Role of autophagy in angiogenic potential of vascular pericytes DOI Creative Commons

Soheil Zamen Milani,

Aysa Rezabakhsh, Mohammad Karimipour

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 6, 2024

The vasculature system is composed of a multiplicity juxtaposed cells to generate functional biological barrier between the blood and tissues. On luminal surface vessels, endothelial (ECs) are in close contact with circulating while supporting basal lamina pericytes wrap abluminal surface. Thus, reciprocal interaction ECs vital element physiological activity vascular system. Several reports have indicated that occurrence pericyte dysfunction under ischemic degenerative conditions results varied micro macro-vascular complications. Emerging evidence points fact autophagy, conserved self-digestive cell machinery, can regulate several like response various stresses pathological conditions. Here, we aim highlight role autophagic angiogenesis potential following different

Language: Английский

Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects DOI Open Access
Xiandeng Li, Ying Zhang, Xiaodong Xing

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115670 - 115670

Published: Oct. 13, 2023

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant challenges in terms early prevention, clinical diagnosis, and treatment. Consequently, it has emerged as major contributor to end-stage renal disease. The glomerular filtration barrier, composed podocytes, endothelial cells, the basement membrane, plays vital role maintaining function. Disruptions podocyte function, including hypertrophy, shedding, reduced density, apoptosis, can impair integrity resulting elevated proteinuria, abnormal rate, increased creatinine levels. Hence, recent research increasingly focused on injury DN, with growing emphasis exploring therapeutic interventions targeting injury. Studies have revealed that factors such lipotoxicity, hemodynamic abnormalities, oxidative stress, mitochondrial dysfunction, impaired autophagy contribute This review aims summarize underlying mechanisms DN provide an overview current status regarding experimental drugs DN. findings presented herein may offer potential targets strategies for management associated

Language: Английский

Citations

44
ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis DOI Creative Commons
Fangquan Chen, Shan Zhu, Rui Kang

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 42(1), P. 111911 - 111911

Published: Dec. 29, 2022

Alkaliptosis, a type of regulated cell death driven by intracellular alkalization, was first described in pancreatic ductal adenocarcinoma (PDAC) cells after treatment with the opioid analgesic drug JTC801. Here, we used mass-spectrometry-based target identification, cellular thermal shift assay, and point mutation technologies to reveal ATP6V0D1 as direct JTC801 that drives alkaliptosis human PDAC cells. Functionally, protein stability ATP6V0D1, when mediated JTC801, increases interaction between STAT3, resulting increased expression activity STAT3 for sustaining lysosome homeostasis. Consequently, pharmacological or genetic inhibition restores sensitivity ATP6V0D1-deficient vitro suitable mouse models. Clinically, high correlates prolonged survival patients PDAC. Together, these results illustrate link advance our understanding targeted therapy.

Language: Английский

Citations

41
Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer/delivery DOI

Kosar Malekpour,

Ali Hazrati, Sara Soudi

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 755 - 769

Published: Jan. 28, 2023

Language: Английский

Citations

39
Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis DOI Creative Commons
Claudia Tanja Mierke

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 184 - 184

Published: Feb. 3, 2024

Tumor diseases become a huge problem when they embark on path that advances to malignancy, such as the process of metastasis. Cancer metastasis has been thoroughly investigated from biological perspective in past, whereas it still less explored physical perspective. Until now, intraluminal pathway cancer received most attention, while interaction cells with macrophages little attention. Apart biochemical characteristics, tumor treatments also rely microenvironment, which is recognized be immunosuppressive and, recently found, mechanically stimulates and thus alters their functions. The review article highlights other vascular metastatic route discusses impact this intercellular interplay mechanical characteristics subsequently functionality cells. For instance, can guide intravascular metastasis, whereby help circumvent adverse conditions within blood or lymphatic vessels. Macrophages induce microchannel tunneling possibly avoid forces during extra- intravasation reduce lumen due flow. key players traditional route. Moreover, effects flows are presented, influences, characterized. Finally, increased knowledge opens up new perspectives for treatment.

