Organ-on-a-Chip Applications in Microfluidic Platforms

Micromachines, Journal Year: 2025, Volume and Issue: 16(2), P. 201 - 201

Published: Feb. 10, 2025

Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research drug discovery. This article reviews the design fabrication of microfluidic devices. It also explores how these technologies are integrated into OoC platforms to simulate environments, highlighting key principles, technological advances, diverse applications. Through case studies involving simulation multiple organs such as heart, liver, lungs, evaluates impact systems' on screening, toxicity assessment, personalized medicine. In addition, this considers technical challenges, ethical issues, future directions, looks ahead further optimizing functionality biomimetic precision OoCs through innovation, emphasizing its critical promoting medicine treatment strategies.

Language: Английский

Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses advancements in organ-on-a-chip models, emphasizing gut, liver, and integrated gut–liver systems. It covers their applications disease modeling, toxicity testing, drug screening, as well future prospects.

Language: Английский

Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский