Journal of Hospital Infection,
Journal Year:
2024,
Volume and Issue:
149, P. 46 - 55
Published: May 11, 2024
Invasive
fungal
infections
pose
a
substantial
threat
to
patients
in
healthcare
settings
globally.
Recent
changes
the
prevalence
of
species
and
challenges
conducting
reference
antifungal
susceptibility
testing
emphasize
importance
monitoring
fungi
their
resistance.
Computational and Structural Biotechnology Journal,
Journal Year:
2025,
Volume and Issue:
27, P. 423 - 439
Published: Jan. 1, 2025
Antimicrobial
resistance
(AMR)
is
a
major
threat
to
global
public
health.
The
current
review
synthesizes
address
the
possible
role
of
Artificial
Intelligence
and
Machine
Learning
(AI/ML)
in
mitigating
AMR.
Supervised
learning,
unsupervised
deep
reinforcement
natural
language
processing
are
some
main
tools
used
this
domain.
AI/ML
models
can
use
various
data
sources,
such
as
clinical
information,
genomic
sequences,
microbiome
insights,
epidemiological
for
predicting
AMR
outbreaks.
Although
relatively
new
fields,
numerous
case
studies
offer
substantial
evidence
their
successful
application
outbreaks
with
greater
accuracy.
These
provide
insights
into
discovery
novel
antimicrobials,
repurposing
existing
drugs,
combination
therapy
through
analysis
molecular
structures.
In
addition,
AI-based
decision
support
systems
real-time
guide
healthcare
professionals
improve
prescribing
antibiotics.
also
outlines
how
AI
surveillance,
analyze
trends,
enable
early
outbreak
identification.
Challenges,
ethical
considerations,
privacy,
model
biases
exist,
however,
continuous
development
methodologies
enables
play
significant
combating
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(3), P. 608 - 608
Published: March 18, 2023
Fungal
infections
are
becoming
one
of
the
main
causes
morbidity
and
mortality
in
people
with
weakened
immune
systems.
Mycoses
more
common,
despite
greater
knowledge
better
treatment
methods,
due
to
regular
emergence
resistance
antifungal
medications
used
clinical
settings.
Antifungal
therapy
is
mainstay
patient
management
for
acute
chronic
mycoses.
However,
limited
availability
drug
classes
limits
range
available
treatments.
Additionally,
several
drawbacks
treating
mycoses
include
unfavourable
side
effects,
a
activity
spectrum,
paucity
targets,
fungal
resistance,
all
which
continue
be
significant
issues
developing
drugs.
The
has
eliminated
accessible
as
choices,
significantly
compromises
illnesses.
In
some
situations,
strains
resistant
many
major
concern.
Although
new
have
been
developed
address
this
issue,
grown
pronounced,
particularly
patients
who
need
long-term
care
or
undergoing
prophylaxis.
Moreover,
mechanisms
that
cause
must
well
understood,
including
modifications
target
affinities
abundances,
along
biofilms
efflux
pumps
diminish
intracellular
levels,
find
novel
drugs
targets.
review,
different
agents,
their
mechanisms,
discussed.
latter
part
review
focuses
on
strategies
by
we
can
overcome
serious
issue
humans.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 28, 2025
Candidiasis
poses
a
significant
threat
to
human
health,
especially
in
immunocompromised
patients.
However,
there
is
paucity
of
epidemiological
data
concerning
the
prevalence
candidiasis
developing
regions
China.
We
conducted
retrospective
study
on
patients
positive
for
Candida
infections
tertiary
care
hospital
Shantou,
China,
identify
clinical
characteristics
and
risk
factors
candidiasis.
Of
5,095
cases
candidiasis,
489
(9.59%)
were
candidemia
infections.
albicans
(n
=
230,
47.0%)
was
predominant
species
identified
among
all
Non-albicans
(NAC)
more
prevalent
adult
patients,
while
glabrata
slightly
frequent
pediatric
10,
14.7%).
Pulmonary
diseases
200,
47.8%)
most
common
underlying
comorbidities
25,
35.2%).
Thrombocytopenia
only
laboratory
finding
higher
than
Respiratory
dysfunction,
presence
central
venous
catheter,
septic
shock,
thrombocytopenia
independent
candidemia-related
30-day
mortality.
Amphotericin
B
exhibited
high
efficacy
(100%),
itraconazole
lowest
against
tested
isolates.
C.
had
lower
susceptibility
azole,
although
this
not
statistically
significant.
The
specifically
varied
regarding
associated
factors.
This
provides
guidance
prescribing
appropriate
therapy
yields
insights
into
patterns
different
isolates
antifungal
drugs.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 28, 2024
Interleukins
(ILs)
are
vital
in
regulating
the
immune
system,
enabling
to
combat
fungal
diseases
like
candidiasis
effectively.
Their
inhibition
may
cause
enhanced
susceptibility
infection.
IL
inhibitors
have
been
employed
control
autoimmune
and
of
IL-17
IL-23,
for
example,
associated
with
an
elevated
risk
Journal of Nature and Science of Medicine,
Journal Year:
2025,
Volume and Issue:
8(1), P. 98 - 106
Published: Jan. 1, 2025
Abstract
Context:
Candida
species
are
common
pathogens
causing
a
range
of
infections
from
mucocutaneous
to
systemic.
The
increasing
antifungal
resistance
among
presents
substantial
challenge
in
healthcare
settings.
Aims:
This
study
examines
the
distribution
and
susceptibility
patterns
provide
insights
into
regional
epidemiology
resistance.
Settings
Design:
A
retrospective,
observational,
single-center
was
conducted
analyze
various
clinical
samples
their
at
Justice
K.
S.
Hegde
Charitable
Hospital,
1000-bed
tertiary
teaching
hospital
Mangalore.
Subjects
Methods:
identification
performed
using
automated
systems,
while
testing
done
VITEK
2
AST
YS08
system.
Relevant
information
electronic
medical
records
all
positively
identified
cases
reviewed
recorded.
Statistical
Analysis
Used:
Package
for
Social
Sciences
(SPSS)
software
version
20
used
evaluate,
code,
verify,
statistically
acquired
data.
Results:
In
total,
701
isolates
were
identified,
with
C.
albicans
being
most
(290,
41.4%).
Among
non-albicans
Candida,
tropicalis
(209,
29.8%)
predominant,
followed
by
parapsilosis
(91,
13%),
glabrata
(32,
4.6%)
krusei
4.6%).
Resistance
showed
auris
had
highest
fluconazole
voriconazole.
Sensitivity
micafungin
caspofungin.
Most
patients
type
diabetes
or
hypertension
as
comorbidities.
Conclusions:
varied
species,
revealing
differences
international
studies.
results
underscore
importance
ongoing
local
surveillance
epidemiological
studies
monitor
Understanding
mechanisms
is
essential
effective
treatment
strategies
controlling
invasive
infections.
Enhanced
data
can
help
optimizing
therapies
preventing
Future Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: March 22, 2025
Aims
Candidiasis,
caused
by
Candida
spp.
is
an
opportunistic
infection
with
significant
healthcare
risks,
worsened
trends
in
antifungal
resistance.
This
study
aimed
to
evaluate
the
susceptibility
profile,
investigate
resistance
mechanisms,
assess
efflux
pump
activity,
and
examine
biocide
tolerance
clinical
isolates.