Journal of Hospital Infection, Journal Year: 2024, Volume and Issue: 149, P. 46 - 55
Published: May 11, 2024
Invasive fungal infections pose a substantial threat to patients in healthcare settings globally. Recent changes the prevalence of species and challenges conducting reference antifungal susceptibility testing emphasize importance monitoring fungi their resistance.
Language: Английский
Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 423 - 439
Published: Jan. 1, 2025
Antimicrobial resistance (AMR) is a major threat to global public health. The current review synthesizes address the possible role of Artificial Intelligence and Machine Learning (AI/ML) in mitigating AMR. Supervised learning, unsupervised deep reinforcement natural language processing are some main tools used this domain. AI/ML models can use various data sources, such as clinical information, genomic sequences, microbiome insights, epidemiological for predicting AMR outbreaks. Although relatively new fields, numerous case studies offer substantial evidence their successful application outbreaks with greater accuracy. These provide insights into discovery novel antimicrobials, repurposing existing drugs, combination therapy through analysis molecular structures. In addition, AI-based decision support systems real-time guide healthcare professionals improve prescribing antibiotics. also outlines how AI surveillance, analyze trends, enable early outbreak identification. Challenges, ethical considerations, privacy, model biases exist, however, continuous development methodologies enables play significant combating
Language: Английский
Citations
7
Antibiotics, Journal Year: 2023, Volume and Issue: 12(3), P. 608 - 608
Published: March 18, 2023
Fungal infections are becoming one of the main causes morbidity and mortality in people with weakened immune systems. Mycoses more common, despite greater knowledge better treatment methods, due to regular emergence resistance antifungal medications used clinical settings. Antifungal therapy is mainstay patient management for acute chronic mycoses. However, limited availability drug classes limits range available treatments. Additionally, several drawbacks treating mycoses include unfavourable side effects, a activity spectrum, paucity targets, fungal resistance, all which continue be significant issues developing drugs. The has eliminated accessible as choices, significantly compromises illnesses. In some situations, strains resistant many major concern. Although new have been developed address this issue, grown pronounced, particularly patients who need long-term care or undergoing prophylaxis. Moreover, mechanisms that cause must well understood, including modifications target affinities abundances, along biofilms efflux pumps diminish intracellular levels, find novel drugs targets. review, different agents, their mechanisms, discussed. latter part review focuses on strategies by we can overcome serious issue humans.
Language: Английский
Citations
30
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 28, 2025
Candidiasis poses a significant threat to human health, especially in immunocompromised patients. However, there is paucity of epidemiological data concerning the prevalence candidiasis developing regions China. We conducted retrospective study on patients positive for Candida infections tertiary care hospital Shantou, China, identify clinical characteristics and risk factors candidiasis. Of 5,095 cases candidiasis, 489 (9.59%) were candidemia infections. albicans (n = 230, 47.0%) was predominant species identified among all Non-albicans (NAC) more prevalent adult patients, while glabrata slightly frequent pediatric 10, 14.7%). Pulmonary diseases 200, 47.8%) most common underlying comorbidities 25, 35.2%). Thrombocytopenia only laboratory finding higher than Respiratory dysfunction, presence central venous catheter, septic shock, thrombocytopenia independent candidemia-related 30-day mortality. Amphotericin B exhibited high efficacy (100%), itraconazole lowest against tested isolates. C. had lower susceptibility azole, although this not statistically significant. The specifically varied regarding associated factors. This provides guidance prescribing appropriate therapy yields insights into patterns different isolates antifungal drugs.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 28, 2024
Interleukins (ILs) are vital in regulating the immune system, enabling to combat fungal diseases like candidiasis effectively. Their inhibition may cause enhanced susceptibility infection. IL inhibitors have been employed control autoimmune and of IL-17 IL-23, for example, associated with an elevated risk
Language: Английский
Citations
6
The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
5
Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155948 - 155948
Published: Aug. 10, 2024
Language: Английский
Citations
4
New Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Nature and Science of Medicine, Journal Year: 2025, Volume and Issue: 8(1), P. 98 - 106
Published: Jan. 1, 2025
Abstract Context: Candida species are common pathogens causing a range of infections from mucocutaneous to systemic. The increasing antifungal resistance among presents substantial challenge in healthcare settings. Aims: This study examines the distribution and susceptibility patterns provide insights into regional epidemiology resistance. Settings Design: A retrospective, observational, single-center was conducted analyze various clinical samples their at Justice K. S. Hegde Charitable Hospital, 1000-bed tertiary teaching hospital Mangalore. Subjects Methods: identification performed using automated systems, while testing done VITEK 2 AST YS08 system. Relevant information electronic medical records all positively identified cases reviewed recorded. Statistical Analysis Used: Package for Social Sciences (SPSS) software version 20 used evaluate, code, verify, statistically acquired data. Results: In total, 701 isolates were identified, with C. albicans being most (290, 41.4%). Among non-albicans Candida, tropicalis (209, 29.8%) predominant, followed by parapsilosis (91, 13%), glabrata (32, 4.6%) krusei 4.6%). Resistance showed auris had highest fluconazole voriconazole. Sensitivity micafungin caspofungin. Most patients type diabetes or hypertension as comorbidities. Conclusions: varied species, revealing differences international studies. results underscore importance ongoing local surveillance epidemiological studies monitor Understanding mechanisms is essential effective treatment strategies controlling invasive infections. Enhanced data can help optimizing therapies preventing
Language: Английский
Citations
0
Journal of Yeast and Fungal Research, Journal Year: 2025, Volume and Issue: 16(1), P. 1 - 8
Published: Jan. 31, 2025
Language: Английский
Citations
0
Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: March 22, 2025
Aims Candidiasis, caused by Candida spp. is an opportunistic infection with significant healthcare risks, worsened trends in antifungal resistance. This study aimed to evaluate the susceptibility profile, investigate resistance mechanisms, assess efflux pump activity, and examine biocide tolerance clinical isolates.
Language: Английский
Citations
0