Annals of Noninvasive Electrocardiology,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Jan. 1, 2024
Abstract
Objective
Patients
treated
with
preoperative
chemotherapy
and
immunotherapy
for
bladder
cancer
may
be
at
increased
risk
of
cardiotoxicity
electrophysiological
abnormalities.
This
study
aimed
to
analyze
their
electrocardiographic
(ECG)
alterations.
Methods
who
were
hospitalized
receiving
tislelizumab
plus
nab‐paclitaxel
(TnP)
enrolled
prospectively.
ECG,
cardiac
biomarkers,
echocardiography
performed
baseline
the
end
TnP.
Results
A
total
60
patients
(76.7%
males),
including
30
muscle‐invasive
non‐muscle‐invasive
cancer,
received
three
or
four
cycles
TnP,
respectively.
Hypertension
was
commonest
comorbidity
(41.7%),
25
(41.7%)
prescribed
cardiovascular
drugs.
In
comparison
characteristics,
troponin
I
(cTnI)
N‐terminal
pro‐brain
natriuretic
peptide
(NT‐proBNP)
within
normal
ranges
after
However,
echocardiographic
parameter
left
ventricular
ejection
fraction
slightly
decreased
TnP
(62.81
±
3.81%
61.10
4.37%,
p
=
.011).
The
incidence
abnormal
ECG
from
65.0%
76.7%,
which
only
a
higher
prevalence
fragmented
QRS
(fQRS)
observed
(33.3%
50.0%,
.013;
mainly
in
inferior
leads).
parameters
QT
dispersion
(QTd)
prolonged
significantly
regimen
(39.50
11.37
44.20
15.85
ms,
.019).
Conclusion
combined
immunotherapy,
main
abnormality
fQRS
QTd,
relatively
biomarkers
parameters.
Regular
screening
should
carried
out
carefully
detect
potential
long‐term
follow‐up.
Physiology,
Journal Year:
2023,
Volume and Issue:
39(2), P. 98 - 125
Published: Dec. 5, 2023
The
heart,
once
considered
a
mere
blood
pump,
is
now
recognized
as
multifunctional
metabolic
and
endocrine
organ.
Its
function
tightly
regulated
by
various
processes,
at
the
same
time
it
serves
an
organ,
secreting
bioactive
molecules
that
impact
systemic
metabolism.
In
recent
years,
research
has
shed
light
on
intricate
interplay
between
heart
other
organs,
such
adipose
tissue,
liver,
skeletal
muscle.
flexibility
of
its
ability
to
switch
different
energy
substrates
play
crucial
role
in
maintaining
cardiac
overall
homeostasis.
Gaining
comprehensive
understanding
how
disorders
disrupt
metabolism
crucial,
plays
pivotal
development
progression
diseases.
emerging
organ
highlights
essential
contribution
whole
body
regulation
offers
new
insights
into
pathogenesis
diseases,
obesity,
diabetes,
cardiovascular
disorders.
this
review,
we
provide
in-depth
exploration
heart's
functions,
emphasizing
organs.
Furthermore,
evidence
suggests
correlation
disease
conditions
aging
cancer,
indicating
dysfunction
observed
these
may
share
common
underlying
mechanisms.
By
unraveling
complex
mechanisms
metabolism,
aim
contribute
novel
therapeutic
strategies
for
diseases
improve
health.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13104 - 13104
Published: Aug. 23, 2023
HIV-1
has
evolved
a
plethora
of
strategies
to
overcome
the
cytoskeletal
barrier
(i.e.,
actin
and
intermediate
filaments
(AFs
IFs)
microtubules
(MTs))
achieve
viral
cycle.
modifies
organization
dynamics
by
acting
on
associated
adaptors
molecular
motors
productively
fuse,
enter,
infect
cells
then
traffic
cell
surface,
where
virions
assemble
are
released
spread
infection.
The
envelope
(Env)
initiates
cycle
binding
signaling
through
its
main
surface
receptors
(CD4/CCR5/CXCR4)
shape
cytoskeleton
for
fusion
pore
formation,
which
permits
core
entry.
Then,
capsid
is
transported
nucleus
with
tracks
under
control
specific
adaptors/molecular
motors,
as
well
accessory
proteins.
Furthermore,
drives
late
stages
regulating
assure
Pr55Gag
expression
transport
it
assembles
buds
mature
infectious
virions.
In
this
review,
we
therefore
analyze
how
generates
cell-permissive
state
infection
factors.
Likewise,
discuss
relevance
knowledge
understand
pathogenesis
in
patients
develop
therapeutic
battle
HIV-1.
