Effects of different levels of synbiotic administration on growth performance and response to post-hatch necrotic enteritis in Cobb-500 broilers DOI Creative Commons
Arjun Acharya, Bhuminand Devkota, Hom Bahadur Basnet

et al.

Discover Life, Journal Year: 2024, Volume and Issue: 54(1)

Published: Nov. 22, 2024

The poultry sector worldwide faces low productivity and struggles for the control of enteric disorders such as necrotic enteritis (NE), despite its demand. experiments were carried out on Cobb-500 broilers to assess effects various levels synbiotic (recommended level, 25% 50% higher than recommended) growth performance intestinal lesions. chicks divided into three treatment groups a group in initial trial. second trial included ovo normal with varying through feed. Coccivac D2®, commercial vaccine, was administered at concentrated dose (10 times higher) initiate NE. results showed that increased up suggested significantly weight gain. feed conversion ratio noticeably greater during final 2 weeks. supplemented had reduced scores lesions, suggesting protection against Increased have been shown improve reduce Furthermore, these highlighted potential promoter play protective role However, more research is necessary fully understand consequences expenses associated broilers.

Language: Английский

How can the gut microbiome be targeted to fight multidrug-resistant organisms? DOI Creative Commons
Benjamin Davido, Blair Merrick, Ed J. Kuijper

et al.

The Lancet Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 101063 - 101063

Published: Feb. 1, 2025

The rise of antimicrobial resistance presents a challenge to public health, undermines the efficacy antibiotics, and compromises management infectious diseases. Gut colonisation by multidrug-resistant organisms, such as Enterobacterales vancomycin-resistant enterococci, is associated with increased morbidity mortality rates, well health-care costs. Of late, role gut microbiome in combating which could precede invasive infection, has garnered interest. Innovative interventions, including faecal microbiota transplantation, probiotics, phage therapy, bacterial consortia, represent potential preventive or therapeutic options counteract organisms. In this Personal View, we have synthesised current findings on these interventions elucidated their solutions crisis resistance.

Language: Английский

Citations

3
Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance DOI Creative Commons
Lingping Zhu, Xuefeng Yang

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 603 - 626

Published: Feb. 1, 2025

Abstract: The intestinal microecology is comprises microorganisms and other components constituting the entire ecosystem, presenting characteristics of stability dynamic balance. Current research reveals microecological imbalances are related to various diseases. However, fundamental clinical applications have not been effectively integrated. Considering importance complexity regulating balance, this study provides an overview high-risk factors affecting detection methods. Moreover, it proposes definition imbalance definition, formulation, outcomes gut prescription facilitate its application in practice, thus promoting on improving quality life population. Keywords: microecology, risk, prescription, faecal microbiota transplantation

Language: Английский

Citations

2
Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children DOI Creative Commons
Yali Zhang, Yingying Xu, Ling Hu

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 6, 2025

Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis contributing factors not yet fully elucidated. Probiotics have recently emerged as promising agents for modulating intestinal microecology gained considerable attention clinical research on preventing treating RRTIs children. This article provides an initial overview the concept, classification, mechanisms underlying probiotics. It emphasizes beneficial effects health by microbial equilibrium, augmenting immune system functionality, attenuating inflammatory responses. Subsequently, we examine existing regarding use probiotics pediatric RRTIs. Numerous trials unequivocally demonstrated that supplementing with can reduce both frequency severity children while also simultaneously decreasing antibiotic usage. However, there ongoing controversies challenges current concerning influence probiotic type, dosage, duration use, other efficacy. Furthermore, variations been observed across different studies. Additionally, it is crucial to further evaluate safety potential long-term side associated In conclusion, propose future directions including conducting more high-quality randomized controlled optimize application strategies alongside treatments considering based age conditions among populations. Finally, summary although exhibit benefits children; additional studies necessary refine ensuring effectiveness.

Language: Английский

Citations

1
The Microbial Perspective: A Systematic Literature Review on Hypertension and Gut Microbiota DOI Open Access

Alexandros Tsiavos,

Christina Antza, Christina Trakatelli

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3698 - 3698

Published: Oct. 30, 2024

Background: Understanding the causes of hypertension is important in order to prevent disease. Gut microbiota (GM) seems play an role, but detailed physiology remains elusive, with alpha diversity being most studied indicator. Objectives: This review aimed systematically synthesize data on gut (alpha diversity) and hypertension. Methods: Databases, including MEDLINE/PubMed, Scopus, EMBASE, citations were queried. We retrieved articles reporting association between A valid critical appraisal tool was also used investigate quality included studies. Results: Eighteen eligible studies met our inclusion criteria. In this report, we focused following indices diversity: Shannon, Chao1, Simpson, Abundance-based Coverage Estimator (ACE) indices. Several observed a significantly lower Shannon index hypertensive patients compared healthy control group. Nevertheless, no statistically significant difference found for ACE controls. higher Firmicutes-to-Bacteroidetes ratio (F/B ratio) consistently controls, indicating potential dysbiosis microbiota. Conclusions: Our systematic indicates that may exhibit imbalance microbiota, evidenced by decreased elevated F/B ratio. However, absence differences secondary (Chao1, ACE) highlights need further research. Well-designed, large-scale are necessary clarify these associations explore role development.

