bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 11, 2023
Abstract
Gene-environment
interactions
shape
animal
behavior
and
the
susceptibility
to
neurobehavioral
symptoms
such
as
depression.
However,
little
is
known
about
signaling
pathway
that
integrates
genetic
environmental
inputs
with
outcomes,
preventing
development
of
targeted
therapies.
Here
we
report
Gpr35
engages
a
gut
microbe-to-brain
metabolic
modulate
neuronal
plasticity
depressive
in
mice.
Chronic
stress
decreases
epithelial
,
deletion
which
induces
despair
social
impairment
microbiome-dependent
manner.
We
identify
dominant
role
for
imbalance
microbe-derived
indole-3-carboxaldehyde
(IAld)
indole-3-lactate
(ILA)
behavioral
deficiency.
Mechanistically,
these
bacterial
metabolites
counteractively
dendritic
spine
density
synaptic
transmission
nucleus
accumbens.
Supplementation
IAld,
similarly
decreased
patients,
produce
anti-depressant
effects
mice
or
Together,
findings
genetics-shaped
gut-brain
connection
underlying
depression
suggest
microbial
metabolite-based
therapeutic
strategy
predisposition.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(17), P. 3859 - 3859
Published: Sept. 4, 2023
Depressive
disorders
pose
significant
challenges
to
global
public
health,
necessitating
effective
prevention
and
management
strategies.
Notably,
the
occurrence
of
suicide
frequently
coincides
with
depressive
episodes.
Suicide
is
as
a
paramount
health
concern
that
demands
efficacious
preventive
Current
psychiatric
approaches
heavily
rely
on
pharmacological
interventions
but
have
had
limited
success
in
addressing
burden
mental
issues.
Suboptimal
nutrition,
its
impact
neuroendocrine
system,
has
been
implicated
underlying
pathology
disorders.
Folate,
group
water-soluble
compounds,
plays
crucial
role
various
central
nervous
system
functions.
Depressed
individuals
often
exhibit
low
levels
serum
red
blood
cell
folate.
Multiple
studies
systematic
reviews
investigated
efficacy
folic
acid
derivative,
L-methylfolate,
which
can
cross
blood–brain
barrier,
stand-alone
or
adjunct
therapies
for
depression.
Although
findings
mixed,
available
evidence
generally
supports
use
these
compounds
depressed
individuals.
Recent
established
links
between
one-carbon
cycle,
folate–homocysteine
balance,
immune
function,
glutamate
excitation
via
NMDA
(N-methyl-D-aspartate)
receptors,
gut
microbiome
eubiosis
mood
regulation.
These
provide
insights
into
complex
neurobiological
mechanisms
effects
folate
related
Through
comprehensive
review
existing
literature,
this
study
aims
advance
our
understanding
therapeutic
potential
depression
treatment.
It
also
seeks
explore
their
suicidal
tendencies
shed
light
involved,
leveraging
latest
discoveries
research.
Genes,
Journal Year:
2023,
Volume and Issue:
14(7), P. 1506 - 1506
Published: July 24, 2023
Nutrition
and
metabolism
modify
epigenetic
signatures
like
histone
acetylation
DNA
methylation.
Histone
methylation
in
the
central
nervous
system
(CNS)
can
be
altered
by
bioactive
nutrients
gut
microbiome
via
gut-brain
axis,
which
turn
modulate
neuronal
activity
behavior.
Notably,
microbiome,
with
more
than
1000
bacterial
species,
collectively
contains
almost
three
million
functional
genes
whose
products
interact
millions
of
human
marks
30,000
a
dynamic
manner.
However,
genetic
makeup
shapes
composition,
food/nutrient
metabolism,
landscape,
as
well.
Here,
we
first
discuss
effect
changes
microbial
structure
composition
shaping
specific
alterations
brain
their
role
onset
progression
major
mental
disorders.
Afterward,
potential
interactions
among
maternal
diet/environmental
factors,
nutrition,
gastrointestinal
roles
accelerating
or
delaying
severe
illnesses
will
discussed.
We
also
provide
an
overview
association
between
oxidative
stress,
inflammation
through
mechanisms.
Finally,
present
some
underlying
mechanisms
involved
mediating
influence
probiotics
on
health
modifications.