Cancer Medicine,
Journal Year:
2023,
Volume and Issue:
12(13), P. 13873 - 13884
Published: April 5, 2023
Abstract
Objectives
Anaplastic
lymphoma
kinase
tyrosine
inhibitors
(ALK
TKIs)
have
shown
remarkable
clinical
activity
in
patients
with
non‐small‐cell
lung
cancer
(NSCLC).
However,
pneumonitis
is
a
serious
side
effect
of
ALK
TKIs
NSCLC
patients.
In
this
meta‐analysis,
we
aimed
to
determine
the
incidence
ALK‐TKI‐associated
pneumonitis.
Materials
and
Methods
We
searched
electronic
databases
identify
relevant
studies
published
until
August
2022.
The
was
calculated
using
fixed‐effects
model
when
no
substantial
heterogeneity
observed.
Otherwise,
random‐effects
used.
Subgroup
analyses
different
treatment
groups
were
performed.
Statistical
conducted
STATA
17.0.
Results
Twenty‐six
trials
involving
4752
eligible
for
analysis.
All‐grade
2.92%
(95%
confidence
interval
[CI]:
1.79%–4.27%),
high‐grade
(Grade
3–4)
1.42%
CI:
0.84%–2.12%)
Grade
5
0.09%
0.00%–0.28%).
subgroup
analysis
showed
that
brigatinib
associated
highest
both
all‐grade
(7.09%
3.06%,
respectively).
TKI
after
chemotherapy
higher
than
first‐line
(7.73%
vs.
2.26%
3.64%
1.26%,
Cohorts
from
Japanese
had
Conclusion
Our
study
provides
precise
data
on
receiving
TKIs.
Overall,
tolerable
pulmonary
toxicity.
Early
identification
are
required
prevent
further
deterioration
those
who
received
prior
chemotherapy,
particularly
population.
The
incidence
of
gastrointestinal
cancers
has
seen
a
significant
increase
in
recent
years.
Current
treatments
present
numerous
challenges,
including
drug
resistance,
non-specificity,
and
severe
side
effects,
among
others.
These
issues
have
necessitated
the
exploration
new
therapeutic
strategies.
One
promising
avenue
is
use
magnetic
nanoparticles,
which
gained
considerable
interest
due
to
their
ability
generate
heat
tumor
regions
upon
application
an
external
alternating
field,
process
known
as
hyperthermia.
This
review
conducted
systematic
search
vitro
vivo
studies
published
last
decade
that
employ
hyperthermia
therapy
mediated
by
nanoparticles
for
treating
cancers.
After
applying
various
inclusion
exclusion
criteria,
total
40
articles
were
analyzed.
results
revealed
iron
oxide
preferred
material
magnetism
generation
colorectal
cancer
most
studied
cancer.
Interestingly,
novel
therapies
employing
loaded
with
chemotherapeutic
drugs
demonstrated
excellent
antitumor
effect.
In
conclusion,
appear
be
effective
approach
treatment
cancers,
offering
advantages
over
traditional
therapies.
Annals of Noninvasive Electrocardiology,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Jan. 1, 2024
Abstract
Objective
Patients
treated
with
preoperative
chemotherapy
and
immunotherapy
for
bladder
cancer
may
be
at
increased
risk
of
cardiotoxicity
electrophysiological
abnormalities.
This
study
aimed
to
analyze
their
electrocardiographic
(ECG)
alterations.
Methods
who
were
hospitalized
receiving
tislelizumab
plus
nab‐paclitaxel
(TnP)
enrolled
prospectively.
ECG,
cardiac
biomarkers,
echocardiography
performed
baseline
the
end
TnP.
Results
A
total
60
patients
(76.7%
males),
including
30
muscle‐invasive
non‐muscle‐invasive
cancer,
received
three
or
four
cycles
TnP,
respectively.
Hypertension
was
commonest
comorbidity
(41.7%),
25
(41.7%)
prescribed
cardiovascular
drugs.
In
comparison
characteristics,
troponin
I
(cTnI)
N‐terminal
pro‐brain
natriuretic
peptide
(NT‐proBNP)
within
normal
ranges
after
However,
echocardiographic
parameter
left
ventricular
ejection
fraction
slightly
decreased
TnP
(62.81
±
3.81%
61.10
4.37%,
p
=
.011).
The
incidence
abnormal
ECG
from
65.0%
76.7%,
which
only
a
higher
prevalence
fragmented
QRS
(fQRS)
observed
(33.3%
50.0%,
.013;
mainly
in
inferior
leads).
parameters
QT
dispersion
(QTd)
prolonged
significantly
regimen
(39.50
11.37
44.20
15.85
ms,
.019).
Conclusion
combined
immunotherapy,
main
abnormality
fQRS
QTd,
relatively
biomarkers
parameters.
Regular
screening
should
carried
out
carefully
detect
potential
long‐term
follow‐up.
