Fecal microbiota transplantation treatment for type 1 diabetes mellitus with malnutrition: a case report DOI Creative Commons
Yanchun Xie,

Xubin Jing,

Xiang Chen

et al.

Therapeutic Advances in Chronic Disease, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 1, 2022

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease. Not only genetics, but the intestinal environment affected by gut microbiota also key to pathogenesis. Besides occurrence of diabetes, dysbiosis may contribute development diabetes-related complications. Fecal transplantation (FMT) an emerging technique that had shown its potential as treatment for metabolic Here, we report first case T1DM with malnutrition and gastrointestinal symptoms treated FMT. A 24-year-old patient suffered from poor blood glucose control, recurrent nausea vomiting, severe malnutrition, intractable constipation after insulin treatment. The clinical response patients FMT was well, especially vomiting were significantly relieved. In addition, constipation, nutritional status, control (fasting glucose, HbA1c) gradually improved. degree similarity found in composition between healthy donor while it totally different before Furthermore, pathway function analysis MetaCYC database implies mechanism be driven specific bacteria involved several pathways need further exploration. To sum up, believe reconstruction flora new choice malnutrition.

Language: Английский

Lactobacillus murinus alleviate intestinal ischemia/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via Toll-like receptor 2 signaling DOI Creative Commons

Jingjuan Hu,

Fan Deng,

Bing-Cheng Zhao

et al.

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: March 3, 2022

Intestinal ischemia/reperfusion (I/R) injury has high morbidity and mortality rates. Gut microbiota is a potential key factor affecting intestinal I/R injury. Populations exhibit different sensitivities to injury; however, whether this interpopulation difference related variation in gut unclear. Here, elucidate the interaction between microbiome injury, we performed 16S DNA sequencing on preoperative feces of C57BL/6 mice fecal transplantation (FMT) experiments germ-free mice. The transwell co-culture system small organoids extracted from control macrophages or Toll-like receptor 2 (TLR2)-deficient interleukin-10 (IL-10)-deficient were established separately explore mechanism reducing injury.Intestinal I/R-sensitive (Sen) I/R-resistant (Res) first defined according survival outcomes suffering I/R. Fecal composition diversity prior ischemia differed Sen Res relative abundance Lactobacillus murinus (L. murinus) at species level was drastically higher than that Clinically, L. patients undergoing cardiopulmonary bypass surgery closely degree after surgery. Treatment with significantly prevented I/R-induced improved mouse survival, which depended involvement. Further, vitro indicated promoting release IL-10 through TLR2 may be for reduce injury.The involved postoperative outcome alleviates macrophages, This study revealed novel new therapeutic strategy clinical practice. Video Abstract.

Language: Английский

Citations

147
Microbiota revolution: How gut microbes regulate our lives DOI Creative Commons
Marica Colella, Ioannis Alexandros Charitos, Andrea Ballini

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(28), P. 4368 - 4383

Published: July 26, 2023

The human intestine is a natural environment ecosystem of complex diversified and dynamic microorganisms, determined through process competition selection during life. Those intestinal microorganisms called microbiota are involved in variety mechanisms the organism, they interact with host therefore contact organs various systems. However, play crucial role maintaining homeostasis, also influencing its behaviour. Thus, perform series biological functions important for well-being. provides nutrients, simultaneously drawing many benefits such as their contribution to metabolic, trophic, immunological, other functions. For these reasons it has been reported that quantitative qualitative composition can protective or harmful on health. Therefore, dysbiosis lead an association unfavourable factors which dysregulation physiological processes homeostasis. pre-viously noted gut participate pathogenesis autoimmune diseases, chronic inflammation, diabetes mellitus, obesity atherosclerosis, neurological disorders (e.g., autism, etc.) colorectal cancer, more.

Language: Английский

Citations

68
Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression DOI Creative Commons

Liyan Lin,

Keyi Zhang, Qiao Xiong

et al.

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103001 - 103001

Published: March 15, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive polyarthritis that leads to cartilage and bone damage. Pre-clinical RA prolonged state before clinical develop, in which autoantibodies (antibodies against citrullinated proteins, rheumatoid factors) can be present due the breakdown of immunologic self-tolerance. As early treatment initiation onset may achieve sustained remission, optimize outcomes, even prevent progression, pre-clinical stage showing prospect window opportunity for treatment. Growing evidence has shown role gut microbiota inducing systemic inflammation via multiple mechanisms, involve molecular mimicry, impaired intestinal barrier function, microbiota-derived metabolites mediated immune regulation, modulation microbiota's effect on cells, epithelial cells autophagy, interaction between microbiome human leukocyte antigen alleles as well microRNAs. Since alterations have been reported, potential therapies modifying RA, including natural products, antibiotic therapy, fecal transplantation, probiotics, microRNAs vitamin D supplementation, autophagy inducer-based treatment, prebiotics, diet, holds great promise successful prevention altering ongoing inflammation. In this review, we summarized current studies include pathogenesis progression promising therapeutic strategies provide novel ideas management possibly preventing progression.

