Cited by Real-life experience on the use of isavuconazole in solid organ transplantation

Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease DOI

Martin Hoenigl, Amir Arastehfar, Maiken Cavling Arendrup

et al.

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(2)

Published: April 11, 2024

SUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, their utility efficacy in antifungal treatment limited one or more of innate acquired resistance some fungi, poor penetration into "sequestered" sites, agent-specific side effect which require frequent patient reassessment monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, fungicidal mechanism(s) urgently needed. Here, we provide comprehensive review agents, both improved known mechanisms actions new currently clinical development for treating invasive yeast, mold (filamentous fungi),

Language: Английский

Citations

S1-Leitlinie: Diagnostik und Therapie der invasiven pulmonalen Aspergillose bei kritisch kranken/intensivpflichtigen Patienten DOI

Dominic Wichmann,