Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 26, 2024
Anoikis disrupts the normal apoptotic process in cells, leading to abnormal proliferation and migration, thereby promoting tumor formation development. However, role of anoikis bladder urothelial carcinoma (BLCA) still requires further exploration.
Language: Английский
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(10), P. 5960 - 5976
Published: June 28, 2024
Exosomes are nanoscale membrane bound vesicles secreted by almost all types of cells. Their unique attributes, such as minimal immunogenicity and compatibility with biological systems, make them novel carriers for drug delivery. These native exosomes harbor proteins, nucleic acids, small molecule compounds, fluorogenic agents. Moreover, through a combination chemical bioengineering methodologies, tailored to transport precise therapeutic payloads designated cells or tissues. In this review, we summarize the strategies exosome modification loading modalities in engineered exosomes. addition, provide an overview advances use targeted Lastly, discuss merits limitations chemically versus bioengineered exosome-mediated target therapies. insights offer additional options refining pharmaceutical development hold promise expediting successful translation from bench bedside.
Language: Английский
Citations
7
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104061 - 104061
Published: June 18, 2024
Language: Английский
Citations
6
Published: March 3, 2025
In the clinic, anti-tumor angiogenesis is commonly employed for treating recurrent, metastatic, drug-resistant triple-negative and advanced breast cancer. Our previous research revealed that deubiquitinase STAMBPL1 enhances stability of MKP-1, thereby promoting cisplatin resistance in this study, we discovered could upregulate expression hypoxia-inducible factor HIF1α cancer cells. Therefore, investigated whether promotes tumor angiogenesis. We demonstrated increased HIF1A transcription a non-enzymatic manner, activating HIF1α/VEGFA signaling pathway to facilitate TNBC Through RNA-seq analysis, identified GRHL3 as downstream target responsible mediating transcription. Furthermore, regulates by interacting with FOXO1. These findings shed light on role mechanism pathogenesis cancer, offering novel targets avenues treatment
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 8, 2025
During the process of metastasis, cancer cells transmigrate through endothelial barrier vascular walls. Cancer interact with cells, leading to changes their mechanical properties. While this interaction has been extensively studied from perspective (CCs), properties endothelium remain underexplored, even though they may play a crucial role in regulating process. In study, we used microrheology AFM-based approach demonstrate that (ECs) are altered when cultured either CC-conditioned medium or direct contact cells. We found viscoelasticity ECs decreased diluted medium. Furthermore, cell at short times (less than 30 min) also showed significantly lower stiffness and viscoelastic moduli. parallel, observed reduction quantity actin fibers clusters within EC cytoskeleton, resulting less structured network facilitate CC transmigration. Overall, our findings indicated rheological can be directly physical CCs indirectly via CC-secreted substances. This suggests actively responds presence rather serving only as passive barrier.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 940 - 940
Published: March 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Language: Английский
Citations
0
eLife, Journal Year: 2025, Volume and Issue: 13
Published: April 10, 2025
In the clinic, anti-tumor angiogenesis is commonly employed for treating recurrent, metastatic, drug-resistant triple-negative, and advanced breast cancer. Our previous research revealed that deubiquitinase STAMBPL1 enhances stability of MKP-1, thereby promoting cisplatin resistance in this study, we discovered could upregulate expression hypoxia-inducible factor HIF1α cancer cells. Therefore, investigated whether promotes tumor angiogenesis. We demonstrated increased HIF1A transcription a non-enzymatic manner, activating HIF1α/VEGFA signaling pathway to facilitate triple-negative Through RNA-seq analysis, identified GRHL3 as downstream target responsible mediating transcription. Furthermore, regulates by interacting with FOXO1. These findings shed light on role mechanism pathogenesis cancer, offering novel targets avenues treatment
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189324 - 189324
Published: April 1, 2025
Language: Английский
Citations
0
Journal of the National Cancer Center, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Abstract Cancer remains one of the leading causes death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, incidence certain types cancer persists, urging identification clinically relevant biomarkers development novel therapeutic strategies to improve clinical outcomes overcome treatment resistance. Exosomes, small extracellular vesicles released by diverse cells, have attracted interest biomedical research due their potential as carriers for different treatments. Moreover, exosomes play a pivotal role intercellular communication, modulating various cellular processes. One those is autophagy, pro‐survival pathway that essential human cells. Even though autophagy traditionally described catabolic route, its machinery intricately involved responses, including vesicle formation secretion. In this regard, link between complex, bidirectional, highly dependent on context. Interestingly, both processes been extensively implicated pathogenesis, highlighting targets. This review updates our understanding how can participate progression, with specific focus influence tumor growth, angiogenesis, metastasis. Additionally, interplay these minutely reviewed discussed, we hypothesize crosstalk may hold valuable clues biomarker discovery strategies.
Language: Английский
Citations
0
Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(6), P. 3090 - 3105
Published: June 1, 2024
Exosomes are nanoscale extracellular vesicles secreted by cells, which can release bioactive macromolecules, such as microRNA (miRNA) to receptor cells. efficiently penetrate various biological barriers mediate intercellular communication. MiRNA a class of non-coding RNA that primarily regulate messenger (mRNA) at the post-transcriptional level. is abundant in exosomes, plays an important role being transported and released through exosomes lung cancer This review aims elucidate roles exosome-derived miRNAs cancer.
Language: Английский
Citations
2