Threats to social safety and neuro-inflammatory mechanisms underlying sexual orientation disparities in depression symptom severity: A prospective cohort study of young adults DOI Creative Commons
Richard Bränström, Mark L. Hatzenbuehler, Micah R. Lattanner

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 211 - 219

Published: March 27, 2024

Sexual minority individuals have a markedly elevated risk of depression compared to heterosexuals. We examined early threats social safety and chronically inflammation as mechanisms contributing this disparity in symptoms, the relative strength co-occurrence between chronic symptoms for sexual minorities versus To do so, we analyzed data from prospective cohort heterosexual young adults (n = 595), recruited nationally representative sample, that included assessments form adverse childhood interpersonal events, three biomarkers (i.e., CRP, IL-6, TNF-α) measured at two time points, over four years. In pre-registered analyses, found experienced more were likely display inflammation, reported severe than Adverse events explained approximately 23 % total effect association orientation symptom severity. Further, there was an increased coupling among These results provide novel longitudinal, population-based evidence role linking during with severity adulthood, consistent primary tenets signal transduction theory depression. Our study extends population level by finding members stigmatized minorities) experience greater because their exposure subsequent link highlighting potential biopsychosocial intervention targets.

Language: Английский

Multi-omics in stress and health research: study designs that will drive the field forward DOI Creative Commons
Summer Mengelkoch, Jeffrey Gassen, Shahar Lev‐Ari

et al.

Stress, Journal Year: 2024, Volume and Issue: 27(1)

Published: Feb. 29, 2024

Despite decades of stress research, there still exist substantial gaps in our understanding how social, environmental, and biological factors interact combine with developmental stressor exposures, cognitive appraisals stressors, psychosocial coping processes to shape individuals' reactivity, health, disease risk. Relatively new profiling approaches, called multi-omics, are helping address these issues by enabling researchers quantify thousands molecules from a single blood or tissue sample, thus providing panoramic snapshot the molecular occurring an organism systems perspective. In this review, we summarize two types research designs for which multi-omics approaches best suited, describe can help advance development, prevention, treatment stress-related pathologies. We first discuss incorporating into theory-rich, intensive longitudinal study characterize, high-resolution, transition multisystem dysfunction throughout development. Next, should be incorporated intervention better understand back inform novel precision medicine managing fostering biopsychosocial resilience. Throughout, provide concrete recommendations studies that will translate data health care.

Language: Английский

Citations

11
A systematic review of associations between emotion regulation characteristics and inflammation DOI
Daniel P. Moriarity,

Mora M. Grehl,

Rachel F.L. Walsh

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105162 - 105162

Published: April 5, 2023

Language: Английский

Citations

19
The future is dynamic: A call for intensive longitudinal data in immunopsychiatry DOI Creative Commons
Daniel P. Moriarity, George M. Slavich

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 112, P. 118 - 124

Published: June 5, 2023

The long-term value of immunopsychiatry will be based on its ability to translate basic science into effective clinical interventions. In this article, we discuss a key obstacle achieving important translational goal-namely, the preponderance studies that are cross-sectional, or have months-to-years long follow-up periods. Immunopsychiatric processes such as stress, inflammation, and depression symptoms inherently dynamic fluctuate over hours, days, weeks. This fact suggests higher-density data collection with only days between measurements is necessary capture-with adequate resolution-the actual dynamics these systems, determine optimal time lags which observe associations variables interest, maximize potential data. To illustrate points, use pilot from our own intensive longitudinal immunopsychiatric study. We then conclude by making several recommendations for future research. By learning how better existing dynamically informative well collecting data, believe much positioned advance causal understanding interplay immune system health.

Language: Английский

Citations

18
Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations DOI Open Access
Summer Mengelkoch, Sophia Miryam Schüssler‐Fiorenza Rose, Ziv Lautman

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 114, P. 475 - 487

Published: Aug. 4, 2023

Language: Английский

Citations

18
The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology DOI Creative Commons
Rachel Gilgoff, Summer Mengelkoch, Jorina Elbers

et al.

Stress, Journal Year: 2024, Volume and Issue: 27(1)

Published: May 6, 2024

Although dysregulated stress biology is becoming increasingly recognized as a key driver of lifelong disparities in chronic disease, we presently have no validated biomarkers toxic physiology; biological, behavioral, or cognitive treatments specifically focused on normalizing processes; and agreed-upon guidelines for treating the clinic evaluating efficacy interventions that seek to reduce improve human functioning. We address these critical issues by (a) systematically describing systems mechanisms are stress; (b) summarizing indicators, biomarkers, instruments assessing response systems; (c) highlighting therapeutic approaches can be used normalize stress-related biopsychosocial also present novel multidisciplinary Stress Phenotyping Framework bring researchers clinicians one step closer realizing goal using precision medicine-based prevent treat stress-associated health problems.

