Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 307 - 307

Published: Jan. 29, 2024

In light of the current International Association for Study Pain (IASP) clinical practice guidelines (CPGs) and European Society Medical Oncology (ESMO) guidelines, topic cannabinoids in relation to pain remains controversial, with insufficient research presently available. Cannabinoids are an attractive management option due their synergistic effects when administered opioids, thereby also limiting extent respiratory depression. On own, however, have been shown potential relieve specific subtypes chronic adults, although controversies remain. Among these neuropathic, musculoskeletal, cancer, geriatric pain. Another interesting feature is effectiveness chemotherapy-induced peripheral neuropathy (CIPN). Analgesic benefits hypothesized extend HIV-associated neuropathic pain, as well lower back elderly. The aim this article provide up-to-date review existing preclinical studies, along relevant systematic reviews addressing roles various types settings. impact cancer non-cancer conditions, such multiple sclerosis headaches, all discussed, novel techniques administration mechanisms action.

Language: Английский

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Acute effects of cannabigerol on anxiety, stress, and mood: a double-blind, placebo-controlled, crossover, field trial

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 13, 2024

Abstract Cannabigerol (CBG) is a phytocannabinoid increasing in popularity, with preclinical research indicating it has anxiolytic and antidepressant effects. However, there are no published clinical trials to corroborate these findings humans. The primary objective of this study was examine acute effects CBG on anxiety, stress, mood. Secondary objectives were whether produces subjective drug or motor cognitive impairments. A double-blind, placebo-controlled cross-over field trial conducted 34 healthy adult participants. Participants completed two sessions (with one-week washout period) via Zoom. In each, they provided ratings mood, prior double-blind administration 20 mg hemp-derived placebo tincture (T0). These collected again after participants ingested the product an online survey (T1), Trier Social Stress Test (T2), verbal memory test DRUID impairment app (T3). Relative placebo, significant main effect overall reductions anxiety as well stress at T1. also enhanced relative placebo. There evidence impairment. may represent novel option reduce adults.

Language: Английский

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Effects of magnesium supplementation on muscle soreness in different type of physical activities: a systematic review

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 5, 2024

Magnesium is a micronutrient and an intracellular cation responsible for different biochemical reactions involved in energy production storage, control of neuronal vasomotor activity, cardiac excitability, muscle contraction. deficiency may result impaired physical performance. Moreover, magnesium plays important role on delayed onset soreness after training. Thus, physically active individuals sport specialists have to pay attention supplementation (MgS). However, the type, timing dosage intake are not well elucidated yet. Hence, we aimed systematically review literature regarding effects MgS individuals. We focused exclusively MgS, excluding those studies which was administered together with other substances.

Language: Английский

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Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9407 - 9407

Published: Aug. 29, 2024

Pain is an unpleasant sensory and emotional experience. Adequate pain control often challenging, particularly in patients with chronic pain. Despite advances management, drug addiction, overtreatment, or substance use disorders are not rare. Hence the need for further studies field. The substantial progress made over last decade has revealed genes, signalling pathways, molecules, neuronal networks thus opening new clinical perspectives management. In this respect, data on epigenetic modulation of opioid cannabinoid receptors, key actors pain, offered to preserve activity endocannabinoid systems increase analgesic efficacy opioid- cannabinoid-based drugs. Similarly, upcoming cannabidiol (CBD), a non-psychoactive marijuana plant Cannabis sativa, suggests analgesic, anti-inflammatory, antioxidant, anticonvulsivant ansiolitic effects supports its potential application contexts such as cancer, neurodegeneration, autoimmune diseases but also health fitness athletes. Hence, review article, we summarize emerging modifications receptors focus CBD management practice, health, fitness.

Language: Английский

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An Unexpected Activity of a Minor Cannabinoid: Cannabicyclol (CBL) Is a Potent Positive Allosteric Modulator of Serotonin 5-HT_1A Receptor

Journal of Natural Products, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Cannabicyclol ((±)-CBL), a minor phytocannabinoid, is largely unexplored, with its biological activity previously undocumented. We studied conversion from cannabichromene (CBC) using various acidic catalysts. Montmorillonite (K30) in chloroform at room temperature had the highest yield (60%) minimal byproducts. Key reaction conditions, such as solvent, temperature, and time, significantly impacted yield. The structure of (±)-CBL was confirmed via X-ray crystallography. Stability studies showed that MCT oil dilution remain stable 25–40 °C for three months. Radioligand binding assays revealed high affinity CBL 5-HT1A receptor but weak interaction CB1 CB2 receptors. At 10 μM 1 μM, inhibited [3H]-8-hydroxy-DPAT to by 75% 20%, respectively. Functional acts agonist concentrations potent positive allosteric modulator serotonin-induced activation low concentrations. 4 increased β-arrestin recruitment 20% 80%. This unique modulatory profile highlights potential drug discovery targeting serotonin

