Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: June 12, 2024
Atherosclerosis
(AS)
is
a
complex
disease
caused
by
multiple
pathological
factors
threatening
human
health-the
pathogenesis
yet
to
be
fully
elucidated.
In
recent
years,
studies
have
exhibited
that
the
onset
of
AS
closely
involved
with
oral
and
gut
microbiota,
which
may
initiate
or
worsen
atherosclerotic
processes
through
several
mechanisms.
As
for
how
two
microbiomes
affect
AS,
existing
mechanisms
include
invading
plaque,
producing
active
metabolites,
releasing
lipopolysaccharide
(LPS),
inducing
elevated
levels
inflammatory
mediators.
Considering
possible
profound
connection
between
effect
interaction
on
initiation
progression
has
been
investigated.
Findings
are
microbiota
can
lead
dysbiosis,
exacerbate
intestinal
inflammation.
Nevertheless,
relevant
research
not
commendably
refined
concrete
review
needed.
Hence,
in
this
review,
we
summarize
most
illustrate
an
overview
current
clinical
epidemiological
evidence
support
bidirectional
AS.
World Journal of Hepatology,
Journal Year:
2024,
Volume and Issue:
16(5), P. 688 - 702
Published: May 22, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
encompasses
a
spectrum
of
disorders
varying
severity,
ultimately
leading
to
fibrosis.
This
primarily
consists
NAFL
and
non-alcoholic
steatohepatitis.
The
pathogenesis
NAFLD
is
closely
associated
with
disturbances
in
the
gut
microbiota
impairment
intestinal
barrier.
Non-gut
commensal
flora,
particularly
bacteria,
play
pivotal
role
progression
NAFLD.
Notably,
Frontiers in Oral Health,
Journal Year:
2024,
Volume and Issue:
5
Published: Oct. 24, 2024
Cerebrovascular
stroke,
a
leading
cause
of
global
morbidity
and
mortality,
is
influenced
by
several
modifiable
risk
factors
such
as
hypertension,
diabetes,
smoking.
Emerging
evidence
highlights
the
significant
role
inflammation
in
stroke
pathogenesis,
with
conditions
like
periodontitis
potentially
exacerbating
this
risk.
The
aim
systematic
review
was
to
identify
quantify
real
impact
periodontal
disease
individuals
cerebral
through
analysis
inflammatory
indices.
Frontiers in Oral Health,
Journal Year:
2025,
Volume and Issue:
6
Published: Feb. 7, 2025
Childhood
stunting,
defined
as
impaired
linear
growth
and
development,
remains
a
significant
global
health
challenge
with
long-term
consequences
on
cognitive
physical
well-being.
Emerging
evidence
highlights
the
pivotal
role
of
oral
microbiome-a
dynamic
microbial
ecosystem-in
influencing
nutritional
status,
immune
response,
overall
systemic
health.
This
review
explores
intricate
interplay
between
microbiome
emphasizing
mechanisms
such
dysbiosis,
its
impact
nutrient
absorption,
modulation.
Disruptions
in
can
lead
to
malabsorption
inflammation,
further
exacerbating
impairments
children.
Furthermore,
potential
for
microbiome-targeted
diagnostics
interventions,
including
probiotics
prebiotics,
offers
novel
strategies
address
stunting.
A
deeper
understanding
these
interactions
may
inform
innovative
diagnostic
tools
therapeutic
interventions
aimed
at
mitigating
stunting
through
Integrating
research
into
prevention
efforts
could
provide
valuable
insights
public
improve
child
particularly
resource-limited
settings.
Future
should
focus
elucidating
molecular
pathways
linking
developing
personalized
that
optimize
early
life.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Feb. 24, 2025
Microorganisms
contribute
to
the
pathogenesis
of
obesity,
while
more
studies
focus
on
gut
microbiome.
However,
relationship
between
oral
microbiota
and
obesity
has
yet
be
elucidated.
This
study
was
designed
investigate
similarities
differences
in
effects
a
high-fat
diet
salivary
through
mouse
experiments,
exploring
hypothesis
that
microbial
mechanisms
may
obesity.