Language: Английский

Citations

6
Affirmative Mindfulness, Acceptance, and Compassion-Based Group Intervention for Sexual Minorities (Free2Be): A Non-Randomized Mixed-Method Study for Feasibility with Exploratory Analysis of Effectiveness DOI Creative Commons
Daniel Seabra, Jorge Gato, Nicola Petrocchi

et al.

Mindfulness, Journal Year: 2024, Volume and Issue: 15(7), P. 1814 - 1830

Published: July 1, 2024

Abstract Objectives Despite sexual minority (SM), i.e. individuals who identify as lesbian women, gay men, bisexual, or pansexual, presenting worse mental health outcomes when compared to heterosexual individuals, they face more difficulties in accessing affirmative and quality services. This study is a mixed-method non-randomized single-arm trial targeting SM assessing the feasibility exploratory findings from an mindfulness, acceptance, compassion-based group intervention ( Free2Be ). Method Eighteen participants self-identified SM, with mean age of 30.80 years old, underwent face-to-face 13 weekly sessions Feasibility was assessed three domains (acceptability, practicality, preliminary effectiveness) self-report questionnaires hetero-report interviews, during after intervention, using mixed-methods approach. Using pre–post participant-by-participant design, changes were self-reported internalized stigma, psychopathology indicators, compassion processes. Results The acceptable feasible all domains. Participants completed (≥ 80% attendance) revealed significant reliable decreases stress social anxiety symptoms, self-criticism, fear for self. Conclusions provides evidence intervention. seems be individuals. These promising warrant further investigation within pilot study.

Language: Английский

Citations

6
Bullying fosters interpersonal distrust and degrades adolescent mental health as predicted by Social Safety Theory DOI
Dimitris I. Tsomokos, George M. Slavich

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(3), P. 328 - 336

Published: Feb. 13, 2024

Language: Английский

Citations

5
The effects of childhood adversity on twenty-five disease biomarkers and twenty health conditions in adulthood: Differences by sex and stressor type DOI Creative Commons
Jenna Alley, Jeffrey Gassen, George M. Slavich

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 164 - 176

Published: July 25, 2024

Although early adversity is now recognized as a major public health concern, it remains unclear if the effects of early-life stressors on disease biology and differ by sex or stressor type. Because childhood often covary, examining whether such typically occur together (e.g., cumulative adversity) in distinct multivariate patterns needed to determine how different life uniquely affect health. To investigate, we conducted latent class analyses (LCA) identify clusters adults experiencing multiple (N=2,111, Mage = 53.04, 54.8 % female) Midlife United States (MIDUS) Study. We then tested exposure groups, individual stressors, related 25 biomarkers inflammation, metabolism, stress, 20 conditions. Multivariate effect sizes were estimated using Mahalanobis's D. Optimal LCA models yielded three female (Low-, Moderate-, High-Stress) two male (Low- classes. The High-Stress classes had greater inflammation (male: D=0.43; female: D=0.59) poorer metabolic D=0.32–0.33; D=0.32–0.47). They also more cardiovascular HR=1.56 [1.17, 2.07]; HR=1.97 [1.50, 2.58]), cancer HR=2.41 [1.52, 3.84]; HR=2.51 [1.45, 4.35]), HR=1.54 [1.16, 2.03]; HR=2.01 [1.43, 2.83]), thyroid HR=3.65 [1.87, 7.12]; HR=2.25 [1.36, 3.74]), arthritis HR=1.81 [1.30, 2.54]; [1.41, 2.74]), mental/behavioral problems HR=2.62 [1.90, 3.62]; female; HR=3.67 [2.72, 4.94]). Moreover, these outcomes sex- stressor-specific manner. Childhood portends worse biological elevated risk for many These findings advance stress theory may help inform precision interventions managing stress.

Language: Английский

Citations

5
(Self)tainted love: Shame and self-criticism as self-discriminatory processes underlying psychological suffering in sexual minority individuals DOI
Daniel Seabra, Sérgio A. Carvalho, Jorge Gato

et al.

Journal of Human Behavior in the Social Environment, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: March 22, 2024

Sexual Minoritized (SM) people are reported to experience higher levels of psychopathology when compared heterosexual individuals. Minority Stress Theory and Psychological Mediation Framework suggest that exposure minority stress is responsible for this disparity. Shame also a known risk factor psychopathology. This study aims test the indirect effect discrimination on through internalized stigma, shame, self-criticism, in sample 372 SM adults. All variables were significantly correlated with each other, except stigma discrimination, anxiety, social anxiety. Internalized did not exert significant between self-criticism sole underlying processes mediating relationship

Language: Английский

Citations

4
A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study DOI Creative Commons
Catherine Kelly, Caroline Trumpff,

Carlos Alberto Palacio Acosta

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(10), P. 884 - 901

Published: Oct. 1, 2024

Language: Английский

Citations

4