Emerging trends of invasive yeast infections and azole resistance in Beijing intensive care units DOI Creative Commons
J. Yu, Wenjie Yang, Xing Fan

et al.

Journal of Hospital Infection, Journal Year: 2024, Volume and Issue: 149, P. 46 - 55

Published: May 11, 2024

Invasive fungal infections pose a substantial threat to patients in healthcare settings globally. Recent changes the prevalence of species and challenges conducting reference antifungal susceptibility testing emphasize importance monitoring fungi their resistance.

Language: Английский

The Role of Artificial Intelligence and Machine Learning in Predicting and Combating Antimicrobial Resistance DOI Creative Commons
Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 423 - 439

Published: Jan. 1, 2025

Antimicrobial resistance (AMR) is a major threat to global public health. The current review synthesizes address the possible role of Artificial Intelligence and Machine Learning (AI/ML) in mitigating AMR. Supervised learning, unsupervised deep reinforcement natural language processing are some main tools used this domain. AI/ML models can use various data sources, such as clinical information, genomic sequences, microbiome insights, epidemiological for predicting AMR outbreaks. Although relatively new fields, numerous case studies offer substantial evidence their successful application outbreaks with greater accuracy. These provide insights into discovery novel antimicrobials, repurposing existing drugs, combination therapy through analysis molecular structures. In addition, AI-based decision support systems real-time guide healthcare professionals improve prescribing antibiotics. also outlines how AI surveillance, analyze trends, enable early outbreak identification. Challenges, ethical considerations, privacy, model biases exist, however, continuous development methodologies enables play significant combating

Language: Английский

Citations

7

Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review DOI Creative Commons
Ali A. Rabaan, Tarek Sulaiman,

Shamsah H. Al-Ahmed

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(3), P. 608 - 608

Published: March 18, 2023

Fungal infections are becoming one of the main causes morbidity and mortality in people with weakened immune systems. Mycoses more common, despite greater knowledge better treatment methods, due to regular emergence resistance antifungal medications used clinical settings. Antifungal therapy is mainstay patient management for acute chronic mycoses. However, limited availability drug classes limits range available treatments. Additionally, several drawbacks treating mycoses include unfavourable side effects, a activity spectrum, paucity targets, fungal resistance, all which continue be significant issues developing drugs. The has eliminated accessible as choices, significantly compromises illnesses. In some situations, strains resistant many major concern. Although new have been developed address this issue, grown pronounced, particularly patients who need long-term care or undergoing prophylaxis. Moreover, mechanisms that cause must well understood, including modifications target affinities abundances, along biofilms efflux pumps diminish intracellular levels, find novel drugs targets. review, different agents, their mechanisms, discussed. latter part review focuses on strategies by we can overcome serious issue humans.

Language: Английский

Citations

30

An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China DOI Creative Commons
Sabir Khan, Lin Cai, Hazrat Bilal

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 28, 2025

Candidiasis poses a significant threat to human health, especially in immunocompromised patients. However, there is paucity of epidemiological data concerning the prevalence candidiasis developing regions China. We conducted retrospective study on patients positive for Candida infections tertiary care hospital Shantou, China, identify clinical characteristics and risk factors candidiasis. Of 5,095 cases candidiasis, 489 (9.59%) were candidemia infections. albicans (n = 230, 47.0%) was predominant species identified among all Non-albicans (NAC) more prevalent adult patients, while glabrata slightly frequent pediatric 10, 14.7%). Pulmonary diseases 200, 47.8%) most common underlying comorbidities 25, 35.2%). Thrombocytopenia only laboratory finding higher than Respiratory dysfunction, presence central venous catheter, septic shock, thrombocytopenia independent candidemia-related 30-day mortality. Amphotericin B exhibited high efficacy (100%), itraconazole lowest against tested isolates. C. had lower susceptibility azole, although this not statistically significant. The specifically varied regarding associated factors. This provides guidance prescribing appropriate therapy yields insights into patterns different isolates antifungal drugs.