Laws,
Journal Year:
2024,
Volume and Issue:
13(4), P. 46 - 46
Published: July 11, 2024
International
studies
have
linked
the
consumption
of
ultra-processed
foods
with
a
variety
non-communicable
diseases.
Included
in
this
growing
body
research
is
evidence
linking
to
mental
disorders,
aggression,
and
antisocial
behavior.
Although
idea
that
dietary
patterns
various
nutrients
or
additives
can
influence
brain
behavior
has
long
history
criminology,
absence
plausible
mechanisms
convincing
intervention
trials,
topic
was
mostly
excluded
from
mainstream
discourse.
The
emergence
across
nutritional
neuroscience
psychology/psychiatry,
combined
mechanistic
bench
science,
human
provided
support
epidemiological
findings,
legitimacy
concept
criminology.
Among
emergent
research,
microbiome
sciences
illuminated
pathways
socioeconomic
environmental
factors,
including
foods,
aggression
Here
review,
we
examine
burgeoning
related
food
addiction,
explore
its
relevance
criminal
justice
spectrum—from
prevention
intervention—and
courtroom
considerations
diminished
capacity.
We
use
auto-brewery
syndrome
as
an
example
intersecting
diet
gut
science
been
used
refute
mens
rea
charges.
legalome—microbiome
omics
applied
forensic
legal
psychology—appears
set
emerge
important
consideration
matters
law,
justice.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 19, 2024
Probiotics
are
live
microorganisms
that
offer
potential
benefits
to
their
hosts
and
can
occasionally
influence
behavioral
responses.
However,
the
detailed
mechanisms
by
which
probiotics
affect
behavior
of
underlying
biogenic
effects
remain
unclear.
Lactic
acid
bacteria,
specifically
Lactobacillus
spp.
known
probiotics.
Drosophila
melanogaster,
commonly
as
fruit
fly,
is
a
well-established
model
organism
for
investigating
interaction
between
host
gut
microbiota
in
translational
research.
Herein,
we
showed
5-day
administration
acidophilus
(termed
GMNL-185)
or
Lacticaseibacillus
rhamnosus
GMNL-680)
enhances
olfactory-associative
memory
Drosophila.
Moreover,
combined
diet
GMNL-185
GMNL-680
demonstrated
synergistic
on
functions.
Live
brain
imaging
revealed
significant
increase
calcium
responses
training
odor
mushroom
body
β
γ
lobes
flies
underwent
mixed
feeding
with
GMNL-680.
Quantitative
reverse
transcription
polymerase
chain
reaction
(qRT-PCR)
whole-mount
immunohistochemistry
upregulation
lactate
dehydrogenase
(LDH)
expression
fly
following
feeding.
Notably,
genetic
knockdown
Ldh
neurons,
body,
ameliorated
beneficial
improvement.
Altogether,
our
results
demonstrate
supplementation
L.
functions
increasing
LDH
levels.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Triterpenoids
derived
from
plants
are
a
promising
class
of
natural
antidepressants.
This
research
focused
on
the
therapeutic
potential
quinoa
saponin
(QS)
in
alleviating
lipopolysaccharide
(LPS)-induced
anxiety
and
depressive-like
behaviors
mice.
The
most
abundant
fraction,
QS–3,
was
isolated
QS
extracts,
its
major
components
chemical
structure
were
elucidated.
Six
pentacyclic
triterpene
saponins
three
tetracyclic
identified
with
phytolaccagenin
oleanolic
acid
being
dominant
sapogenins.
In
vivo
studies
demonstrated
that
significantly
mitigated
LPS-induced
mice,
enhanced
levels
neurotrophic
proteins,
key
synaptic
neurotransmitters,
restored
function
neuronal
damage.
Furthermore,
inhibited
neuroinflammation
by
curtailing
activity
TLR4/MyD88/NF-κB
pathway
modulating
microglial
phenotypes.
Notably,
also
ameliorated
colonic
inflammation
promoting
gut
microbiota
homeostasis
increasing
short-chain
fatty
acids
(SCFAs)
production,
which
contributed
to
improvement
depressive
Our
findings
suggest
holds
as
dietary
supplement
for
treatment
prevention
depression,
possibly
through
modulation
gut-brain
axis
dynamics
suppression
activation
pathway.
