BMC Sports Science Medicine and Rehabilitation,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Dec. 5, 2024
Nowadays,
obesity
has
become
a
major
health
issue.
In
addition
to
negatively
affecting
body
composition
and
metabolic
health,
recent
evidence
shows
unfavorable
shifts
in
gut
microbiota
individuals
with
obesity.
However,
the
effects
of
weight
loss
on
microbes
metabolites
remain
controversial.
Therefore,
purpose
this
study
was
investigate
12-week
program
patients
We
conducted
controlled
trial
23
male
female
Twelve
participants
completed
caloric
restriction
combined
strength
HIIT
training
(INT,
pre-BMI
37.33
±
6.57
kg/m2),
eleven
were
designated
as
non-intervention
controls
(pre-BMI
38.65
8.07
kg/m2).
Metagenomic
sequencing
V3-V4
region
16S
rDNA
gene
from
fecal
samples
allowed
for
classification.
Nuclear
magnetic
resonance
spectroscopy
characterized
selected
serum
metabolite
concentrations.
Within
INT,
we
observed
significant
improvement
composition;
decrease
liver
enzymes
(AST,
ALT,
GMT);
increase
relative
abundance
commensal
bacteria
(e.g.,
Akkermansia
muciniphila,
Parabacteroides
merdae,
Phocaeicola
vulgatus);
SCFA-producing
genera
Butyrivibrio,
Coprococcus,
Blautia).
addition,
correlations
found
between
microbes,
composition,
biomarkers,
SCFAs.
Notably,
Random
Forest
Machine
Learning
analysis
identified
predictors
(Butyrivibrio
fibrisolvens,
Blautia
caecimuris,
Coprococcus
comes,
waist
circumference)
moderate
ability
discriminate
INT
subjects
pre-
post-intervention.
Our
results
indicate
that
positively
influences
microbiota,
microbial
metabolites,
demonstrating
among
these
variables.
linked
obesity,
e.g.,
muciniphila.
Additionally,
our
contributes
ongoing
debate
about
role
SCFAs
SCFA
producers
after
program.
The
registered
[05/12/2014]
ClinicalTrials.gov
(No:
NCT02325804).
Cell & Bioscience,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 12, 2025
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
chronic
and
systemic
metabolic
characterized
by
the
presence
of
hepatic
steatosis
at
least
one
cardiometabolic
risk
factor
(CMRF).
The
pathogenesis
MASLD
involves
multiple
mechanisms,
including
lipid
metabolism
disorders,
insulin
resistance,
inflammatory
responses,
hepato-intestinal
axis
dysfunction.
Among
these
factors,
diet
serves
as
both
an
inducement
potential
remedy
in
disease's
development.
Notably,
high-lipid
exacerbates
fat
accumulation,
oxidative
stress,
thereby
promoting
progression
MASLD.
Consequently,
dietary
induction
models
have
become
vital
tools
for
studying
pathological
mechanisms
MASLD,
providing
foundation
identifying
therapeutic
targets.
Additionally,
we
summarize
effects
optimization
on
elucidate
role
specific
components
regulating
axis,
metabolism,
inhibiting
responses.
In
conclusion,
studies
utilizing
animal
offer
significant
insights
into
therapy,
particularly
concerning
regulation
metabolism-related
hepatoenteric
axis-related
signaling
pathways
well
beneficial
mechanism
probiotics
regulation.
By
understanding
which
different
patterns
affect
can
assess
clinical
applicability
current
strategies
provide
new
directions
research
treatment
aimed
modification.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
growing
global
health
threat.
Human
milk
oligosaccharides
(HMOs)
exhibit
prebiotic
properties
that
may
alleviate
NAFLD
progression.
Herein,
our
study
demonstrates
3-fucosyllactose
(3-FL),
distinctive
and
crucial
HMO,
significantly
attenuates
body
weight
gain,
enhances
hepatic
lipid
metabolism,
reduces
inflammation
in
high-fat
diet
(HFD)-induced
mouse
model.
These
findings
suggest
its
potential
as
dietary
supplement
for
preventing
alleviating
Subsequently,
fecal
metagenomic
nontargeted
metabolomics
analyses
revealed
3-FL
treatment
alleviated
HFD-induced
gut
microbiota
dysbiosis,
with
specific
enhancement
of
the
pantothenate
(vitamin
B5)
metabolic
pathways.
