New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases DOI Creative Commons
Yu‐Qing Ni, You‐Shuo Liu

Aging and Disease, Journal Year: 2021, Volume and Issue: 12(8), P. 1948 - 1948

Published: Jan. 1, 2021

High incidences of morbidity and mortality associated with age-related diseases among the elderly population are a socio-economic challenge. Aging is an irreversible inevitable process that risk factor for pathological progression diverse diseases. Spermidine, natural polyamine, plays critical role in molecular cellular interactions involved various physiological functional processes. Spermidine has been shown to modulate aging, suppress occurrence severity diseases, prolong lifespan. However, precise mechanisms through which spermidine exerts its anti-aging effects have not established. In this review, we elucidate on roles underlying beneficial aging from perspective. Moreover, provide new insights into promising potential diagnostic therapeutic applications

Language: Английский

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study DOI Creative Commons
Pengsheng Li, Haiyan Wang, Lan Guo

et al.

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 15, 2022

Abstract Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of on preeclampsia-eclampsia unknown. Methods A two-sample Mendelian randomization study was performed using summary statistics from largest available genome-wide association meta-analysis ( n =13,266) conducted by MiBioGen consortium. The were obtained FinnGen consortium R7 release data (5731 cases and 160,670 controls). Inverse variance weighted, maximum likelihood, MR-Egger, weighted median, model, MR-PRESSO, cML-MA used to examine between preeclampsia-eclampsia. Reverse analysis bacteria found be causally in forward analysis. Cochran’s Q quantify heterogeneity instrumental variables. Results estimates suggested Bifidobacterium had a protective (odds ratio = 0.76, 95% confidence interval: 0.64–0.89, P 8.03 × 10 −4 ). In addition, Collinsella 0.77, 0.60–0.98, 0.03), Enterorhabdus 0.62–0.93, 8.76 −3 ), Eubacterium (ventriosum group) 0.63–0.91, 2.43 Lachnospiraceae (NK4A136 0.65–0.92, 3.77 Tyzzerella 3 0.85, 0.74–0.97, 0.01) presented suggestive According results reverse MR analysis, no significant microbiota. No variables or horizontal pleiotropy found. Conclusions This Further randomized controlled trials are needed clarify probiotics their specific mechanisms.

Language: Английский

Citations

412
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review DOI Creative Commons
Amrita Vijay, Ana M. Valdes

European Journal of Clinical Nutrition, Journal Year: 2021, Volume and Issue: 76(4), P. 489 - 501

Published: Sept. 28, 2021

Language: Английский

Citations

328
Gut barrier disruption and chronic disease DOI
Jan Martel, Shih-Hsin Chang,

Yun‐Fei Ko

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2022, Volume and Issue: 33(4), P. 247 - 265

Published: Feb. 9, 2022

Language: Английский

Citations

299
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon DOI Creative Commons
Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 8, 2021

Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by intestinal microbiota regulate multiple processes. Increased colonic luminal polyamines promote longevity in mice. However, no direct evidence has shown that microbial incorporated into host cells to cellular responses. Here, we show reinforce epithelial proliferation macrophage differentiation. Colonisation wild-type, but not polyamine biosynthesis-deficient, Escherichia coli germ-free mice raises intracellular levels colonocytes, accelerating renewal. Commensal bacterium-derived increases abundance of anti-inflammatory macrophages colon. The bacterial ameliorate symptoms dextran sulfate sodium-induced colitis These effects mainly result from enhanced hypusination eukaryotic initiation translation factor. We conclude functions a substrate symbiotic metabolism is further absorbed metabolised host, thus helping maintain mucosal homoeostasis intestine.

Language: Английский

Citations

162
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment DOI Creative Commons
Safae Terrisse, Lisa Derosa, Valerio Iebba

et al.

