Current Radiopharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 30 - 37
Published: Oct. 25, 2023
Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (
Language: Английский
Cancers, Journal Year: 2023, Volume and Issue: 15(13), P. 3298 - 3298
Published: June 22, 2023
Accumulating evidence supports that both long non-coding and micro RNAs (lncRNAs miRNAs) are implicated in glioma tumorigenesis progression. Poor outcome of gliomas has been linked to late-stage diagnosis mostly ineffectiveness conventional treatment due low knowledge about the early stage gliomas, which not possible observe with diagnostic approaches. The past few years witnessed a revolutionary advance biotechnology neuroscience understanding tumor-related molecules, including involved angiogenesis progression cells thus used as prognostic biomarkers well novel therapeutic targets. emerging research on lncRNAs miRNAs highlights their crucial role progression, offering new insights into disease. These hold significant potential targets, paving way for innovative approaches against glioma. This review encompasses comprehensive discussion gene regulation is responsible promotion or inhibition collects existing links between these key cancer-related molecules.
Language: Английский
Citations
19
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131048 - 131048
Published: March 23, 2024
Language: Английский
Citations
4
Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111620 - 111620
Published: Jan. 21, 2025
Language: Английский
Citations
0
Animal Cells and Systems, Journal Year: 2025, Volume and Issue: 29(1), P. 135 - 148
Published: Feb. 11, 2025
Circadian rhythms are 24-hour cycles in various biological processes, such as sleep, wake, and hormone secretion, controlled by an internal clock. Disruption of circadian has been related to human diseases. Abnormal expression rhythm-related genes, CLOCK, BMAL1, PER1, PER2, CRY1, CRY2, RORα, NPAS2, REV-ERBα TIMELESS also reported be associated with cancer. NPAS2 cancer development. In contrast, RORα inhibit development progression. Furthermore, studies suggest that genes can regulated ncRNAs miRNAs, lncRNAs circRNAs dysregulation these contributes Here, we summarize the mechanisms whereby ncRNA leads abnormal several cancers gene-associated regulatory contribute resistance chemo – radiotherapy. This review provides insights into mechanistic involvements network
Language: Английский
Citations
0
BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)
Published: Sept. 4, 2023
Abstract Background Non-small cell lung cancer (NSCLC) is the most common type of and has a poor prognosis. Identifying biomarkers based on molecular mechanisms critical for early diagnosis, timely treatment, improved prognosis cancer. MALAT1 been reported to have overexpressed tumor-promoting functions in NSCLC. It proposed as potential biomarker diagnosis Therefore, this study was conducted profile changes gene expression according regulation NSCLC lines investigate correlation through bioinformatic analysis differentially expressed genes (DEGs). Methods levels were measured using RT-qPCR. The biological analyzed by counting, colony forming, wound-healing, Transwell invasion assays. In addition, profiling response knockdown transcriptome sequencing, regulated performed GO KEGG pathway enrichment analyses. Bioinformatic databases used overall survival analysis. Results Comparative versus MRC5 cells (a normal line) three showed that significantly higher cells. decreased survival, proliferation, migration, all lines. RNA-seq DEGs 198 upregulated 266 downregulated Survival these OncoLnc database resulted selection five DEGs, phosphoglycerate mutase 1 ( PGAM1 ), 4 PGAM4 nucleolar protein 6 NOL6 nucleosome assembly like 5 NAP1L5 sestrin1 SESN1 ). selected proved TNMplot database. Conclusion might function an oncogene enhances formation, invasion. analyses , which found be closely related patient tumorigenesis. We believe further investigation will provide valuable information oncogenic role
Language: Английский
Citations
10
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: July 2, 2024