An
obese
model
established
male
C57BL/6J
mice
by
feeding
diet,
confirmed
body
weight
records
blood
glucose
tests.
evaluated
physiological
mice.
16S
rRNA
sequencing
technology
used
analyze
changes
microbiota,
gas
chromatography-mass
spectrometry
employed
evaluate
17
short-chain
medium-chain
fatty
acids
quantitatively.
The
distribution
different
(HFD)
normal
chow
(NCD)
groups.
At
genus
level
Streptococcus
Escherichia
were
highly
abundant
HFD
group.
Rodentibacter
Turicibacter
NCD
Regarding
microbiome,
diversity
are
significant
than
those
microbiota.
group
had
significantly
higher
abundance
Kineothrix,
Cryptobacteroides,
lower
CAG-485.
Nine
genera
consistent
alterations
among
which
Akkermansia,
Lactobacillus,
Intestinimonas
correlated
with
indicators,
Muribaculum
increased
decanoic
acid
levels
dysregulated
nine
associated
upregulation
certain
metabolic
pathways
group,
including
pentose
phosphate,
bacterial
invasion
epithelial
cells,
steroid
biosynthesis
pathways.
There
Certain
oral-gut
axis
altered
consistently
affect
involving
inflammation.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 338 - 338
Published: Feb. 26, 2025
Extra
virgin
olive
oil
(EVOO)
with
a
high
content
of
polyphenols
has
attracted
attention
due
to
its
proved
beneficial
effects
in
decreasing
the
risk
cardiovascular
disease,
modulating
cholesterol
levels
(HDL
and
LDL),
inflammatory
markers,
haemoglobin1Ac,
suggesting
that
EVOO
can
have
an
impact
glycemia
regulation.
This
study
assessed
consumption
northern
Portuguese
polyphenol-rich
profile
bioactive
molecules
on
several
parameters,
such
as
saliva
serum
biomarkers,
explored
gut
oral
microbiota
regarding
Bacillota
Bacteroidota
content.
Thus,
glycated
haemoglobin
(HbA1c),
low-density
lipoprotein
(LDL-C),
C-reactive
protein
(CRP),
faecal
salivary
microbiomes
were
evaluated
before
after
exposure
EVOO.
The
results
showed
promotes
decrease
HbA1C
pro-inflammatory
interleukin
IL-1β,
associated
processes.
Moreover,
intake
modulated
microbiota,
increasing
both
ecological
niches
phyla
being
health,
demonstrating
prebiotic
effect.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(3), P. e0320383 - e0320383
Published: March 25, 2025
Objectives
The
oral–gut
axis
is
believed
to
play
a
role
in
the
pathogenesis
of
colorectal
cancer
(CRC).
Previous
studies
have
demonstrated
transmission
oral
microbiota
gut,
disrupting
gut
microbial
balance
and
creating
protumorigenic
microenvironment
conducive
CRC
progression.
Fusobacterium
nucleatum
putative
periodontal
pathogen
recognized
as
specific
bacterium
that
promotes
development.
However,
possible
involvement
other
pathogens
poorly
understood.
This
study
aimed
explore
effects
ingested
on
experimental
mice
elucidate
underlying
mechanisms.
Methods
In
this
study,
colitis-induced
mouse
models
were
used.
orally
administered
(
Porphyromonas
gingivalis
Prevotella
intermedia
)
three
times
week
during
period.
severity
between
P.
-treated
groups
was
compared.
Lumen-associated
(LAM)
mucosa-associated
(MAM)
analyzed
both
human
samples.
vitro
conducted
using
intestinal
epithelial
cells
mechanisms
by
which
affect
Results
group
exhibited
significantly
increased
compared
among
azoxymethane/dextran
sodium
sulfate
(AOM/DSS)-induced
models.
LAM
MAM
distinct
bacterial
compositions,
enriched
more
than
LAM.
adhesion
assays
revealed
had
higher
adhesive
capacity
indicated
gingipains
such
capacity.
Conclusion
MAM,
its
subsequent
potentially
involved
progression
CRC.