Language: Английский

Citations

56
Short chain fatty acids, a possible treatment option for autoimmune diseases DOI Open Access

Faezeh Golpour,

Mehrsa Abbasi-Alaei,

Fatemeh Babaei

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114763 - 114763

Published: April 25, 2023

Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty acids (SCFAs), as one of most abundant metabolites resident gut play an important role in this crosstalk. SCFAs (acetate, propionate, and butyrate) regulate nearly every type cell gut's repertoire regarding their development function. work several pathways to impose protection towards colonic health against local or systemic inflammation. Additionally, a regulation non-immune that slow autoimmunity either systematically situ. The present study aims summarize current knowledge on immunomodulatory roles association between autoimmune disorders such celiac disease (CD), inflammatory bowel (IBD), rheumatoid arthritis (RA), multiple sclerosis (MS), lupus erythematosus (SLE), 1 diabetes (T1D) other immune-mediated diseases, uncovering brand-new therapeutic possibility prevent treat autoimmunity.

Language: Английский

Citations

56
Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer DOI
Wenshuai Li, Qi Zhou,

Bin Lv

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(21), P. 12072 - 12082

Published: May 16, 2024

polysaccharide (GLP) is a prebiotic with immunomodulatory effects. However, the therapeutic potential of GLP in tumor immunotherapy has not been fully explored, especially T cell-mediated antitumor immunity. In this study, we found that significantly inhibited growth and activated immunity colorectal cancer (CRC). spleens tissues, proportion cytotoxic CD8

Language: Английский

Citations

19
Pathogenesis of Type 1 Diabetes: Established Facts and New Insights DOI Open Access

Ana Zajec,

Katarina Trebušak Podkrajšek, Tine Tesovnik

et al.

Genes, Journal Year: 2022, Volume and Issue: 13(4), P. 706 - 706

Published: April 16, 2022

Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated destruction of insulin-producing β-cells in pancreatic islets. It generally occurs genetically susceptible individuals, and genetics plays a major role development islet autoimmunity. Furthermore, these processes are heterogeneous among individuals; hence, different endotypes have been proposed. In this review, we highlight interplay between genetic predisposition other non-genetic factors, such as viral infections, diet, gut biome, which all potentially contribute to aetiology T1D. We also discuss possible active for initiating pathological processes. Another component T1D epigenetic influences, represent link susceptibility environmental factors may account some heterogeneity. Accordingly, shift towards personalized therapies improve treatment results and, therefore, result better outcomes individuals long-run. There clear need understanding preclinical phases finding new predictive biomarkers earlier diagnosis therapy, with final goal reverting or even preventing disease.

Language: Английский

Citations

53
Gut microbiota and type 1 diabetes: a two-sample bidirectional Mendelian randomization study DOI Creative Commons

Manjun Luo,

Mengting Sun, Tingting Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 29, 2023

Objective The real causal relationship between human gut microbiota and T1D remains unclear difficult to establish. Herein, we adopted a two-sample bidirectional mendelian randomization (MR) study evaluate the causality T1D. Methods We leveraged publicly available genome-wide association (GWAS) summary data perform MR analysis. microbiota-related GWAS from 18,340 individuals international consortium MiBioGen were used. statistic for (n = 264,137) obtained latest release FinnGen as outcome of interest. selection instrumental variables conformed strictly series preset inclusion exclusion criteria. MR-Egger, weighted median, inverse variance (IVW), mode methods used assess association. Cochran’s Q test, MR-Egger intercept leave-one-out analysis conducted identify heterogeneity pleiotropy. Results At phylum level, only Bacteroidetes was indicated have on (OR 1.24, 95% CI 1.01-1.53, P 0.044) in IVW When it comes their subcategories, Bacteroidia class 1.28, 1.06-1.53, 0.009, FDR 0.085), Bacteroidales order Eubacterium eligens group genus 0.64, 0.50-0.81, 2.84×10 -4 , 0.031) observed with No pleiotropy detected. Conclusions present reports that phylum, class, causally increase risk, whereas genus, which belongs Firmicutes decreases risk. Nevertheless, future studies are warranted dissect underlying mechanisms specific bacterial taxa’s role pathophysiology

Language: Английский

Citations

34
Infant gut microbiome composition correlated with type 1 diabetes acquisition in the general population: the ABIS study DOI

Malin Bélteky,

Patricia L. Milletich, Angelica P. Ahrens

et al.

Diabetologia, Journal Year: 2023, Volume and Issue: 66(6), P. 1116 - 1128

Published: March 25, 2023

Language: Английский

Citations

27
Efficacy of Fasting in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review DOI Open Access

Daniel Herz,

Sandra Haupt, Rebecca T. Zimmer

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3525 - 3525

Published: Aug. 10, 2023

Over the last decade, studies suggested that dietary behavior modification, including fasting, can improve metabolic and cardiovascular markers as well body composition. Given increasing prevalence of people with type 1 (T1DM) 2 diabetes mellitus (T2DM) obesity (also in combination diabetes), nutritional therapies are gaining importance, besides pharmaceutical interventions. Fasting has demonstrated beneficial effects for both healthy individuals those diseases, leading to increased research interest its impact on glycemia associated short- long-term complications. Therefore, this review aimed investigate whether fasting be used safely effectively addition medications support therapy T1DM T2DM. A literature search interaction was conducted via PubMed September 2022. potential minimize risk hypoglycemia T1DM, lower glycaemic variability, fat metabolism It also increases insulin sensitivity, reduces endogenous glucose production diabetes, lowers weight, improves To conclude, is efficient management T2DM performed, when necessary, health care professionals.

Language: Английский

Citations

24
The nutritional function of active polysaccharides from marine animals: A review DOI
Guan Xin, Fuyi Wang,

Boqian Zhou

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103693 - 103693

Published: Feb. 2, 2024

Language: Английский

Citations

10