Glioblastoma poses a formidable challenge among primary brain tumors: its tumorigenic stem cells, capable of self-renewal, proliferation, and differentiation, contribute substantially to tumor initiation therapy resistance. These glioblastoma cells (GSCs), resembling conventional progenitor adopt pathways critical for tissue development repair, promoting uninterrupted expansion. Long non-coding RNAs (lncRNAs), substantial component the human transcriptome, have garnered considerable interest their pivotal roles in normal physiological processes cancer pathogenesis. They display cell- or tissue-specific expression patterns, extensive investigations highlighted impact on regulating GSC properties cellular thus offering promising avenues therapeutic interventions. Consequently, lncRNAs, with ability exert regulatory control over progression, emerged as targets innovative therapies. This review explores notable examples GSC-associated lncRNAs elucidates functional driving progression. Additionally, we delved deeper into utilizing 3D
Language: Английский
Citations
2
Mini-Reviews in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(8), P. 786 - 792
Published: Oct. 15, 2023
Long noncoding RNAs (lncRNAs) represent a large subgroup of RNA transcripts that lack the function coding proteins and may be essential universal genes involved in carcinogenesis metastasis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNAMALAT1) is overexpressed various human tumors, including gliomas. However, biological molecular mechanism action lncRNA-MALAT1 gliomas have not yet been systematically elucidated. Accumulating evidence suggests abnormal expression associated with physical properties glioma, such as tumor growth, metastasis, apoptosis, drug resistance, prognosis. Furthermore, lncRNAs, progression prognostic markers gliomas, affect tumorigenesis, proliferation glioma stem cells, resistance. In this review, we summarize knowledge on functions value This mini-review aims to deepen understanding novel potential therapeutic target for individualized precision treatment
Language: Английский
Citations
5
OncoTargets and Therapy, Journal Year: 2024, Volume and Issue: Volume 17, P. 371 - 381
Published: May 1, 2024
MCM5 is a DNA licensing factor involved in cell proliferation and has been previously established as an excellent biomarker number of malignancies. Nevertheless, the role GBM not fully clarified. The present study aimed to investigate potential roles treatment elucidate its underlying mechanism, which beneficial for developing new therapeutic strategies predicting prognosis.
Language: Английский
Citations
1
Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 216 - 227
Published: May 18, 2024
Tyrosine kinase inhibitors (TKIs) have emerged as a potential treatment strategy for glioblastoma multiforme (GBM). However, their efficacy is limited by various drug resistance mechanisms. To devise more effective treatments GBM, genetic characteristics must be considered in addition to pre-existing treatments. We performed an integrative analysis with heterogeneous GBM datasets of genomic, transcriptomic, and proteomic data from DepMap, TCGA CPTAC. found that poor prognosis was induced co-upregulation heat shock protein family A member 5 (HSPA5) fibroblast growth factor receptor 1 (FGFR1). Co-up regulation these two genes could regulate the PI3K/AKT pathway. cell lines showed higher sensitivity PI3K inhibitors. In mesenchymal subtype, FGFR1 HSPA5 resulted most malignant subtype GBM. Furthermore, we this newly discovered correlated homologous recombination deficiency (HRD) conclusion, novel druggable candidates within group exhibiting suggest strategies combination therapy.
Language: Английский
Citations
1
Animal Cells and Systems, Journal Year: 2023, Volume and Issue: 27(1), P. 309 - 320
Published: Nov. 21, 2023
The Hippo signaling pathway is a conserved that regulates cell proliferation, apoptosis, and differentiation plays essential roles in the maintenance of organ size tissue homeostasis. Also, this critical regulator malignant progression wide range cancers. Furthermore, it has been established YAP TAZ are major effectors transcription co-activators regulate expressions genes involved growth differentiation. Long non-coding RNAs (lncRNAs) transcripts longer than 200 nucleotides several biological processes, including chromatin remodeling, transcriptional regulation, post-transcriptional processing. Evidence suggests aberrant expression dysregulation lncRNAs contribute to development various malignancies by acting as oncogenes or tumor suppressors. In addition, many studies have shown can directly indirectly Hippo-YAP/TAZ cancer. Here, we overview played with focus on their regulation discuss potential usages clinical biomarkers therapeutic targets.
Language: Английский
Citations
3