Our
targeted
metabolite
analysis
further
significant
increase
both
concentrations,
which
contributed
to
coenzyme
A
(CoA)-mediated
metabolism
pathway.
Furthermore,
subsequent
population
cohort
correlation
between
serum
levels
progression
NAFLD,
thereby
reinforcing
candidacy
noninvasive
diagnostic
biomarker.
show
acts
an
effective
symptoms,
part
by
enhancing
microbiota-mediated
pantothenate/CoA
Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Purpose
of
review
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
highly
prevalent
condition
that
can
progress
to
fibrosis,
steatohepatitis,
and
hepatocellular
carcinoma.
This
examines
recent
advances
concerning
the
role
gut
microbiota
in
MASLD
microbiota-focused
interventions
positively
impact
outcome.
Recent
findings
Dysbiotic
compromised
barrier
facilitate
translocation
microbial-associated
molecular
patterns
harmful
metabolites
into
portal
circulation
liver,
where
they
exacerbate
inflammatory
fibrogenic
processes.
Conversely,
other
bacterial
have
protective
effects
liver.
Therefore,
homeostasis
essential
for
maintaining
health.
Summary
Levels
including
ethanol,
NH
3
,
trimethylamine-L-oxide,
2-oleylglycerol,
litocholic
acid
are
often
increased
patients
with
MASLD.
short-chain
fatty
acids,
indole
derivatives,
histidine,
acids
taurodeoxycholic,
3-succinylcholic,
hyodeoxycholic
decreased.
The
main
aim
current
interventions/treatments
reduce
increase
beneficial
ones.
These
include
drugs
(pemafibrate,
metformin,
obeticholic
acid),
natural
compounds
(silymarin,
lupeol,
dietary
fiber,
peptides),
exogenous
bacteria
(probiotics,
symbionts),
special
diets
(Mediterranean
diet,
time-restricted
feeding),
as
well
transplantation,
phage
therapy.
Most
improve
permeability,
inflammation,
fibrosis
through
regulation,
promising
alternatives
MASLFD
management.
However,
most
results
come
from
animal
studies,
while
clinical
trials
lacking.
Further
research
therefore
needed
this
area.
The Journal of Headache and Pain,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Oct. 8, 2024
Recently,
there
has
been
increasing
interest
in
the
possible
role
of
gut
microbiota
(GM)
onset
migraine.
Our
aim
was
to
verify
whether
bacterial
populations
associated
with
intestinal
dysbiosis
are
found
pediatric
patients
We
looked
for
which
metabolic
pathways,
these
bacteria
were
involved
and
they
might
be
inflammation
increased
permeability.
Journal of Animal Science and Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 29, 2024
Physiological
effects
of
polyphosphates
with
different
chain
lengths
were
unknown
in
poultry.
Broilers
used
as
experimental
subjects
to
observe
the
caused
by
SCPP
(Short
polyphosphates,
P3),
MCPP
(Medium
P14),
and
LCPP
(Long
P130).
showed
most
strong
antibacterial
activity
of
Shigella
sonnei,
Pseudomonas
aeruginosa,
Salmonella
enterica
ser.
Pullorum,
E.
coli
O157:H7.
reduces
level
triglycerides
blood
increases
length
jejunum.
Intervention
induced
cecum
IL-1β
expression
involved
regulation
autoimmune
inflammation.
In
cecum,
increased
number
Lactobacilli
while
significantly
decreasing
Shigella,
SalmonellaColiform
bacteria.
SCPP,
MCPP,
improved
intestinal
microflora
abundance
beneficial
bacteria
such
Faecalibacterium,
Phocaeicola,
and
Barnesiella
but
reduced
Bacteroides.
addition,
did
not
adversely
affect
meat
quality
broilers.
The
antimicrobial
properties
can
help
improve
environment
enhance
immune
properties.
Based
on
comparison
broiler
chickens,
it
is
suggested
that
more
effective
compared
feed
additives.
Foods,
Journal Year:
2024,
Volume and Issue:
14(1), P. 6 - 6
Published: Dec. 24, 2024
The
increasing
global
population
and
the
environmental
consequences
of
meat
consumption
have
led
to
exploration
alternative
sources
protein.
Edible
insects
gained
attention
as
a
sustainable
nutritionally
rich
alternative.
We
investigated
effects
two
commonly
consumed
insects,
Protaetia
brevitarsis
seulensis
larva
Bombyx
mori
pupa,
on
beneficial
gut
microbiota
growth,
using
whole
16s
metagenome
sequencing
assess
diet-associated
changes.
