Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4273 - 4289
Published: Sept. 1, 2024
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory that lacks effective treatments. Qingchang Wenzhong Decoction (QCWZD) clinically herbal prescription has been proven to attenuate intestinal inflammation in IBD. However, its molecular mechanism of action not clearly elucidated.
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 17, 2024
The intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis prognosis, crucial improving patient outcomes. This comprehensive review synthesizes current findings on microbiome's contribution to CRC pathogenesis, highlighting its potential as a biomarker non-invasive screening strategies. We explore mechanisms through which influences CRC, including roles in inflammation, metabolism, immune response modulation. Furthermore, we assess viability of microbial signatures predictive tools offering insights into personalized treatment approaches. Our analysis underscores necessity advanced metagenomic studies elucidate complex microbiome-CRC nexus, aiming refine diagnostic accuracy prognostic assessment clinical settings. propels forward understanding capabilities, paving way microbiome-based interventions management.
Language: Английский
Citations
7
GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4037 - 4057
Published: June 26, 2024
Oncobiosis has emerged as a key contributor to the development, and modulator of treatment efficacy cancer. Hereby, we review modalities through which oncobiome can support progression tumors, emerging therapeutic opportunities they present. The highlights inherent challenges limitations faced in sampling accurately characterizing oncobiome. Additionally, underscores critical need for standardization microbial analysis techniques consistent reporting microbiome data. We provide suggested metadata set that should accompany datasets from oncological settings so studies remain comparable decipherable.
Language: Английский
Citations
6
International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1839 - 1852
Published: March 1, 2025
Purpose: Bile acids promote the progression of colon adenocarcinoma (COAD), and ursodeoxycholic acid (UDCA) is a key drug in promoting bile excretion, but its role COAD unclear. Our study aims to investigate relationship between metabolism assess feasibility UDCA for treatment COAD. Methods: Firstly, biological targets closely related were identified: Based on cancer genome atlas (TCGA) database, core genes obtained by differential expression analysis weighted gene-coexpression network (WGCNA), subjected gene ontology (GO) function annotation Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis. Secondly, finding target, after identifying as candidate drug, treating was verified reverse: Using databases collect potential UDCA, intersecting exert anti-tumor effects. Then Autodock used molecular docking analyze interaction target proteins. Finally, experimental validation performed: MTT assay, wound healing, transwell migration, angiogenesis assays detect effects cell proliferation, invasion, neovascularization. Results: 2064 screened from TCGA. WGCNA module most relevant CRC, containing 493 genes. KEGG found that overlapping mainly concentrated metabolic pathways. A total 26 5 selected STRING database Cytoscape software: TNF, CYP27B1, MDM2, MMP2, CASP3. Molecular results showed had good binding activity with targets. In vitro experiment effectively inhibited invasion neovascularization cells. Conclusion: The antitumor may be apoptosis, migration vascular neogenesis. Keywords: acid, treatment, metabolism, death
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106516 - 106516
Published: April 1, 2025
Language: Английский
Citations
0
Toxins, Journal Year: 2024, Volume and Issue: 16(9), P. 403 - 403
Published: Sept. 18, 2024
The human colonic commensal enterotoxigenic Bacteroides fragilis (ETBF) is associated with chronic colitis and colon cancer. ETBF colonization induces via the toxin (BFT). BFT secreted by cause inflammation E-cadherin cleavage/NF-κB signaling. promotes tumorigenesis interleukin 17A (IL-17A)/CXCL-dependent inflammation, but its bioactive therapeutics in ETBF-promoted remain unexplored. In current study, we investigated caffeic acid phenethyl ester (CAPE) murine model of tumorigenesis. this observed that CAPE treatment mitigated induced mice. Additionally, our findings indicate offers protective effects against ETBF-enhanced a mouse colitis-associated cancer azoxymethane (AOM) dextran sulfate sodium. Notably, decrease following administration correlates reduction expression IL-17A CXCL1 gastrointestinal tract. molecular mechanism for CAPE-induced protection ETBF-mediated mediated IL-17A/CXCL1, NF-κB activity intestinal epithelial cells. Our may serve as preventive agent development ETBF-induced colorectal (CRC).
Language: Английский
Citations
2
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4273 - 4289
Published: Sept. 1, 2024
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory that lacks effective treatments. Qingchang Wenzhong Decoction (QCWZD) clinically herbal prescription has been proven to attenuate intestinal inflammation in IBD. However, its molecular mechanism of action not clearly elucidated.
Language: Английский
Citations
1