Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 21, 2024
Background
This
study
aimed
to
clarify
the
relationship
between
gut
microbiota
and
osteoporosis
combining
Mendelian
randomization
(MR)
analysis
with
animal
experiments.
Methods
We
conducted
an
on
differential
bacteria
using
open-access
genome-wide
association
(GWAS)
data
microbe
obtained
from
public
databases.
The
was
performed
two-sample
MR
analysis,
causal
examined
through
inverse
variance
weighting
(IVW),
Egger,
weighted
median,
mode
methods.
Bilateral
oophorectomy
employed
replicate
mouse
model,
which
assessed
by
micro
computed
tomography
(CT),
pathological
tests,
bone
transformation
indexes.
Additionally,
16S
rDNA
sequencing
fecal
samples,
while
SIgA
indexes
of
IL-6,
IL-1β,
TNF-α
inflammatory
factors
were
in
colon
samples.
Through
immunofluorescence
histopathology,
expression
levels
tight
junction
proteins,
such
as
claudin-1,
ZO-1,
occludin,
assessed,
conduct
correlation
related
environmental
performed.
Results
A
positive
observed
g_Ruminococcus1
risk
osteoporosis,
O_Burkholderiales
showed
a
negative
osteoporosis.
Furthermore,
there
no
evidence
heterogeneity
or
pleiotropy.
successful
replication
model
it
found
that
abundance
significantly
reduced,
g_Ruminococcus
increased
ovariectomized
(OVX)-mice.
intestinal
level
OVX
mice
decreased,
increased,
barrier
damage
occurred,
content
LPS
serum
increased.
is
strongly
positively
correlated
formation
factors,
indicators,
density,
volume
fraction,
trabecular
quantity,
whereas
negatively
resorption
shows
strong
factors.
Conclusion
may
regulate
development
microbiota-gut-bone
axis.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(34), P. e39471 - e39471
Published: Aug. 23, 2024
Osteoporosis
is
a
systemic
skeletal
disease
characterized
by
low
bone
density
and
microarchitectural
deterioration,
resulting
in
increased
fracture
risk.
With
an
aging
population,
osteoporosis
imposes
heavy
burden
worldwide.
Current
pharmacotherapies
such
as
bisphosphonates
can
reduce
risk
but
have
limitations.
Emerging
research
suggests
that
gut
microbiota
regulates
metabolism
through
multiple
mechanisms.
Short-chain
fatty
acids
(SCFAs)
produced
from
microbial
fermentation
of
dietary
fiber
beneficially
impact
health.
Preclinical
studies
indicate
SCFAs
butyrate
propionate
prevent
loss
models
inhibiting
osteoclastogenesis
immune
modulation.
Early
clinical
data
also
suggest
SCFA
supplementation
may
improve
turnover
markers
postmenopausal
women.
likely
act
via
inhibition
osteoclast
differentiation,
stimulation
osteoblast
activity,
regulation
T
cells,
other
pathways.
However,
optimal
dosing,
delivery
methods,
long-term
safety
require
further
investigation.
Modulating
the
gut-bone
axis
supplementation,
prebiotics/probiotics,
diet,
lifestyle
interventions
represents
innovative
therapeutic
approach
for
osteoporosis.
Harnessing
interplay
between
microbiome,
metabolism,
immunity,
provide
new
directions
managing
future.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 10871 - 10871
Published: Oct. 10, 2024
Probiotics,
known
for
regulating
gut
microbiota,
may
aid
those
with
overweight
or
obesity,
but
their
mechanisms
require
more
research.
This
study
involved
75
obese
young
adults,
randomly
assigned
to
either
a
Microbiological Research,
Journal Year:
2025,
Volume and Issue:
293, P. 128047 - 128047
Published: Jan. 9, 2025
Male
osteoporosis
is
primarily
caused
by
a
decrease
in
testicular
testosterone
production.
remains
disease
with
insufficient
diagnosis
and
treatment,
its
consequences
are
severe,
especially
older
patients.
The
gut
microbiota
plays
crucial
role
occurrence
development.
Our
study
found
that
the
relative
abundance
of
Lactobacillus
salivarius
fecal
male
patients
was
significantly
lower
than
healthy
volunteers.
Animal
experiments
have
shown
orchiectomy
(ORX)
can
induce
disrupt
intestinal
mucosal
barrier,
microbiota.
In
addition,
we
discovered
potential
etiological
connection
between
decreased
bacterium
L.
ORX-induced
osteoporosis.
Cohousing
or
direct
colonization
from
rats
oral
administration
bacteria
alleviated
repaired
barrier.
Finally,
demonstrated
extracellular
vesicles
(EVs)
could
be
transported
to
bones
mitigate
rats.
results
indicate
participates
protecting
secreting
delivering
bacterial
EVs,
reduction
EVs
closely
related
development
androgen
deficiency-related
