The role of sphingosine-1-phosphate in autophagy and related disorders DOI Creative Commons

Siqi Xiao,

Kaixin Peng, C.-L. Li

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Oct. 18, 2023

S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such cell growth, movement, programmed death, self-degradation, specialization, aging, and immune system reactions. Autophagy meticulously controlled mechanism which cells repurpose their elements maintain balance. There are five stages autophagy: initiation, nucleation, elongation maturation, fusion, degradation. New research has provided insight into the complex connection between S1P autophagy, uncovering interaction both normal abnormal circumstances. Gaining knowledge about regulatory of signaling on autophagy can offer valuable understanding its function well-being illness, potentially leading innovative therapeutic concepts for diverse ailments. Hence, this review analyzes essential mammalian specific emphasis recent exploring control each stage by S1P. Additionally, it sheds light roles S1P-induced various disorders.

Language: Английский

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target DOI Creative Commons
Hui Zhao,

Tianqi Ming,

Shun Tang

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: July 14, 2022

Abstract Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but also involved normal physiological processes adults. canonical regulates cell pluripotency determines the differentiation fate cells during development. (also known as Wnt/β-catenin pathway) recognized driver colon cancer one representative pathways. As functional effector molecule signaling, modification degradation β-catenin are key events progression cancer. Therefore, plays an important role pathogenesis diseases, especially colorectal (CRC). Objective Inhibit to explore therapeutic targets Methods Based on studying pathway, master biochemical related analyze relevant when drugs or inhibitors act clarify medication ideas for treatment Results pathways include: planar polarity (Wnt-PCP) Wnt-Ca 2+ pathway. closely proliferation, stemness, apoptosis, autophagy, metabolism, inflammation immunization, microenvironment, resistance, ion channel, heterogeneity, EMT/migration/invasion/metastasis. Drugs/phytochemicals molecular preparations CRC have now been developed. used clinically CRC. Conclusion drugs/phytochemicals targeting can effectively treat clinically.

Language: Английский

Citations

524
The role of lysosomes in metabolic and autoimmune diseases DOI
Frédéric Gros, Sylviane Muller

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(6), P. 366 - 383

Published: March 9, 2023

Language: Английский

Citations

83
Border Control: The Role of the Microbiome in Regulating Epithelial Barrier Function DOI Creative Commons

Fernanda Schreiber,

Iulia Balas,

Matthew J. Robinson

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 477 - 477

Published: March 8, 2024

The gut mucosal epithelium is one of the largest organs in body and plays a critical role regulating crosstalk between resident microbiome host. To this effect, tight control what permitted through barrier high importance. There should be restricted passage harmful microorganisms antigens while at same time allowing absorption nutrients water. An increased permeability, or “leaky gut”, has been associated with variety diseases ranging from infections, metabolic diseases, inflammatory autoimmune to neurological conditions. Several factors can affect including cytokines, dietary components, microbiome. Here, we discuss how impacts permeability epithelial harnessed for therapeutic purposes.

Language: Английский

Citations

25
Epithelial‐immune cell crosstalk for intestinal barrier homeostasis DOI Creative Commons
Yikun Yao, Wanjing Shang, Lingyu Bao

et al.

European Journal of Immunology, Journal Year: 2024, Volume and Issue: 54(6)

Published: March 31, 2024

Abstract The intestinal barrier is mainly formed by a monolayer of epithelial cells, which forms physical to protect the gut tissues from external insults and provides microenvironment for commensal bacteria colonize while ensuring immune tolerance. Moreover, various cells are known significantly contribute function either directly interacting with or producing mediators. Fulfilling this mucosal homeostasis requires not only intrinsic regulation (IECs) but also constant communication microbes. reciprocal interactions between IECs modulate integrity. Dysregulation could lead dysbiosis, inflammation, tumorigenesis. In overview, we provide an update on characteristics functions IECs, how they integrate their tissue microbiota establish homeostasis.

Language: Английский

Citations

25
Mitochondrial function and gastrointestinal diseases DOI

Parsa Haque,

Neeraj Kapur,

Terrence A. Barrett

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(8), P. 537 - 555

Published: May 13, 2024

Language: Английский

Citations

23
Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update DOI Open Access
Sara Jarmakiewicz-Czaja, Magdalena Zielińska, Aneta Sokal

et al.