Language: Английский

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Cannabinoid Therapy in Athletics: A Review of Current Cannabis Research to Evaluate Potential Real-World Cannabinoid Applications in Sport

Sports Medicine, Journal Year: 2024, Volume and Issue: 54(11), P. 2743 - 2769

Published: Aug. 21, 2024

Language: Английский

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Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical sports applications. It examines their physicochemical properties, anti-inflammatory, analgesic, neuroprotective effects, integration into various hydrogels, sponges, films, scaffolds. also discusses current challenges standardizing formulations, understanding long-term intrinsical regulatory landscapes. Further, it promising applications NPC-loaded materials bone regeneration, wound management, drug delivery systems, emphasizing improved biocompatibility, mechanical therapeutic efficacy demonstrated

Language: Английский

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Nutrological modulation of cannabidiol in the inflammatory processes of athletes: a systematic review

International Journal of Nutrology, Journal Year: 2024, Volume and Issue: 17(S3)

Published: June 13, 2024

Introduction: The correct interaction between the elements of endocannabinoid system plays an important role in development central nervous system. Clinical and preclinical studies suggest that cannabidiol (CBD) may be useful for athletes due to its anti-inflammatory, analgesic, anxiolytic, neuroprotective properties influence on sleep-wake cycle. Furthermore, a series implications epigenetic processes were also proven, through changes expression exosomes microRNAs responsible modulating immune inflammatory systems. Objective: It was list main clinical considerations nutritional modulation immunological systematic review. Methods: PRISMA Platform review rules followed. research carried out from January March 2024 Scopus, PubMed, Science Direct, Scielo, Google Scholar databases. quality based GRADE instrument AMSTAR-2, risk bias analyzed according Cochrane instrument. Results Conclusion: A total 88 articles found. 36 evaluated full 18 included developed present study. Considering tool bias, overall assessment resulted 26 with high 12 did not meet AMSTAR-2. CBD has been reported exert range physiological, biochemical, psychological effects potential benefit human health. For example, there is preliminary supporting evidence CBD's neuroprotective, anxiolytic actions possibility it protect against gastrointestinal damage associated inflammation promote healing traumatic skeletal injuries. combination Δ9-THC can alter activity increasing biosynthesis mediators, leading reduction profile. Despite these findings, still lack randomized and/or prospective controlled robust sample size better understand safety effectiveness use by medium high-performance athletes, as well dosages each type sports performance.

Language: Английский

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Os efeitos do canabidiol na recuperação da dor muscular e na performance após o exercício físico: uma revisão sistemática

Cuadernos de Educación y Desarrollo, Journal Year: 2024, Volume and Issue: 16(12 Edição Especial), P. e6482 - e6482

Published: Dec. 20, 2024

Introdução: Canabidiol (CBD), um composto da planta Cannabis sativa, possui potencial terapêutico, incluindo efeitos anticonvulsivantes e anti-inflamatórios. Recentemente autorizado para atletas pela Agência Mundial Antidoping, esta revisão sistemática investiga os do CBD na recuperação muscular no desempenho após exercícios físicos. Métodos: Seguindo diretrizes PRISMA o Manual Cochrane, incluímos ensaios clínicos randomizados, participantes em físicos, com comparação entre tratamentos sem desfechos relacionados à ou desempenho. Os critérios de exclusão abrangeram estudos envolvendo relatos casos, revisões medidas desfecho. As buscas foram realizadas nas bases dados PubMed, Embase Cochrane Central Register of Controlled Trials. Resultados discussão: Onze incluídos. resultados demonstraram variáveis físico. Alguns sugeriram que pode reduzir danos musculares dor pós-exercício, enquanto outros não encontraram benefícios significativos. Fatores influenciam a eficácia incluem dosagem, momento administração características dos participantes. Considerações finais: evidências indicam inconsistentes. Para estabelecer claras sobre uso contextos esportivos, são necessárias pesquisas adicionais metodologias rigorosas amostras maiores médio longo prazo.

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