Language: Английский

Citations

11
Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives DOI Creative Commons

He-Qin Zhan,

Xiaoxun Zhang, Xu‐Lin Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract Glomerulonephritis (GN) is the most common cause of end-stage renal failure worldwide; in cases, it cannot be cured and can only delay progression disease. At present, main treatment methods include symptomatic therapy, immunosuppressive replacement therapy. However, effective GN hindered by issues such as steroid resistance, serious side effects, low bioavailability, lack precise targeting. With widespread application nanoparticles medical treatment, novel have emerged for kidney diseases. Targeted transportation drugs, nucleic acids, other substances to tissues even cells through nanodrug delivery systems reduce systemic effects adverse reactions drugs improve effectiveness. The high specificity enables them bind ion channels block or enhance channel gating, thus improving inflammation. This review briefly introduces characteristics GN, describes status systematically summarizes research achievements primary diabetic nephropathy lupus nephritis, analyzes recent therapeutic developments, outlines promising directions, gas signaling molecule ultrasmall nanoparticles. current summarized provide a reference better future. Graphical

Language: Английский

Citations

9
Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway DOI

Xiaoyu Zhang,

Yan Lin, Haoran Li

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 228, P. 281 - 298

Published: Jan. 5, 2025

Language: Английский

Citations

1
TNFAIP2 promotes NF-κB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKKβ from ubiquitin proteasome degradation DOI Creative Commons
Xu Teng,

Yaning Wang,

Zechen Zhao

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 13, 2025

Language: Английский

Citations

1
Danshen injection induces autophagy in podocytes to alleviate nephrotic syndrome via the PI3K/AKT/mTOR pathway DOI
Junqi Chen,

Shengliang Yuan,

Jie Zhou

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 107, P. 154477 - 154477

Published: Sept. 25, 2022

Language: Английский

Citations

32
Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy DOI
Xueqi Liu, Ling Jiang,

Han-xu Zeng

et al.

Autophagy, Journal Year: 2023, Volume and Issue: 20(5), P. 1072 - 1097

Published: Dec. 5, 2023

Circular RNAs (circRNAs) are special non-coding RNA (ncRNA) molecules that play a significant role in many diseases. However, the biogenesis and regulation of circRNAs diabetic nephropathy (DN) largely unknown. Here, we investigated expression profile kidney DN mice through circular sequencing (circRNA-seq). The renal biopsy samples patients with had low circ -0,000,953 expression, which was significantly associated function. Furthermore, loss-of-function gain-of-function experiments were carried out to prove DN. Podocyte conditional knockin (cKI) or systemic overexpression alleviated albuminuria restored macroautophagy/autophagy mice. knockdown exacerbated podocyte injury. Mechanistically, found directly binds Mir665-3p-Atg4b perform its Silencing Mir665-3p Atg4b recovered autophagy both vitro vivo. To examine cause downregulation DN, bioinformatics prediction sequence has high possibility containing an m6A methylation site. Additionally, METTL3 proved regulate level YTHDF2 (YTH N6-methyladenosine binding protein 2). In conclusion, this study revealed regulates by targeting Therefore, is potential biomarker for prevention cure

Language: Английский

Citations

20
Tunneling nanotubes: The transport highway for astrocyte-neuron communication in the central nervous system DOI Creative Commons

Cuixiang Zhou,

Min Huang, Shasha Wang

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 209, P. 110921 - 110921

Published: March 4, 2024

Tunneling nanotubes (TNTs) have emerged as pivotal structures for intercellular communication, enabling the transfer of cellular components across distant cells. Their involvement in neurological disorders has attracted considerable scientific interest. This review delineates functions TNTs within central nervous system, examining their role transmission bioenergetic substrates, and signaling molecules, multifaceted impact on both physiological pathological processes, with an emphasis neurodegenerative diseases. The highlights selectivity specificity dedicated pathways cargo delivery, particularly under stress conditions that provoke increased TNT formation. potential therapeutic targets is explored depth. We pay particular attention to interactions between astrocytes neurons mediated by TNTs, which are fundamental brain architecture function. Dysfunctions these implicated spread protein aggregates mitochondrial anomalies, contributing pathogenesis culminates a synthesis current understanding biology identifies research gaps, advocating intensified exploration into promising frontier.

Language: Английский

Citations

6