Brain and Behavior,
Journal Year:
2025,
Volume and Issue:
15(3)
Published: Feb. 28, 2025
ABSTRACT
Purpose
:
The
intestinal
immune
compartment
is
increasingly
recognized
as
an
important
player
in
central
nervous
system
(CNS)
autoimmunity.
We
have
recently
reported
that
oral
administration
of
the
free
fatty
acid
receptor
2
(FFAR2)
agonist
Cpd1
inductive
phase
experimental
autoimmune
encephalomyelitis
(EAE)
rats
ameliorates
disease
by
stimulating
regulatory
response
intestine.
Method
Here,
effects
on
gut
microbiota
and
short‐chain
(SCFA)
composition
were
investigated
same
system.
Finding
Increased
levels
phylum
Proteobacteria
,
class
Gammaproteobacteria
orders
Burkholderiales
Erysipelotrichales
families
Sutterellaceae
Erysipelotrichaceae
genera
Parasutterella
Faecalibaculum
observed
agonist‐treated
rats.
Allobaculum
Ileibacterium
only
detected
group.
treatment
led
to
changes
functional
profile
both
KEGG
orthologous
pathways
clusters
genes.
In
addition,
altered
SCFA
content
was
Conclusion
are
relevant
benefit
FFAR2
agonism
EAE
model
during
disease.
Current Clinical Microbiology Reports,
Journal Year:
2024,
Volume and Issue:
11(1), P. 18 - 33
Published: Jan. 16, 2024
Abstract
Purpose
of
Review
This
review
provides
an
overview
the
role
dysbiosis
(imbalanced
gut
microbiota)
in
maintenance
host
homeostasis
and
immune
function
summarizes
recent
evidence
connecting
microbiota
to
development
autoimmune
diseases
(ADs)
(such
as
rheumatoid
arthritis,
type
1
diabetes,
systemic
lupus
erythematosus,
multiple
sclerosis,
spondyloarthritis,
irritable
bowel
syndrome).
The
potential
mechanisms
that
underlie
host-microbiota
interaction
are
also
discussed
evaluate
manipulation
a
therapeutic
approach
managing
ADs.
Additionally,
this
addresses
current
challenges
microbiota-host
research
future
recommendations.
Recent
Findings
findings
suggested
pathogenesis
ADs
appears
be
multifaceted
involving
both
genetic
environmental
factors.
Dysbiosis
or
imbalanced
has
been
increasingly
identified
one
main
factors
can
modulate
responses
contribute
Summary
New
highlighted
significance
microbial
etiology
numerous
diseases.
Understanding
relationship
between
host,
however,
goes
beyond
taxonomic
concerns,
demanding
multidisciplinary
efforts
design
new
approaches
take
individual
variances
into
account.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3198 - 3198
Published: March 11, 2024
Multiple
sclerosis
(MS)
is
a
chronic
inflammatory
and
neurodegenerative
central
nervous
system
(CNS)
disorder,
characterized
by
focal
inflammation,
demyelination,
irreversible
axonal
loss
neurodegeneration.
The
proposed
mechanism
involves
auto-reactive
T
lymphocytes
crossing
the
blood–brain
barrier
(BBB),
contributing
to
inflammation
demyelination.
Pro-inflammatory
Th1
Th17
are
pivotal
in
MS
pathogenesis,
highlighting
an
imbalanced
interaction
with
regulatory
cells.
Dysbiosis
gut
microbiota,
microbial
imbalance
implicated
systemic
yet
its
exact
role
remains
elusive.
Short-chain
fatty
acids
(SCFAs),
including
valerate,
butyrate,
propionate,
acetate,
produced
through
dietary
fiber
fermentation
modulate
immune
responses.
Particularly,
butyrate
propionate
exhibit
pronounced
anti-inflammatory
effects
both
CNS.
These
SCFAs
influence
lymphocyte
expression
BBB
permeability.
This
review
discusses
potential
therapeutic
implications
of
SCFA
MS,
their
ability
gut–brain
axis
restore
balance.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6539 - 6539
Published: June 13, 2024
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
condition
with
high
prevalence
worldwide.
AD
pathogenesis
complex
and
consists
of
immune
system
dysregulation
impaired
barrier,
influenced
by
genetic
environmental
factors.
The
purpose
the
review
to
show
interplay
between
atopic
microbiota.
Human
microbiota
plays
an
important
role
in
course
disease.
Dysbiosis
factor
contributing
development
diseases,
including
dermatitis.
gut
can
influence
composition
microbiota,
strengthening
barrier
regulating
response
via
involvement
bacterial
metabolites,
particularly
short-chain
fatty
acids,
signaling
pathways
gut–skin
axis.
be
modulated
antibiotic
intake,
dietary
adjustments,
hygiene,
living
conditions.
One
promising
strategies
for
modulating
probiotics.
This
offers
summary
how
influences
treatment
AD,
highlighting
aspects
that
warrant
additional
investigation.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: April 19, 2024
All
microorganisms
like
bacteria,
viruses
and
fungi
that
reside
within
a
host
environment
are
considered
microbiome.
The
number
of
bacteria
almost
equal
human
cells,
however,
the
genome
these
may
be
100
times
larger
than
genome.
Every
aspect
physiology
health
can
influenced
by
microbiome
living
in
various
parts
our
body.
Any
imbalance
composition
or
function
is
seen
as
dysbiosis.
Different
types
dysbiosis
corresponding
symptoms
depend
on
site
microbial
imbalance.
contribution
intestinal
extra-intestinal
microbiota
to
influence
systemic
activities
through
interplay
between
different
axes.
Whole
body
complex
process
involving
gut
non-gut
related
It
still
at
stage
infancy
has
not
yet
been
fully
understood.
Dysbiosis
genetic
factors,
lifestyle
habits,
diet
including
ultra-processed
foods
food
additives,
well
medications.
associated
with
many
diseases
cannot
diagnosed
standard
blood
tests
investigations.
Microbiota
derived
metabolites
analyzed
useful
management
addressed
altering
proper
modulation.
effect
interventions
humans
depends
beneficial
alteration
mostly
based
animal
studies
evolving
evidence
from
studies.
There
tremendous
potential
for
diagnosis,
treatment,
prognosis
diseases,
as,
monitoring
disease
humans.
system-based
approach
diagnosis
better
pure
taxonomic
approach.
could
new
therapeutic
target
conditions.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(4), P. e26377 - e26377
Published: Feb. 1, 2024
Short-chain
fatty
acids
(SCFAs)
are
thought
to
play
a
key
role
in
the
microbe-gut-brain
axis
and
involve
pathogenesis
of
variety
neurological
diseases.
This
study
aimed
identify
research
hotspots
evolution
trends
SCFAs
central
nervous
diseases
(CNS)
examine
current
trends.
