Growth Hormone Action as a Target in Cancer: Significance, Mechanisms and Possible Therapies DOI Creative Commons
Reetobrata Basu, César Luiz Boguszewski, John J. Kopchick

et al.

Endocrine Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Growth hormone (GH) is a pituitary derived endocrine required for normal post-natal growth and development. Hypo or hypersecretion of GH results in two pathologic conditions, namely deficiency (GHD) acromegaly. Additionally, also produced non-pituitary tumoral tissues where it acts rather as cellular factor with an autocrine/paracrine mode action. An increasingly persuasive large body evidence over the last 70 years concur that action implicit escalating several cancer-associated events, locally systemically. This pleiotropy GH's effects puzzling, but association cancer-risk automatically raises concern patients acromegaly individuals treated GH. By careful assessment available knowledge on fundamental concepts cancer, suggestions from epidemiological clinical studies, specific reports, this review we aimed to help clarify distinction vs. promoting cancer reconcile discrepancies between experimental data. Along discourse, critically weigh targetability - firstly by detailing molecular mechanisms which posit critical node tumor circuitry, secondly, enumerating currently therapeutic options targeting On basis our discussion, infer targeted intervention appropriate patient population can benefit sizeable subset current prognoses.

Language: Английский

HGH1 Promotes Breast Cancer Progression Through the PI3K/AKT/NF-κB Signaling Pathway: Potential Role for Prognosis and Targeted Therapy DOI Creative Commons
Wenyu Hu,

Daowen Si,

Chenxi Liu

et al.

Breast Cancer Targets and Therapy, Journal Year: 2025, Volume and Issue: Volume 17, P. 325 - 337

Published: April 1, 2025

Previous studies have shown that the HGH1 gene is associated with poor prognosis in a variety of cancers, but its specific function and molecular mechanism pathological process breast cancer remain unclear. The relationship between expression overall survival BC patients was analyzed. Enrichment analysis HGH1-related signaling pathways immune infiltration performed. cell lines overexpression knockdown were constructed to tested proliferation, migration, invasion ability apoptosis. Detected PI3K/AKT pathway cells treated it PI3K inhibitor. effect on vivo observed by tumor xenograft experiment. significantly increased related prognosis. high PI3K-Akt pathway, cycle, senescence, P53 pathway. Overexpression promotes invasion, inhibits apoptosis, while yields opposite effects. promoted growth activating PI3K/AKT/NF-κB use inhibitors could attenuate promoting effect. In experiments confirmed growth. may become new indicator for evaluating serve as potential diagnostic biomarker therapeutic target cancer.

Language: Английский

Citations

0
Conséquences chirurgicales et anatomopathologiques de l’immunothérapie préopératoire en onco-urologie DOI

Youssef Lyoubi,

Sarah Bellal,

Souhil Lebdai

et al.

Bulletin du Cancer, Journal Year: 2024, Volume and Issue: 111(9), P. 822 - 834

Published: May 14, 2024

Language: Английский

Citations

3
HPV, HBV, and HIV-1 Viral Integration Site Mapping: A Streamlined Workflow from NGS to Genomic Insights of Carcinogenesis DOI Open Access
Jane Shen-Gunther,

Acarizia Easley

Published: May 28, 2024

Viral integration within the host genome plays a pivotal role in carcinogenesis. Various disruptive mechanisms are involved, leading to genomic instability, mutations, and DNA damage. With next-generation sequencing (NGS), we can now precisely identify viral breakpoints chimeric sequences, which useful for site analysis. In this study, evaluated commercial hybrid-capture NGS panel specifically designed detecting three key viruses: HPV, HBV, HIV-1. We also tested workflows Hybrid Capture (VHC) Integration Site (VIS) analysis, leveraging customized databases CLC Microbial Ge-nomics. By analyzing sequenced data from virally infected cancer cell lines (including SiHa, HeLa, CaSki, C-33A, DoTc2, 2A3, SCC154 HPV; 3B2, SNU-182 HBV; ACH-2 HIV-1), pinpointed sites. The workflow highlighted disrupted neigh-boring human genes that may play crucial tumor development. Our results included in-formative virus-host read mappings, breakpoints, circular plots. These visual representations enhance our understanding of process. conclusion, seamless end-to-end bridges gap contributions development, paving way improved diagnostics treatment strategies.

