Weissella viridescens Attenuates Hepatic Injury, Oxidative Stress, and Inflammation in a Rat Model of High-Fat Diet-Induced MASLD DOI Open Access
Shuwei Zhang, R. Zhao,

Ruoshi Wang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1585 - 1585

Published: May 5, 2025

Background/Objectives: Metabolic-dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic disorder globally. Probiotic supplementation has shown promise in its prevention and treatment. Although Weissella viridescens, a lactic acid bacterium with immunomodulatory effects, antibacterial anti-inflammatory activities, there lack of direct evidence for role MASLD. This study aimed to investigate protective effects W. viridescens strain Wv2365, isolated from healthy human feces, high-fat diet (HFD)-induced rat model Methods: Rats were randomly assigned normal chow (NC), (HFD), HFD supplemented Wv2365 (Wv2365) groups. All groups fed their respective diets 8 weeks. During this period, NC received daily oral gavage PBS, while group Wv2365. Results: significantly reduced HFD-induced body weight gain, improved NAFLD activity scores, alleviated hepatic injury, restored lipid metabolism. A transcriptomic analysis revealed downregulation inflammation-related pathways, along decreased serum levels TNF-α, IL-1β, IL-6, MCP-1, LPS. also activated Nrf2/HO-1 antioxidant pathway, enhancing enzyme activities reducing malondialdehyde (MDA) levels. gut microbiota showed enrichment beneficial genera, including Butyricicoccus, Akkermansia, Blautia. Serum metabolomic profiling increased metabolites indole-3-propionic (IPA), indoleacrylic (IA), glycolithocholic (GLCA). Conclusions: attenuates oxidative stress, inflammation high-fat-diet-induced MASLD, supporting potential as probiotic candidate modulation

Language: Английский

Gut microbiota: the pathogenetic bridge between inflammatory bowel disease and metabolic-associated steatotic liver disease DOI Creative Commons
Giuseppe Guido Maria Scarlata, Ludovico Abenavoli

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: Feb. 5, 2025

Language: Английский

Citations

2
Gut microbial metabolites in MASLD: Implications of mitochondrial dysfunction in the pathogenesis and treatment DOI Creative Commons
Ruhan Zhang, Zhaobo Yan, Huan Zhong

et al.

Hepatology Communications, Journal Year: 2024, Volume and Issue: 8(7)

Published: July 1, 2024

With an increasing prevalence, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major global health problem. MASLD is well-known as multifactorial disease. Mitochondrial dysfunction and alterations in the gut bacteria are 2 vital events MASLD. Recent studies have highlighted cross-talk between microbiota mitochondria, mitochondria recognized pivotal targets of to modulate host's physiological state. plays role associated with multiple pathological changes, including hepatocyte steatosis, oxidative stress, inflammation, fibrosis. Metabolites crucial mediators that influence extraintestinal organs. Additionally, regulation composition may serve promising therapeutic strategy for This study reviewed potential roles several common metabolites MASLD, emphasizing their impact on mitochondrial function. Finally, we discuss current treatments probiotics, prebiotics, antibiotics, fecal transplantation. These methods concentrate restoring promote host health.

Language: Английский

Citations

15
Gut microbiome and metabolome signatures in liver cirrhosis-related complications DOI Creative Commons
Satya Priya Sharma, Haripriya Gupta,

Goo-Hyun Kwon

et al.

Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: 30(4), P. 845 - 862

Published: July 25, 2024

Background/Aims: Shifts in the gut microbiota and metabolites are interrelated with liver cirrhosis progression complications. However, causal relationships have not been evaluated comprehensively. Here, we identified complication-dependent metabolic signatures patients cirrhosis.Methods: Microbiome taxonomic profiling was performed on 194 stool samples (52 controls 142 patients) via V3-V4 16S rRNA sequencing. Next, 51 (17 34 were selected for fecal metabolite gas chromatography mass spectrometry liquid coupled to time-of-flight spectrometry. Correlation analyses targeting gut-microbiota, metabolites, clinical parameters, presence of complications (varices, ascites, peritonitis, encephalopathy, hepatorenal syndrome, hepatocellular carcinoma, deceased).Results: <i>Veillonella</i> bacteria, <i>Ruminococcus gnavus</i>, <i>Streptococcus pneumoniae</i> cirrhosis-related microbiotas compared control group. <i>Bacteroides ovatus, Clostridium symbiosum, Emergencia timonensis, Fusobacterium varium</i>, <i>Hungatella</i>_uc associated The areas under receiver operating characteristic curve (AUROCs) diagnosis cirrhosis, deceased 0.863, 0.733, 0.71, 0.69, respectively. AUROCs mixed microbial species complication 0.808 0.847, According profile, 5 increased biomarkers (AUROC >0.880) Clinical markers significantly correlated metabolites.Conclusions: Cirrhosis-dependent present unique that can be used as noninvasive its

