Molecular Approaches to Treating Chronic Obstructive Pulmonary Disease: Current Perspectives and Future Directions DOI Open Access
S. K. Vu, Kaleb Veit, Ruxana T. Sadikot

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2184 - 2184

Published: Feb. 28, 2025

Chronic obstructive pulmonary disease (COPD) is a clinical syndrome that presents as airflow limitation with poor reversibility accompanied by dynamic hyperinflation of the lung. It complex chronic inflammatory airway changes caused exposure to noxious particles or gases, such cigarette smoke. The involves persistent inflammation and oxidative stress, perpetuated frequent exacerbations. prevalence COPD on rise, prediction it will be leading cause morbidity mortality over next decade. Despite global burden its associated mortality, treatment remains limited. Although understanding pathogenesis has increased last two decades, molecular approaches develop new therapies for have lagged. Here, we review potential developing novel COPD.

Language: Английский

Animal models of chronic obstructive pulmonary disease and their role in drug discovery and development: a critical review DOI
Maria Gabriella Matera, Luigino Calzetta, Barbara Rinaldi

et al.

Expert Opinion on Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Introduction To understand the mechanisms of COPD and to discover test new drugs, laboratory animals are essential. However, complex changes associated with disease in humans difficult fully replicate animal models.

Language: Английский

Citations

0
Molecular Approaches to Treating Chronic Obstructive Pulmonary Disease: Current Perspectives and Future Directions DOI Open Access
S. K. Vu, Kaleb Veit, Ruxana T. Sadikot

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2184 - 2184

Published: Feb. 28, 2025

Chronic obstructive pulmonary disease (COPD) is a clinical syndrome that presents as airflow limitation with poor reversibility accompanied by dynamic hyperinflation of the lung. It complex chronic inflammatory airway changes caused exposure to noxious particles or gases, such cigarette smoke. The involves persistent inflammation and oxidative stress, perpetuated frequent exacerbations. prevalence COPD on rise, prediction it will be leading cause morbidity mortality over next decade. Despite global burden its associated mortality, treatment remains limited. Although understanding pathogenesis has increased last two decades, molecular approaches develop new therapies for have lagged. Here, we review potential developing novel COPD.

Language: Английский

Citations

0