Unveiling ferroptosis: a new frontier in skin disease research DOI Creative Commons
Ke Wang,

Yumeng Lin,

Dan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

The roles of mitochondria in global and local intracellular calcium signalling DOI
Benjamín Cartes-Saavedra, Arijita Ghosh, György Hajnóczky

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

4
Ferroptosis: a novel mechanism of cell death in ophthalmic conditions DOI Creative Commons
Yaqi Yang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

Citations

5
Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer DOI
Michal Cagalinec, Mohd Adnan, Silvia Borecká

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119954 - 119954

Published: April 1, 2025

Language: Английский

Citations

0
Pathogenetic Involvement of Autophagy and Mitophagy in Primary Progressive Multiple Sclerosis DOI Creative Commons
Simone Patergnani, Michele Laudisi, Massimo Bonora

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(8)

Published: April 1, 2025

ABSTRACT Primary progressive multiple sclerosis (PPMS) affects a subset of MS patients and is characterised by continuous progression from the onset. The molecular mechanisms underlying PPMS are poorly understood, therapeutic options limited, with no specific markers for early detection monitoring. This study investigated roles autophagy mitophagy in PPMS. We found that (ATG5 ATG7) (Parkin Optineurin) were significantly reduced serum compared to control relapsing‐remitting (RRMS) individuals. reduction was associated an increase indicative neurodegeneration mitochondrial dysfunction. Additionally, positive correlation between proteins group suggests these reciprocally modulated Our investigation reveals actively involved exhibit distinct patterns across subtypes. Measurements circulating components related could serve as potential biomarkers detection.

Language: Английский

Citations

0
Mitochondria–membranous organelle contacts at a glance DOI Creative Commons
Antigoni Diokmetzidou, Luca Scorrano

Journal of Cell Science, Journal Year: 2025, Volume and Issue: 138(9)

Published: May 1, 2025

ABSTRACT Mitochondrial contact sites are specialized interfaces where mitochondria physically interact with other organelles. Stabilized by molecular tethers and defined unique proteomic lipidomic profiles, these enable direct interorganellar communication functional coordination, playing crucial roles in cellular physiology homeostasis. Recent advances have expanded our knowledge of site-resident proteins, illuminated the dynamic adaptive nature interfaces, clarified their contribution to pathophysiology. In this Cell Science at a Glance article accompanying poster, we summarize mitochondrial contacts that been characterized mammals, mechanisms underlying formation, principal functions.

Language: Английский

Citations

0
Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate DOI Creative Commons

Haotian Luo,

Hio Cheng Ieong,

Runze Li

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Oct. 22, 2024

Abstract Background Overconsumption of retinoic acid (RA) or its analogues/derivatives has been linked to severe craniomaxillofacial malformations, such as cleft palate and midface hypoplasia. It noted that RA disturbed the proliferation migration embryonic palatal mesenchymal (EPM) cells in these yet exact mechanisms underlying disruptions remained unclear. Methods A model (RA)-induced fetal mice was successfully established. Histological alterations were evaluated using Hematoxylin Eosin (H&E) staining RNA situ hybridization (RNAscope). Cellular levels quantified via Cell Counting Kit-8 (CCK-8) assay EdU incorporation assay, while cell capabilities investigated wound healing Transwell assays. Mitochondrial functions assessed through Mito-Tracker fluorescence, mitochondrial reactive oxygen species (ROS) measurement, ATP level quantification, DNA (mtDNA) copy number analysis. Differential gene expression associated signaling pathways identified bioinformatics Alterations transcriptional translational Lhx6 genes with mitophagy quantitative PCR (qPCR) Western blot analysis, respectively. morphology autophagosomes within examined transmission electron microscopy (TEM). Results Abnormal development mice, along impaired human (HEPM) cells, affecting function concomitant downregulation Lhx6. Knockdown HEPM resulted altered proliferation, migration, function. Conversely, aberrant function, observed RA-induced ameliorated by overexpression Subsequent research demonstrated dysfunction modulating PINK1/Parkin-mediated mitophagy, thereby activating MAPK pathways. Conclusion is essential for homeostasis tuning Downregulation transcriptionally disturbs homeostasis, which turn leads defect ultimately causing palate. Graphical abstract

Language: Английский

Citations

3
A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome DOI Creative Commons
Karan Ahuja,

Marjan Vandenabeele,

Fatemeharefeh Nami

et al.

Acta Neuropathologica Communications, Journal Year: 2024, Volume and Issue: 12(1)

Published: Aug. 28, 2024

Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene. While it categorized as neurodegenerative disease, increasingly becoming clear that other cell types besides neurons may be affected contribute pathogenesis. MRI studies patients phenotyping WS rodent models indicate white matter/myelin loss, implicating role for oligodendroglia WS-associated neurodegeneration. In this study, we sought determine if are whether their dysfunction primary cause of observed optic neuropathy brain We demonstrate 7.5-month-old Wfs1

Language: Английский

Citations

0
Unveiling ferroptosis: a new frontier in skin disease research DOI Creative Commons
Ke Wang,

Yumeng Lin,

Dan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

Citations

0