Language: Английский

Citations

1
HPV, HBV, and HIV-1 Viral Integration Site Mapping: A Streamlined Workflow from NGS to Genomic Insights of Carcinogenesis DOI Creative Commons
Jane Shen-Gunther,

Acarizia Easley

Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 975 - 975

Published: June 18, 2024

Viral integration within the host genome plays a pivotal role in carcinogenesis. Various disruptive mechanisms are involved, leading to genomic instability, mutations, and DNA damage. With next-generation sequencing (NGS), we can now precisely identify viral breakpoints chimeric sequences, which useful for site analysis. In this study, evaluated commercial hybrid capture NGS panel specifically designed detecting three key viruses: HPV, HBV, HIV-1. We also tested workflows Hybrid Capture (VHC) Integration Site (VIS) analysis, leveraging customized databases CLC Microbial Genomics. By analyzing sequenced data from virally infected cancer cell lines (including SiHa, HeLa, CaSki, C-33A, DoTc2, 2A3, SCC154 HPV; 3B2, SNU-182 HBV; ACH-2 HIV-1), pinpointed sites. The workflow highlighted disrupted neighboring human genes that may play crucial tumor development. Our results included informative virus–host read mappings, breakpoints, circular plots. These visual representations enhance our understanding of process. conclusion, seamless end-to-end bridges gap contributions development, paving way improved diagnostics treatment strategies.

Language: Английский

Citations

1
CDK16 as a potential prognostic biomarker correlated with an immunosuppressive tumor microenvironment and benefits in enhancing the effectiveness of immunotherapy in human cancers DOI Creative Commons

Juntao Qi,

Gujie Wu, Min He

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 22, 2024

Background: Cyclin-Dependent Kinase 16 (CDK16) plays significant biological roles in various diseases. Nonetheless, its function different cancer types and relationship with the Tumor Immune Microenvironment (TIME) are still not well-understood. Methods: We analyzed expression profile, genetic alterations, clinical features, prognostic value of CDK16 pan-cancer using data from The Cancer Genome Atlas, Genotype-Tissue Expression databases, vitro experiments. Additionally, TIMER2 ImmuCellAI databases were utilized to assess correlation between immune cell infiltration levels. Finally, we examined response immunotherapy collected data. Results: is notably overexpressed a risk factor for poor prognosis cancers. Our findings reveal that regulates only cycle-related functions promote proliferation but also autoimmunity-related innate adaptive systems, along other immune-related signaling pathways. Moreover, overexpression contributes an immunosuppressive tumor microenvironment, extensively suppressing features such as genes pathways, well count immune-infiltrating cells. analysis indicated individuals low showed higher rates checkpoint inhibitors longer overall survival compared those high expression. Conclusions: This study establishes potential biomarker predicting wide range Its role shaping microenvironment influencing efficacy highlights urgent need developing targeted therapies against CDK16, offering new avenues treatment management.

Language: Английский

Citations

0
Comprehensive analysis of the prognostic and immunological roles of HGH1 in breast cancer DOI Creative Commons

Qian Ni,

Jinyu Xiang, Jiannan Liu

et al.

Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Language: Английский

Citations

0
The role of HGH1 in breast cancer prognosis: a study on immune response and cell cycle DOI Creative Commons
Hailong Li, Yong Xu, Rong Xu

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 9, 2024

Language: Английский

Citations

0
Growth Hormone Action as a Target in Cancer: Significance, Mechanisms and Possible Therapies DOI Creative Commons
Reetobrata Basu, César Luiz Boguszewski, John J. Kopchick

et al.

Endocrine Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Growth hormone (GH) is a pituitary derived endocrine required for normal post-natal growth and development. Hypo or hypersecretion of GH results in two pathologic conditions, namely deficiency (GHD) acromegaly. Additionally, also produced non-pituitary tumoral tissues where it acts rather as cellular factor with an autocrine/paracrine mode action. An increasingly persuasive large body evidence over the last 70 years concur that action implicit escalating several cancer-associated events, locally systemically. This pleiotropy GH's effects puzzling, but association cancer-risk automatically raises concern patients acromegaly individuals treated GH. By careful assessment available knowledge on fundamental concepts cancer, suggestions from epidemiological clinical studies, specific reports, this review we aimed to help clarify distinction vs. promoting cancer reconcile discrepancies between experimental data. Along discourse, critically weigh targetability - firstly by detailing molecular mechanisms which posit critical node tumor circuitry, secondly, enumerating currently therapeutic options targeting On basis our discussion, infer targeted intervention appropriate patient population can benefit sizeable subset current prognoses.

Language: Английский

Citations

0