challenges need pursuit efficient devices. As it discussed, these can market niche innovative deployment commercialization, order respond industry requirements.

Language: Английский

Citations

36
Service delivery approaches related to hearing aids in low- and middle-income countries or resource-limited settings: A systematic scoping review DOI Creative Commons
Lauren K. Dillard, Carolina Der, Ariane Laplante-Lévesque

et al.

PLOS Global Public Health, Journal Year: 2024, Volume and Issue: 4(1), P. e0002823 - e0002823

Published: Jan. 24, 2024

Hearing loss is an important global public health issue which can be alleviated through treatment with hearing aids. However, most people who would benefit from aids do not receive them, in part due to challenges accessing and related services, are salient low- middle-income countries (LMIC) other resource-limited settings. Innovative approaches for aid service delivery overcome many of the access, including that limited human resources trained provide ear care. The purpose this systematic scoping review synthesize evidence on provision LMIC We searched 3 databases (PubMed, Scopus, Ovid MEDLINE) peer-reviewed articles 2000 2022 focused or Fifteen were included, described hospital-based (3 studies), large-scale donation program (1 community-based (7 remote (telehealth; 4 studies) approaches. Key findings services successfully delivered hospital- settings, remotely, both qualified care providers non-specialists quality services. Service care, task sharing among likely improve access worldwide, thereby reducing burden untreated loss.

Language: Английский

Citations

7
Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss DOI Creative Commons
Clara Mendia, Thibault Peineau, Mina Zamani

et al.

Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(3), P. 800 - 817

Published: Jan. 18, 2024

Hearing loss is a major health concern affecting millions of people worldwide with currently limited treatment options. In clarin-2-deficient Clrn2

Language: Английский

Citations

6
Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation DOI
Jun He, Brenda Cabrera‐Mendoza, Flavio De Angelis

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(10), P. 3395 - 3408

Published: March 8, 2024

Abstract Hearing difficulty (HD) is a major health burden in older adults. While ageing-related changes the peripheral auditory system play an important role, genetic variation associated with brain structure and function could also be involved HD predisposition. We analysed large-scale genome-wide association study (GWAS; ntotal = 501 825, 56% females) GWAS data related to 3935 imaging-derived phenotypes (IDPs) assessed up 33 224 individuals (52% using multiple MRI modalities. To investigate pleiotropy function, we conducted correlation, latent causal variable, Mendelian randomization multivariable generalized linear regression analyses. Additionally, performed local correlation multi-trait co-localization analyses identify genomic regions loci implicated pleiotropic mechanisms shared between IDPs. observed widespread of 120 IDPs females, 89 males 171 sex-combined analysis. The variable analysis showed that some these correlations due cause-effect relationships. For seven them, effects were confirmed by approach: vessel volume→HD analysis; hippocampus volume→HD, cerebellum grey matter primary visual cortex HD→fluctuation amplitudes node 46 resting-state functional dimensionality 100 females; global mean thickness→HD HD→mean orientation dispersion index superior corona radiata males. identified 13 signal for rs13026575 variant HD, volume SPTBN1 transcriptomic regulation females. Brain may have role sex differences predisposition via possible relationships regulatory mechanisms.

Language: Английский

Citations

6
Digital Approaches to Automated and Machine Learning Assessments of Hearing: Scoping Review DOI Creative Commons
Jan-Willem A. Wasmann, Leontien Pragt, Robert H. Eikelboom

et al.

Journal of Medical Internet Research, Journal Year: 2021, Volume and Issue: 24(2), P. e32581 - e32581

Published: Dec. 17, 2021

Hearing loss affects 1 in 5 people worldwide and is estimated to affect 4 by 2050. Treatment relies on the accurate diagnosis of hearing loss; however, this first step out reach for >80% those affected. Increasingly automated approaches are being developed self-administered digital assessments without direct involvement professionals.

Language: Английский

Citations

39