Language: Английский

Citations

6
The Complex Relationship Between Gut Microbiota and Alzheimer’s Disease: A Systematic Review DOI Creative Commons

Xuan-Peng Zhou,

Lei Sun, Wenhao Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102637 - 102637

Published: Dec. 1, 2024

Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system. Despite extensive research conducted on this disorder, its precise pathogenesis remains unclear. In recent years, microbiota-gut-brain axis has attracted considerable attention within field AD. The gut microbiota communicates bidirectionally with system through gut-brain axis, and alterations in structure function can influence progression Consequently, regulating to mitigate AD emerged as novel therapeutic approach. Currently, numerous studies concentrate intrinsic relationship between paper, we summarize multifaceted role present detailed strategies targeting microbiota, including treatment Traditional Chinese Medicine (TCM), which garnered increasing years. Finally, discuss potential for modulating alleviate AD, current challenges area research, provide an outlook future directions field.

Language: Английский

Citations

4
Probiotic Potential and Bioactive Properties of Lactococcus lactis MSH-08 Isolates from Fermented Dairy Products: Antimicrobial, Antioxidant, and Anticancer Activities DOI Creative Commons

Salah E. Maaty,

Mohamed M. A. Elashtokhy,

Mamdouh K. Amin

et al.

Applied Food Research, Journal Year: 2025, Volume and Issue: 5(1), P. 100763 - 100763

Published: Feb. 11, 2025

Language: Английский

Citations

0
Five-Day Treatment with B. licheniformis Along with Classical Vancomycin Treatment Was Effective in Preserving Gut Microbiota in Patients with Clostridioides difficile Infection DOI Open Access
Tae‒Geun Gweon, Sang‐Bum Kang, Soo‐Young Na

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 641 - 641

Published: Feb. 11, 2025

Background/Objectives:Clostridioides difficile infection (CDI) is an important nosocomial diarrheal disease. The benefits of the probiotic Bacillus licheniformis (B. licheniformis) in preservation intestinal microbiota have not been studied patients with CDI to date. Therefore, we aimed investigate efficacy B. preserving CDI. Methods: A multicenter, randomized, placebo-controlled trial was carried out at six academic centers Korea. Individuals diagnosed mild moderate were included this trial. treated vancomycin 125 mg four times daily for two weeks. Along vancomycin, administered five days study, while a placebo given group. Microbiome analysis performed before and after administering or placebo, using 16S rRNA amplicon sequencing. Alpha beta diversity compared between groups. Results: total 35 participants finally 16 study group 19 alpha similar both groups treatment. After administration did decrease (Chao1 index, p = 0.665; observed features, 0.692). In contrast, decreased 0.011; 0.011). Beta differ Conclusions: addition effective gut

Language: Английский

Citations

0
Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria DOI Creative Commons
Wenwen Ding, Yiwen Cheng, Xia Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Antimicrobial resistance (AMR) has become a major and escalating global health threat, undermining the effectiveness of current antibiotic antimicrobial therapies. The rise multidrug-resistant bacteria led to increasingly difficult-to-treat infections, resulting in higher morbidity, mortality, healthcare costs. Tackling this crisis requires development novel agents, optimization therapeutic strategies, initiatives infection surveillance control. Recent studies highlight crucial role human gut microbiota defending against AMR pathogens. A balanced protects body through mechanisms such as colonization resistance, positioning it key ally fight AMR. In contrast, dysbiosis disrupts defense, thereby facilitating persistence, colonization, dissemination resistant This review will explore how influence drug-resistant bacterial its involvement various types AMR-related potential for microbiota-targeted therapies, fecal transplantation, prebiotics, probiotics, phage therapy. Elucidating interactions between pathogens provide critical insights developing strategies prevent treat infections. While previous reviews have focused on general impact health, specifically look at latest research evolution spread AMR, highlighting strategies.

Language: Английский

Citations

0
Granola consumption with multiple prebiotics in Japanese participants increases Bifidobacterium abundance and improves stress and subjective sleepiness DOI Creative Commons
Hiroyuki Sasaki,

Hirofumi Masutomi,

Shuji Nakamura

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 20, 2025

Background Sleep is essential for physical and mental health. However, stress-related sleep disorders are common in Japan, the gut–brain axis may play a role stress management. This study investigated whether consumption of granola containing multiple prebiotic ingredients could alleviate improve insomnia adults with problems, regardless individual differences gut microbiota. Additionally, we aimed to investigate relationship between changes microbiota observed improvements. Method A single-arm uncontrolled trial was conducted 27 high levels disturbance. The participants consumed 50 g prebiotics-containing daily 8 weeks. Subjective quality assessed using Athens Insomnia Scale, Epworth Oguri-Shirakawa-Azumi Inventory-Middle-aged Aged version (OSA-MA). Stress were by administering Brief Job Questionnaire Profile Mood States 2nd edition (POMS2). Gut composition analyzed 16S rDNA sequencing. Results After weeks, subjective scores onset maintenance improved significantly, whereas mood disturbance decreased significantly. analysis showed that relative abundance Bifidobacterium increased, Bacteroides decreased. Correlation suggested significant association increased level reduced ( r = −0.39, p 0.0035) −0.3, 0.026). Conclusion Prebiotics-containing disturbances, which be attributed alterations microbiota, particularly increase abundance.

Language: Английский

Citations

0
Role of gut microbiome in suppression of cancers DOI Creative Commons
Yao Xu, Zhaoyu Gao, Jiaying Liu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 20, 2025

The pathogenesis of cancer is closely related to the disruption homeostasis in human body. gut microbiome plays crucial roles maintaining its host throughout lifespan. In recent years, a large number studies have shown that dysbiosis involved entire process initiation, development, and prognosis by influencing immune system metabolism. Some specific intestinal bacteria promote occurrence development cancers under certain conditions. Conversely, some other suppress oncogenesis progression cancers, including inhibiting delaying boosting therapeutic effect on cancers. promoting effects been comprehensively discussed previous review. This article will review latest advances mechanisms suppression, providing new perspective for developing strategies prevention treatment.

Language: Английский

Citations

0