Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a cis-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors
Hany M. Abd El‐Lateef,
No information about this author
Ahmed Gaafar Ahmed Gaafar,
No information about this author
Arwa Sultan Alqahtani
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et al.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(34), P. 24781 - 24790
Published: Jan. 1, 2024
A
set
of
novel
quinoline
tethered
cis
-vinyl
triamides
derivatives
has
been
designed,
synthesized
and
screened
for
in
vitro
cytotoxicity
against
the
MCF-7
breast
adenocarcinoma
cell
line.
Language: Английский
Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(32), P. 23495 - 23504
Published: Jan. 1, 2024
A
sequence
of
novel
2-(quinoline-4-carbonyl)hydrazide
scaffolds
carrying
the
acrylamide
moiety
have
been
synthesized
and
evaluated
for
in
vitro
cytotoxicity
against
an
MCF-7
breast
cancer
cell
line.
Language: Английский
Exploring the antitumor potential of novel quinoline derivatives via tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking
Heba Abdelmegeed,
No information about this author
Lina M. A. Abdel Ghany,
No information about this author
Amira Youssef
No information about this author
et al.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(31), P. 22092 - 22112
Published: Jan. 1, 2024
A
series
of
quinoline
derivatives
was
designed
and
synthesized
as
novel
tubulin
inhibitors
targeting
the
colchicine
binding
site.
Language: Английский
Novel Quinolin-4-ylcarbonylhydrazine Having N-(3-Arylacryloyl) Moiety: Design, Synthesis and Biological Evaluation as Potential Cytotoxic Agents against MDA-MB-231 via Tubulin Assembly Inhibition
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
1321, P. 140214 - 140214
Published: Sept. 27, 2024
Language: Английский
Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(46), P. 34005 - 34026
Published: Jan. 1, 2024
Cancer
is
the
second
leading
cause
of
death
globally,
surpassed
only
by
heart
disease.
Moreover,
bacterial
infections
remain
a
significant
global
health
burden,
contributing
substantially
to
morbidity
and
mortality,
especially
among
hospitalized
patients.
EGFR
has
emerged
as
prime
therapeutic
target
due
its
pivotal
role
in
driving
uncontrolled
cell
growth
survival
across
numerous
cancer
types.
In
addition,
DNA
gyrase
represents
promising
for
development
novel
antimicrobial
agents.
Therefore,
we
aimed
design
synthesize
new
multi-target
quinoline
hybrids
(7-17e)
capable
acting
anti-proliferative
agents
inhibiting
microbial
gyrase,
respectively.
The
inhibitory
potential
synthesized
compounds
was
determined
using
Language: Английский