Celiac Disease, Gluten-Free Diet, and Eating Disorders: From Bench to Bedside DOI Creative Commons
Yaohui Wei, Yating Wang, Yonggui Yuan

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 74 - 74

Published: Dec. 31, 2024

Celiac disease (CD) and eating disorders (EDs) are complex chronic conditions in adolescents, sharing symptoms such as weight change, malnutrition, gastrointestinal symptoms. CD, an autoimmune disorder triggered by gluten ingestion, is managed through a strict gluten-free diet that can unintentionally foster disordered behaviors due to dietary restrictions. Conversely, EDs may mask complicate CD symptoms, leading diagnostic delays treatment challenges. Evidence reveals increased risk of individuals vice versa, indicating potential bidirectional relationship. This review explores the mechanisms clinical implications this interplay proposes integrated screening care strategies improve quality life for with both conditions.

Language: Английский

Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders DOI Creative Commons
Sabrina J. P. Huwart, Nuria Morales‐Puerto, Amandine Everard

et al.

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333397

Published: Feb. 17, 2025

The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific investigation. complex ecosystem microorganisms in the influences host metabolism, immune function neurobehavioural signalling. This review explores role neuroinflammation dysregulations food-induced reward signalling potential causal microbiota on these proinflammatory processes. Particular attention given to disorders (ED, specifically anorexia nervosa, binge disorder bulimia nervosa) links with microbiota, alterations neuroinflammation. Finally, we propose modulation as promising therapeutic strategy ED.

Language: Английский

Citations

2
Vitamin D3 affects the gut metabolomics in lipopolysaccharide-injected mice DOI Creative Commons

Qian Xu,

Qi Geng, Yuan Liu

et al.

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Background: Although vitamin D3 (VD3) may regulate gut microbiota to play protective roles in systemic inflammation, its effects on metabolomics have not been clarified. Objective: To investigate the of VD3 LPS-injected mice. Methods: After mice were intervened with VD3, colon contents collected for an untargeted analysis, morphology and permeability epithelium illustrated. Results: The results confirmed against inflammatory changes hyperpermeability In metabolomic analysis contents, principal component showed valid data. Both partial least squares-discriminant (PLS-DA) orthogonal PLS-DA (OPLS-DA) intergroup separation samples between control Similarly, affected metabolite profiling composition mice, which also shown by OPLS-DA. Furthermore, differential metabolites identified univariate statistical analysis. For LPS stimulation, changed obviously, such as some lipid-related appeared increase. However, treatment had distinctive metabolomics, especially induced appearance Soyasaponins, reduction metabolites. Conclusions: alleviated injuries

Language: Английский

Citations

0
Gut Microbiota Regulates Food Intake in a Rodent Model of Intermittent Limited Access to Palatable Food DOI Creative Commons

Thomas Demangeat,

Léa Loison,

Marion Huré

et al.

International Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

ABSTRACT Objective Binge‐eating disorder is characterized by recurrent episodes of consumption large amounts food within a short period time, without compensatory purging behaviors. This disease major public health issue and associated with numerous comorbidities, encompassing anxiety depression. The gut microbiota has been proposed to be an important player in the onset or maintenance eating disorders. Here, we aim better delineate potential role binge‐eating disorder. Method We used model intermittent limited access palatable where eight‐week‐old C57Bl/6 female mice had during 2 h, every days over 10‐day period, high‐fat/high‐sucrose diet. Half animals received antibiotics deplete their microbiota. Eating behavior other behavioral parameters were compared between groups. Results observed increase intake as well tachyphagia demonstrate that depletion further increases these promotes behavior. No impact on depressive‐like was animals. Discussion These results show involved control binge‐eating. strengthens bacteria interest therapeutic strategies aiming at modulating patients' treat this

Language: Английский

Citations

2
A Role for the Microbiota‐Gut‐Brain Axis in Avoidant/Restrictive Food Intake Disorder: A New Conceptual Model DOI Creative Commons
Elizabeth M. Schneider, Ricarda Schmidt, John F. Cryan

et al.

International Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 57(12), P. 2321 - 2328

Published: Nov. 14, 2024

Avoidant/restrictive food intake disorder (ARFID) is an eating characterized by a severely restrictive diet leading to significant physical and/or psychosocial sequelae. Largely owing the phenotypic heterogeneity, underlying pathophysiological mechanisms are relatively unknown. Recently, communication between microorganisms within gastrointestinal tract and brain-the so-called microbiota-gut-brain axis-has been implicated in pathophysiology of disorders. This Spotlight review sought investigate conceptualize possible ways that axis involved ARFID drive future research this area.

Language: Английский

Citations

1
Gut microbiota regulates food intake in a rodent model of binge-eating disorder DOI

Thomas Demangeat,

Léa Loison,

Marion Huré

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Abstract Objective Binge-eating disorder is characterized by recurrent episodes of consumption large amounts food within a short period time, without compensatory behaviours. This disease major public health issue since it decreases patients quality life and associated with numerous comorbidities, encompassing anxiety, depression complications obesity. The pathophysiology binge-eating complex involves both endogenous, environmental sociocultural factors. gut microbiota has been proposed to be an important player in the onset or maintenance eating disorders. Here, we aim better delineate potential role disorder. Method We used model where eight-weeks-old C57Bl/6 female mice had access during 2 hours, every days over 10-day period, highly palatable high-calorie diet. Half animals received antibiotics deplete their microbiota. Eating behaviour other behavioural parameters were compared between groups. Results observed increase intake mouse exposed high-fat high-sucrose diet, as well tachyphagia craving for episodes. demonstrate depletion further increases intake, specifically Discussion These results show that involved control binge-eating. strengthens bacteria open way future therapeutic strategies aiming at targeting patients’

Language: Английский

Citations

0
Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis DOI Creative Commons
Yufei Wang, Tao Xu, Yuexian Tao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 10, 2024

Background Eating disorders are illnesses that can seriously impair the health and wellbeing of patients. Written emotional disclosure has been recognized as a therapeutic technique may be helpful in aiding patients’ psychological adjustment. However, it is unclear what favorable effects eating disorder patients derive from written therapy. This study aimed to review effectiveness treating using systematic meta-analysis. Objective was examine validity intervention for well provide guidelines management Methods Researchers independently developed inclusion exclusion criteria according PICOS principle systematically searched English literature databases such PubMed, Medline, Web Science, Cochrane Library, CINAHL, EBSCO, Embase, so on, time library construction December 2023. Risk Bias version 2 (RoB 2) used evaluate studies included this review. All were randomized controlled trials. Accurate information extracted then subjected meta-analysis with Review Manager 5.4 software. The credibility evidence assessed GRADEprofiler 3.6 Results final analysis 13 trials involving 1,444 participants. decrease symptoms scores (SMD = −0.20, 95% CI [−0.34, −0.05], Z 2.59, p 0.01), body dissatisfaction 0.37, [0.21, 0.52], 4.59, < 0.001), thin ideal internalization score 0.42, [0.22, 0.62], 4.12, 0.001). Anxiety (MD 0.43, [−0.77, 1.63], 0.70, 0.48), depression −0.66, [−1.78, 0.47], 1.14, 0.25) negative affect 0.51, [−0.24, 1.27], 1.33, 0.18), no statistically significant differences. Conclusion In conclusion, analyzed existing showed effective alleviating image problems, but there insufficient depression, anxiety, affect. limited. Therefore, more research needed future further enrich field disorders. Systematic registration https://www.crd.york.ac.uk/prospero/ ,CRD42023445577.

Language: Английский

Citations

0
Celiac Disease, Gluten-Free Diet, and Eating Disorders: From Bench to Bedside DOI Creative Commons
Yaohui Wei, Yating Wang, Yonggui Yuan

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 74 - 74

Published: Dec. 31, 2024

Celiac disease (CD) and eating disorders (EDs) are complex chronic conditions in adolescents, sharing symptoms such as weight change, malnutrition, gastrointestinal symptoms. CD, an autoimmune disorder triggered by gluten ingestion, is managed through a strict gluten-free diet that can unintentionally foster disordered behaviors due to dietary restrictions. Conversely, EDs may mask complicate CD symptoms, leading diagnostic delays treatment challenges. Evidence reveals increased risk of individuals vice versa, indicating potential bidirectional relationship. This review explores the mechanisms clinical implications this interplay proposes integrated screening care strategies improve quality life for with both conditions.

Language: Английский

Citations

0