Seven-week-old
female
C57BL/6J
mice
were
administered
edible
along
with
fracto-oligosaccharide
(FOS)
positive
control
sham
(phosphate
buffer
saline
(PBS))
negative
control,
relative
abundance
insect-diet-associated
microbes.
In
total,
567
genera
470
species
observed,
among
these,
15
bacterial
differentially
abundant
in
all
three
groups.
These
results
show
that
pupa
polysaccharides
greater
ability
regulate
probiotics
next-generation
probiotics.
particular,
Lactococcus
garvieae,
which
has
promising
gastrointestinal
tracts
humans
animals,
was
significantly
enriched
both
polysaccharides,
similar
fracto-oligosaccharide.
suggest
these
particularly
can
enhance
growth
microbes,
potentially
leading
improved
overall
health
healthy
populations.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 17, 2024
Abstract
Object:
To
observe
the
impact
of
artificial
liver
support
system
(ALSS)
on
intestinal
microbiota
and
serum
bile
acid
(BA)
profiles
in
patients
with
acute-on-chronic
failure
(ACLF),
to
investigate
correlation
between
microbiota,
BA
profiles,
clinical
outcomes
ACLF
patients.
Methods
A
prospective
study
was
conducted
include
51
diagnosed
ACLF.
These
were
stratified
into
two
groups
based
utilization
ALSS
during
their
treatment
period:
a
standard
medical
group
(SMT
group)
comprising
19
an
combined
SMT
(ALSS
encompassing
32
Blood
stool
samples
collected
from
day
admission
14
days
after
treatment.
Additionally,
8
healthy
controls
recruited,
collected.
The
sequenced
using
16S
rRNA
sequencing
technique,
determined
ultra-performance
liquid
chromatography/mass
spectrometry.
Results
exhibited
imbalances
abnormalities
profiles.
Compared
alone,
is
more
effective
regulating
imbalance
increasing
concentrations
ursodeoxycholic
glycoursodeoxycholic
acid.
There
significant
presence
FaecalibaculumGemmiger,
as
well
taurochenodeoxycholic
acid,
being
associated
Conclusions
Our
identified
compositional
characteristics
patients,
emphasizing
both
BMC Sports Science Medicine and Rehabilitation,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Dec. 5, 2024
Nowadays,
obesity
has
become
a
major
health
issue.
In
addition
to
negatively
affecting
body
composition
and
metabolic
health,
recent
evidence
shows
unfavorable
shifts
in
gut
microbiota
individuals
with
obesity.
However,
the
effects
of
weight
loss
on
microbes
metabolites
remain
controversial.
Therefore,
purpose
this
study
was
investigate
12-week
program
patients
We
conducted
controlled
trial
23
male
female
Twelve
participants
completed
caloric
restriction
combined
strength
HIIT
training
(INT,
pre-BMI
37.33
±
6.57
kg/m2),
eleven
were
designated
as
non-intervention
controls
(pre-BMI
38.65
8.07
kg/m2).
Metagenomic
sequencing
V3-V4
region
16S
rDNA
gene
from
fecal
samples
allowed
for
classification.
Nuclear
magnetic
resonance
spectroscopy
characterized
selected
serum
metabolite
concentrations.
Within
INT,
we
observed
significant
improvement
composition;
decrease
liver
enzymes
(AST,
ALT,
GMT);
increase
relative
abundance
commensal
bacteria
(e.g.,
Akkermansia
muciniphila,
Parabacteroides
merdae,
Phocaeicola
vulgatus);
SCFA-producing
genera
Butyrivibrio,
Coprococcus,
Blautia).
addition,
correlations
found
between
microbes,
composition,
biomarkers,
SCFAs.
Notably,
Random
Forest
Machine
Learning
analysis
identified
predictors
(Butyrivibrio
fibrisolvens,
Blautia
caecimuris,
Coprococcus
comes,
waist
circumference)
moderate
ability
discriminate
INT
subjects
pre-
post-intervention.
Our
results
indicate
that
positively
influences
microbiota,
microbial
metabolites,
demonstrating
among
these
variables.
linked
obesity,
e.g.,
muciniphila.
Additionally,
our
contributes
ongoing
debate
about
role
SCFAs
SCFA
producers
after
program.
The
registered
[05/12/2014]
ClinicalTrials.gov
(No:
NCT02325804).