Language: Английский

Citations

2

Interleukin inhibitors and the associated risk of candidiasis DOI Creative Commons
Sabir Khan, Hazrat Bilal, Muhammad Nadeem Khan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 28, 2024

Interleukins (ILs) are vital in regulating the immune system, enabling to combat fungal diseases like candidiasis effectively. Their inhibition may cause enhanced susceptibility infection. IL inhibitors have been employed control autoimmune and of IL-17 IL-23, for example, associated with an elevated risk

Language: Английский

Citations

6

Antifungal susceptibility testing: applicability of methods and strategies for improving access in resource-constrained settings DOI
Richard Kwizera, Alireza Abdolrasouli, Guillermo García‐Effrón

et al.

The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

5

Discovery of petroselinic acid with in vitro and in vivo antifungal activity by targeting fructose-1,6-bisphosphate aldolase DOI
Xinrong Wang, Hua Zhong,

Ma Shanshan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155948 - 155948

Published: Aug. 10, 2024

Language: Английский

Citations

4

Screening a 681-membered yeast collection for the secretion of proteins with antifungal activity DOI Creative Commons
Alicia Maciá Valero,

Fatemehalsadat Tabatabaeifar,

Sonja Billerbeck

et al.

New Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Frequency and Antifungal Susceptibility Patterns of Candida Species Isolated from Clinical Samples of Patients Attending to a Tertiary Healthcare Setting in Karnataka, India DOI Creative Commons
Asem Ali Ashraf, Vimal Kumar Karnaker,

Ganesh Ramanath

et al.

Journal of Nature and Science of Medicine, Journal Year: 2025, Volume and Issue: 8(1), P. 98 - 106

Published: Jan. 1, 2025

Abstract Context: Candida species are common pathogens causing a range of infections from mucocutaneous to systemic. The increasing antifungal resistance among presents substantial challenge in healthcare settings. Aims: This study examines the distribution and susceptibility patterns provide insights into regional epidemiology resistance. Settings Design: A retrospective, observational, single-center was conducted analyze various clinical samples their at Justice K. S. Hegde Charitable Hospital, 1000-bed tertiary teaching hospital Mangalore. Subjects Methods: identification performed using automated systems, while testing done VITEK 2 AST YS08 system. Relevant information electronic medical records all positively identified cases reviewed recorded. Statistical Analysis Used: Package for Social Sciences (SPSS) software version 20 used evaluate, code, verify, statistically acquired data. Results: In total, 701 isolates were identified, with C. albicans being most (290, 41.4%). Among non-albicans Candida, tropicalis (209, 29.8%) predominant, followed by parapsilosis (91, 13%), glabrata (32, 4.6%) krusei 4.6%). Resistance showed auris had highest fluconazole voriconazole. Sensitivity micafungin caspofungin. Most patients type diabetes or hypertension as comorbidities. Conclusions: varied species, revealing differences international studies. results underscore importance ongoing local surveillance epidemiological studies monitor Understanding mechanisms is essential effective treatment strategies controlling invasive infections. Enhanced data can help optimizing therapies preventing

Language: Английский

Citations

0

Epidemiological and antifungal susceptibility profile of the causative fungal agents of otomycosis in patients diagnosed at the University Hospital of Angr, Abidjan (Cte dIvoire) DOI Open Access

Etienne Angora Kpongbo,

Assouhoun Jean Miezan Sébastien,

Aline N’guiachi Maurine

et al.

Journal of Yeast and Fungal Research, Journal Year: 2025, Volume and Issue: 16(1), P. 1 - 8

Published: Jan. 31, 2025

Language: Английский

Citations

0

Unveiling antifungal resistance and biocide tolerance in clinical isolates of Candida spp DOI
Jamile de Paiva Macedo,

Aripuanã Sakurada Aranha Watanabe,

Alessandra Barbosa Ferreira Machado

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: March 22, 2025

Aims Candidiasis, caused by Candida spp. is an opportunistic infection with significant healthcare risks, worsened trends in antifungal resistance. This study aimed to evaluate the susceptibility profile, investigate resistance mechanisms, assess efflux pump activity, and examine biocide tolerance clinical isolates.

Language: Английский

Citations

0