Cell Death and Differentiation, Journal Year: 2021, Volume and Issue: 28(9), P. 2778 - 2796

Published: May 7, 2021

Abstract The prognosis of early breast cancer (BC) relies on cell autonomous and immune parameters. impact the intestinal microbiome clinical outcome has not yet been evaluated. Shotgun metagenomics was used to determine composition fecal microbiota in 121 specimens from 76 BC patients, 45 whom were paired before after chemotherapy. These patients enrolled CANTO prospective study designed record side effects associated with management BC. We analyzed associations between baseline or post-chemotherapy plasma metabolomics prognosis, as well therapy-induced effects. examined relevance these findings immunocompetent mice colonized patient that subsequently challenged histo-compatible mouse conclude specific gut commensals are overabundant compared healthy individuals negatively modulated by chemotherapy, may influence weight gain neurological therapies. obtained adjuvant neoadjuvant settings warrant validation.

Language: Английский

Citations

123
Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites DOI Creative Commons
Claudia Grajeda‐Iglesias, Sylvère Durand,

Romain Daillère

et al.

Aging, Journal Year: 2021, Volume and Issue: 13(5), P. 6375 - 6405

Published: March 2, 2021

teaching and research institutions in France or abroad, from public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.

Citations

119
Clostridium butyricum and Its Derived Extracellular Vesicles Modulate Gut Homeostasis and Ameliorate Acute Experimental Colitis DOI Creative Commons

Lingyan Ma,

Qichen Shen, Wentao Lyu

et al.

Microbiology Spectrum, Journal Year: 2022, Volume and Issue: 10(4)

Published: June 28, 2022

This study indicated that C. butyricum provided a prevention effect against colitis mice, which involved protection of the intestinal barrier and positively regulating gut microbiota. Furthermore, we confirmed microbiota metabolites were induced by also contributed to attenuation DSS-induced colitis. Importantly, -derived EVs showed an effective impact in alleviating

Language: Английский

Citations

118
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis DOI Creative Commons
Xinyue Wang, Sisi Lin, Lu Wang

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(11)

Published: March 15, 2023

Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota-derived OMVs the intestine remain poorly understood. Here, we report that released from Akkermansia muciniphila are able to (i) restore disturbed balance microbiota by selectively promoting proliferation beneficial bacteria through fusion, (ii) elicit mucosal immunoglobulin A response translocating into Peyer's patches subsequently activating B cells dendritic cells, (iii) maintain integrity intestinal barrier entering epithelial stimulate expressions tight junctions mucus. We demonstrate transplantation microbiota-associated can alleviate colitis enhance anti-programmed cell death protein 1 therapy against colorectal cancer regulating homeostasis. This work discloses importance ecology, providing an alternative target for disease intervention treatment.

Language: Английский

Citations

108
Mechanisms of spermidine-induced autophagy and geroprotection DOI Open Access
Sebastian J. Hofer, Anna Katharina Simon, Martina Bergmann

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 2(12), P. 1112 - 1129

Published: Dec. 22, 2022

Language: Английский

Citations

98
Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression DOI Creative Commons

Liyan Lin,

Keyi Zhang, Qiao Xiong

et al.

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103001 - 103001

Published: March 15, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive polyarthritis that leads to cartilage and bone damage. Pre-clinical RA prolonged state before clinical develop, in which autoantibodies (antibodies against citrullinated proteins, rheumatoid factors) can be present due the breakdown of immunologic self-tolerance. As early treatment initiation onset may achieve sustained remission, optimize outcomes, even prevent progression, pre-clinical stage showing prospect window opportunity for treatment. Growing evidence has shown role gut microbiota inducing systemic inflammation via multiple mechanisms, involve molecular mimicry, impaired intestinal barrier function, microbiota-derived metabolites mediated immune regulation, modulation microbiota's effect on cells, epithelial cells autophagy, interaction between microbiome human leukocyte antigen alleles as well microRNAs. Since alterations have been reported, potential therapies modifying RA, including natural products, antibiotic therapy, fecal transplantation, probiotics, microRNAs vitamin D supplementation, autophagy inducer-based treatment, prebiotics, diet, holds great promise successful prevention altering ongoing inflammation. In this review, we summarized current studies include pathogenesis progression promising therapeutic strategies provide novel ideas management possibly preventing progression.

Language: Английский

Citations

59