Language: Английский

Citations

9
Innate immune cells link dietary cues to normal and abnormal metabolic regulation DOI
Peng Zhang, Kosuke Watari, Michael Karin

et al.

Nature Immunology, Journal Year: 2025, Volume and Issue: 26(1), P. 29 - 41

Published: Jan. 1, 2025

Language: Английский

Citations

1
Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions DOI
Xiaoyu Cai,

Fujia Ren,

Yao Yao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034

Published: Jan. 12, 2025

Language: Английский

Citations

1
Gut microbiota-derived metabolites and chronic inflammatory diseases DOI Creative Commons
Alejandra Vargas, Benjamin L. Robinson, Kevin Houston

et al.

Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

The gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption this microbial balance, known as dysbiosis, has been increasingly implicated the pathogenesis chronic inflammatory conditions, including cardiovascular, gastrointestinal, autoimmune diseases, well disorders such diabetes obesity. A crucial mechanism through which microbiota exerts its effects on host physiology is via production bioactive metabolites. These metabolites, short-chain fatty acids, bile tryptophan derivatives, are key modulating responses regulating functions. Dysbiosis disrupts function these thereby contributing to dysregulation, inflammation, disease progression. This review examines microbiota-derived metabolites with focus their immunomodulatory effects. deeper understanding mechanisms may open way for novel therapeutic strategies aimed at restoring homeostasis mitigating global burden diseases.

Language: Английский

Citations

1
Gut microbiota-derived metabolites: implications for metabolic syndrome and therapeutic interventions DOI Creative Commons
Samuel Oluwadare Olalekan, Olalekan Olanrewaju Bakare, IO Osonuga

et al.

The Egyptian Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: July 25, 2024

Abstract Background The gut microbiota (GM) and their metabolites have garnered significant attention for roles in metabolic syndrome (MetS) associated conditions. MetS, characterized by a cluster of abnormalities, significantly increases the risk cardiovascular disease (CVD), obesity, insulin resistance, type 2 diabetes mellitus (T2DM). dysbiosis microbiota, marked changes microbial composition function, has been implicated pathogenesis MetS. Main body This review synthesizes recent findings elucidating influence GM microbiota-derived on MetS progression. Notably, alterations dysregulation such as short-chain fatty acids (SCFAs), trimethylamine N-oxide (TMAO), polyamines, amino acids, indole derivatives development. These play crucial processes, imbalance can trigger or exacerbate disturbances with Various therapeutic approaches, including dietary interventions, probiotics, prebiotics, precision medicine targeting specific metabolites, offer promising strategies managing interventions aim to restore healthy balance regulate production beneficial metabolites. Conclusion complexity interactions systemic effects necessitate more standardized research methodologies. Future investigations focusing personalized non-invasive diagnostic tools are warranted address complexities management. Advancing our understanding GM-metabolite-MetS axis will be developing effective, targeted treatments improving patient outcomes

Language: Английский

Citations

5
Schisandra chinensis polysaccharide prevents alcohol-associated liver disease in mice by modulating the gut microbiota-tryptophan metabolism-AHR pathway axis DOI

Yan-Yu Chi,

Junyan Xiang,

Huimin Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136843 - 136843

Published: Oct. 1, 2024

Language: Английский

Citations

4
Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) DOI Open Access
Sevag Hamamah,

Oana C. Iatcu,

Mihai Covașă

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

Citations

4
Exploring the causal associations of the gut microbiota and plasma metabolites with ovarian cancer: an approach of mendelian randomization analysis combined with network pharmacology and molecular docking DOI Creative Commons

Junfeng Guo,

Chen Wang, He Li

et al.

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0