Genes, Journal Year: 2022, Volume and Issue: 13(12), P. 2388 - 2388

Published: Dec. 16, 2022

Inflammatory bowel disease (IBD) is a chronic with periods of exacerbation and remission the disease. The etiology IBD not fully understood. Many studies point to presence genetic, immunological, environmental, microbiological factors interactions between them in occurrence IBD. review looks at genetic context both predisposition pharmacogenetics.

Language: Английский

Citations

62
The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways DOI Creative Commons

Haoming Luo,

Mingxing Li, Fang Wang

et al.

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(13), P. 5185 - 5206

Published: Jan. 1, 2022

Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via promoting a healthy gut barrier. Within the cell niche, microbiota linking crosstalk of dietary influence and host response has been identified as key regulator ISCs. Emerging insights from recent research reveal that ISC interplay regulates epithelial self-renewal. This article reviews knowledge on their local environment (stem niche) associating with metabolites well signaling pathways. The current progress organoid culture is further summarized. Subsequently, challenges future directions are discussed.

Language: Английский

Citations

42
Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications DOI Creative Commons
Daniel Salete-Granado, Cristina Carbonell, David Puertas-Miranda

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1425 - 1425

Published: July 14, 2023

Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic disease (ALD). Autophagy is a regulated dynamic that sequesters damaged excess cytoplasmic organelles lysosomal degradation may counteract harmful effects ROS-induced stress. These include hepatotoxicity, mitochondrial damage, steatosis, endoplasmic reticulum stress, iron overload. In diseases, particularly ALD, macroautophagy has been implicated as protective mechanism in hepatocytes, although it does not appear play same role stellate cells. Beyond liver, autophagy also mitigate alcohol on other organs, thereby providing an additional layer protection against ALD. potential further supported studies showing drugs interact with autophagy, such rapamycin, can prevent ALD animal models. systematic review presents comprehensive analysis literature, focusing regulation, involvement organ-organ crosstalk relevant autophagy-targeting therapeutic strategies.

Language: Английский

Citations

37
Autophagy in hepatic ischemia–reperfusion injury DOI Creative Commons
Benliang Mao, Wei Yuan, Fan Wu

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: April 5, 2023

Abstract Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver resection or transplantation that can seriously affect patient’s prognosis. There currently no definitive and effective treatment strategy for HIRI. Autophagy an intracellular self-digestion pathway initiated to remove damaged organelles proteins, which maintains cell survival, differentiation, homeostasis. Recent studies have shown autophagy involved in the regulation Numerous drugs treatments change outcome HIRI by controlling pathways autophagy. This review mainly discusses occurrence development autophagy, selection experimental models HIRI, specific regulatory has considerable potential

Language: Английский

Citations

29
Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis DOI Creative Commons
Rasha Abdelhady, Sameh Saber, Mustafa Ahmed Abdel‐Reheim

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 28, 2023

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that demonstrates dramatically increasing incidence worldwide. This study provides novel insights into capacity exogenous β-hydroxybutyrate and ketogenic diet (KD) consumption to alleviate dextran sodium sulfate (DSS)-induced UC in rats. Remarkably, both interventions attenuated activity colon weight-to-length ratio, improved macro microstructures damaged colon. Importantly, KD curbed DSS-induced aberrant NLRP3 inflammasome activation as observed mRNA protein expression analysis. Additionally, inhibition NLRP3/NGSDMD-mediated pyroptosis was detected response regimens. In parallel, these modalities caspase-1 its associated consequences IL-1β IL-18 overproduction. They also mitigated apoptosis indicated by inactivation caspase-3. The anti-inflammatory effects BHB were confirmed reported decline levels markers including MPO, NFκB, IL-6, TNF-α. Moreover, exhibited antioxidative properties reducing ROS production improving enzymes. Their effectiveness mitigating evident renovation normal intestinal epithelial barrier function, shown correcting discrepancies tight junction proteins ZO-1, OCLN, CLDN5. Furthermore, their on microbiota homeostasis investigated. terms autophagy, upregulated BECN-1 downregulated p62, which may account for superiority over attenuating colonic damage. conclusion, this experimental evidence supporting potential therapeutic use or β-hydroxybutyrate-boosting regimens UC.

Language: Английский

Citations

29