Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

In Vitro Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes DOI Creative Commons

Islam Alfreahat,

Hamdi Nsairat, Ibrahim Al‐Deeb

et al.

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. This study aimed to evaluate the potentiation of against MCF-7 cancer cell line encapsulating both CAM in PEGylated liposomes. liposomes containing were prepared using thin film hydration method. The physicochemical properties liposomes, average particle size, polydispersity index (PDI), zeta potential, characterized. Encapsulation efficiencies assessed, stability was evaluated over 9 days at room temperature. Cell viability measured an IC50 assay, P-gp expression levels determined ELISA. CAM/DOX-PEGylated exhibited optimal size (238 ± 26.7 nm), PDI (0.29 0.107), potential (-20.9 2.17 mV). These maintained good regarding charge days. 81.05% 78.13% DOX. value 0.13 µM, representing significant reduction compared physical mixture (0.25 µM) free (0.21 cells. ELISA analysis showed approximately 5% with 1.61% results indicate that encapsulated enhances cells, likely inhibition p-glycoprotein. approach may offer promising strategy overcome improve chemotherapy outcomes.

Language: Английский

Citations

2
Advancements of metallic nanoparticles: A promising frontier in cancer treatment DOI Creative Commons
Ali Al‐Samydai, Maha N. Abu Hajleh,

Farah Al-Sahlawi

et al.

Science Progress, Journal Year: 2024, Volume and Issue: 107(4)

Published: Oct. 1, 2024

The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.

Language: Английский

Citations

9
In vivo evaluation of mebendazole and Ran GTPase inhibition in breast cancer model system DOI

Balqis Abu-Hdaib,

Hamdi Nsairat, Mohamed El‐Tanani

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(12), P. 1087 - 1101

Published: April 25, 2024

Aim: To investigate the therapeutic potential of mebendazole (MBZ)-loaded nanostructured lipid carriers (NLCs). Methodology: NLC-MBZ was prepared and characterized to evaluate in vitro vivo anticancer effects inhibitory effect on RanGTP its as an antimetastatic treatment vivo. Results: exhibited a size charge 155 ± 20 nm -27 0.5 mV, respectively, with 90.7% encapsulation. Free MBZ had 50% concentration 610 305 nM, against MDA-MB-231 cell lines. decreased tumor size, suppressed lung metastases, lowered expression CDC25A, SKP2, RbX1 Cullin1 while boosting Rb proteins. Conclusion: displayed antiangiogenic resulted reduced rate metastasis

Language: Английский

Citations

4
Research on an effective, accurate, and universally applicable method for dual-loaded liposomes encapsulation efficiency DOI
Tong Yuan, Yuqi Zhu, Yuting Dai

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Review of recent preclinical and clinical research on ligand-targeted liposomes as delivery systems in triple negative breast cancer therapy DOI

Mohammad Hajimolaali,

Farid Abedin Dorkoosh, Sophia G. Antimisiaris

et al.

Journal of Liposome Research, Journal Year: 2024, Volume and Issue: 34(4), P. 671 - 696

Published: March 23, 2024

Triple-negative breast Cancer (TNBC) is one of the deadliest types, making up about 20% all cancers. Chemotherapy traditional manner progressed TNBC treatment; however, it has a short-term result with high reversibility pace. The lack targeted treatment limited and person-dependent options for those suffering from cautions to be worst type cancer among patients. Consequently, appropriate this disease considered major clinical challenge. Therefore, various methods have been developed treat TNBC, which chemotherapy most common well-known approach recently studied. Although effective are chemotherapies, they often accompanied by critical limitations, especially specific functionality. These lead systematic toxicity and, ultimately, expansion multidrug-resistant (MDR) cells. finding novel efficient techniques enhance targeting an essential requirement. Liposomes demonstrated that method drug delivery; large number liposome-based delivery systems annually developed, small just received authorization application. new approaches using liposomes target their structure ligands increase therapeutic efficiency diminish undesired side effects on body tissues. current study describes recent strategies research associated functionalizing liposomes' different as carriers in treating TNBCs preclinical stages.

Language: Английский

Citations

3
Synthesis, characterization, and applications of starch-based nano drug delivery systems for breast cancer therapy: A review DOI

Shijuan Mei,

R. Roopashree,

Farag M. A. Altalbawy

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 136058 - 136058

Published: Sept. 26, 2024

Language: Английский

Citations

3
Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model DOI Creative Commons

Ruqaya Alhaddad,

Bassam M. Abualsoud, Ibrahim Al‐Deeb

et al.

Future Science OA, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 14, 2024

Methodology: Physical characterization and biological activity were performed against 2D, 3D spheroids MCF-7 cell lines.

Language: Английский

Citations

1