Plant-Mediated Inorganic Nanoparticles for Anti-Tumor Therapy in Colorectal Cancer: A Systematic Review DOI Creative Commons
Cristina Mesas, Francisco Quiñonero,

Francisco Revueltas

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(18), P. 10156 - 10156

Published: Sept. 9, 2023

Colon cancer is the third most frequent neoplasm and second lethal worldwide. Despite progress in its treatment, new therapies are still needed to improve prognosis of this type tumor and, context, use plant compounds with anti-tumor properties has been increasing recent years. The aim systematic review was analyze potential benefits encapsulation derived from extracts nanoparticles their cytotoxic effect under vitro conditions. Once search strategy defined based on selected MESH terms, 147 publications published since 2012 were identified three different databases (PubMed, SCOPUS WOS). After eliminating duplicates applying inclusion exclusion criteria, 17 studies finally included. results showed that natural encapsulated offered significant activity against colon neoplastic cells by therapeutic free through without producing toxicity healthy cells. In addition, (14) involved metal-derived (zinc, iron gold). possible efficacy these nanodrugs, more vivo elucidate future application biocompatibility.

Language: Английский

Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer DOI Open Access
Vanessa-Meletia Bala, Dimitra Ioanna Lampropoulou,

STAMATIKI GRAMMATIKAKI

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 296 - 296

Published: Dec. 25, 2023

Hyperthermia has the potential to damage cancerous tissue by increasing body temperature. However, targeting cancer cells whilst protecting surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that combination of nanotechnology and hyperthermia offers more successful penetration nanoparticles tumor environment, thus allowing targeted region interest. At same time, unlike radiotherapy, use non-ionizing radiation makes an attractive therapeutic option. This review summarizes existing literature regarding cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.

Language: Английский

Citations

16
Nanomedicine and Hyperthermia for the Treatment of Gastrointestinal Cancer: A Systematic Review DOI Open Access
Lidia Gago, Francisco Quiñonero, Gloria Perazzoli

et al.

Published: June 13, 2023

The incidence of gastrointestinal cancers has seen a significant increase in recent years. Current treatments present numerous challenges, including drug resistance, non-specificity, and severe side effects, among others. These issues have necessitated the exploration new therapeutic strategies. One promising avenue is use magnetic nanoparticles, which gained considerable interest due to their ability generate heat tumor regions upon application an external alternating field, process known as hyperthermia. This review conducted systematic search vitro vivo studies published last decade that employ hyperthermia therapy mediated by nanoparticles for treating cancers. After applying various inclusion exclusion criteria, total 40 articles were analyzed. results revealed iron oxide preferred material magnetism generation colorectal cancer most studied cancer. Interestingly, novel therapies employing loaded with chemotherapeutic drugs demonstrated excellent antitumor effect. In conclusion, appear be effective approach treatment cancers, offering advantages over traditional therapies.

Language: Английский

Citations

4
PLA-HA/Fe3O4 magnetic nanoparticles loaded with Curcumin: Physicochemical characterization and toxicity evaluation in HCT116 Colorectal cancer cells DOI Creative Commons
Shima Bourang,

Sina Asadian,

Mehran Noruzpour

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 11, 2024

Abstract Colorectal cancer (CRC) is the third most common, harmful, and universal second lethal type. This paper discusses therapeutic potential of curcumin, a major curcuminoid found in substructure plant Curcuma longa (turmeric), against CRC. Curcumin has ability to disrupt variety cellular signaling pathways been validated several preclinical clinical studies, but suffers from low solubility bioavailability. To address these issues, PLA-HA/Fe 3 O4 magnetic nanoparticles were synthesized loaded with curcumin. The average size zeta properties measured. drug encapsulation efficiency cumulative release curcumin under acidic neutral pH values evaluated, as well cytotoxic effect on HCT116 colorectal cells. results demonstrated that have high degree biocompatibility carry medications. cells 200 µg/ml O 4 /Curcumin 58.63 ± 3.7% percent cell viability. Ultimately, PLA-HA, Fe , Curcumin's physicochemical characteristics impact viability render them valuable instruments for precisely delivering drugs -curcumin well-targeted delivery system upcoming treatments, evidenced by their overall strong effects negligible toxicity towards non-cancerous

Language: Английский

Citations

1
Plant-Mediated Inorganic Nanoparticles for Anti-Tumor Therapy in Colorectal Cancer: A Systematic Review DOI Creative Commons
Cristina Mesas, Francisco Quiñonero,

Francisco Revueltas

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(18), P. 10156 - 10156

Published: Sept. 9, 2023

Colon cancer is the third most frequent neoplasm and second lethal worldwide. Despite progress in its treatment, new therapies are still needed to improve prognosis of this type tumor and, context, use plant compounds with anti-tumor properties has been increasing recent years. The aim systematic review was analyze potential benefits encapsulation derived from extracts nanoparticles their cytotoxic effect under vitro conditions. Once search strategy defined based on selected MESH terms, 147 publications published since 2012 were identified three different databases (PubMed, SCOPUS WOS). After eliminating duplicates applying inclusion exclusion criteria, 17 studies finally included. results showed that natural encapsulated offered significant activity against colon neoplastic cells by therapeutic free through without producing toxicity healthy cells. In addition, (14) involved metal-derived (zinc, iron gold). possible efficacy these nanodrugs, more vivo elucidate future application biocompatibility.

Language: Английский

Citations

3